A5045147408- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Gestational Trophoblastic Disease Studies
- Urinary and Genital Oncology Studies
- Cancer Risks and Factors
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Gestational Diabetes Research and Management
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Neuroendocrine Tumor Research Advances
- Pregnancy and preeclampsia studies
- Gastric Cancer Management and Outcomes
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related molecular mechanisms research
- Ectopic Pregnancy Diagnosis and Management
- Circular RNAs in diseases
- Cancer Research and Treatments
- Breast Cancer Treatment Studies
- Urologic and reproductive health conditions
Kyushu University
2010-2020
Kyushu University Hospital
2007-2019
Beijing Obstetrics and Gynecology Hospital
2006-2017
Oita Prefectural Hospital
2014
Japanese Red Cross Fukuoka Hospital
2014
National Hospital Organization Kyushu Cancer Center
2004
Differential methylation between the two alleles of a gene has been observed in imprinted regions, where one allele occurs on parent-of-origin basis, inactive X-chromosome females, and at those loci whose is driven by genetic variants. We have extensively characterized substantial range normal human tissues, reciprocal genome-wide uniparental disomies, hydatidiform moles, using combination whole-genome bisulfite sequencing high-density microarrays. This approach allowed us to define profiles...
Classification and terminology of non–low-grade endometrial sarcomas, which show significant nuclear atypia, have been controversial. Currently, these tumors seem to be classified all together into "undifferentiated sarcoma (UES)." However, it remains unclear whether sarcomas are universally "undifferentiated." We divided morphologically undifferentiated with uniformity (UES-U) pleomorphism (UES-P), compared their molecular genetic immunohistochemical profiles. Eighteen low-grade stromal...
Gastric-type mucinous carcinoma (GAS) is a novel variant of the uterine cervix. As shown in original Japanese group description, recent studies, GAS represents more aggressive disease than usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features this remain to be elucidated larger series patients.Patients were enrolled by Gynecologic Cancer Study Group Japan Clinical Oncology after receiving approval each Institutional Review Board. The study population comprised...
Aims: Squamous cell carcinoma (SCC) is the most common form of malignant transformation in mature cystic teratoma (MCT) ovary. Some investigators have suggested possibility origin from columnar epithelium. The aim this study was to analyse such tumours immunohistochemically elucidate their histogenesis. Methods and results: expression cytokeratin (CK) 10 CK18 examined 21 samples SCC arising MCT. CK10 also assessed SCCs different organs (skin, vulva, lung uterine cervix) for purpose...
<b><i>Background and Objectives:</i></b> Trachelectomy, a fertility-sparing surgery for early-stage cervical cancer, can be performed only when there is no extrauterine extension present. Therefore, identifying the sentinel lymph nodes (SLNs) using them to obtain an intraoperative pathologic diagnosis provide information on feasibility safety of trachelectomy. Our aim was assess value SLN diagnosis. <b><i>Methods:</i></b> We retrospectively...
In the present study, we evaluated incidence of postmolar gestational trophoblastic disease (GTD) in molar pregnancy. We also validated macroscopic diagnosis based on Japan Society Obstetrics and Gynecology (JSOG) classification. A total 297 samples hydropic villi were classified according to DNA polymorphisms as androgenetic moles, dispermic triploids, or biparental diploids (hydropic abortion), clinically corresponding complete hydatidiform mole (CHM), partial (PHM), abortion,...
Abnormal activation and/or dysfunction of the maternal vascular endothelium have been implicated as a cause placental ischemia and oxidative damage associated with pregnancy-induced hypertension (PIH).To clarify relationship between systemic stress induced by reactive oxygen species (ROS), we immunostained placentas from 27 PIH pregnancies 41 normal for 8-hydroxy-2-deoxyguanosine (8OHdG).Positive 8OHdG staining was significantly more frequent in syncytiotrophoblasts compared to matched...
<b><i>Aim:</i></b> This study aimed to clarify the genetic and epigenetic features of recurrent hydatidiform mole (RHM) in Japanese patients. <b><i>Methods:</i></b> Four isolated RHM cases were analyzed using whole-exome sequencing. Villi from RHMs collected by laser microdissection for genotyping DNA methylation assay differentially methylated regions (DMRs). Single nucleotide polymorphisms <i>PEG3</i> <i>H19</i> DMRs...
The objective of our study was to determine the usefulness recognizing continuity gonadal veins pelvic mass differentiate ovarian versus uterine origin on MDCT in females with a large mass.Two radiologists interpreted images obtained monitor, using paging methods, 86 female patients (> 8 cm) and 40 without an abdominopelvic as control subjects. following issues were recorded 5-point scale: visualization determination based anatomic continuity. Receiver operating characteristic (ROC) curve...
Objective: For oncologic safety, vaginal radical trachelectomy is generally performed only in patients with cervical cancers smaller than 2 cm.However, because inclusion criteria for abdominal are controversial, we evaluated the safety of ≥2 cm.Methods: We began performing trachelectomies at our institution 2005, primarily squamous cell carcinoma ≤3 cm or adenocarcinoma/adenosquamous ≤2 cm.If a positive sentinel lymph node margin was diagnosed intraoperatively by frozen section, converted to...
Gα13, a heterotrimeric G-protein of the Gα12/13 subfamily, is associated with aggressive phenotypes in various human cancers. However, mechanisms by which Gα13 promotes cancer progression have not been fully elucidated. Here, we demonstrate that activation induces epithelial-mesenchymal transition ovarian (OvCa) cells through down-regulation large tumor suppressor kinase (LATS) 1, critical component Hippo signaling pathway. A synthetic biology approach using mutant GPCR and chimeric revealed...
BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors involved in multiple cell activities including epithelial-to-mesenchymal transition (EMT). However, the expression mechanism of BHLHE40/41 EMT remains unclear. In present study, we showed that levels were negatively correlated with those microRNA (MIR) 130 family endometrial cancer (EC) specimens. Our vitro assays indicated was suppressed directly by MIR130 a 3'-untranslated region-mediated manner. EC...
The rare phenomenon of tumor-to-tumor metastasis was first described in 1930. donor neoplasm is most frequently lung or breast carcinoma, whereas intracranial meningiomas are reportedly the commonest recipient neoplasm. Here we report a case from primary gastric cancer to uterine lipoleiomyoma. A 65-year-old woman presented with locally advanced computed tomography (CT) evidence peritoneal dissemination and 9 cm pelvic mass. She underwent 16 courses TS-1/cisplatin chemotherapy, which...
<b><i>Introduction:</i></b> Adjuvant therapy is usually recommended for patients with intermediate-risk cervical cancer (deep stromal invasion [DSI], lymphovascular space [LVSI], and bulky tumor) after radical hysterectomy. However, we previously reported that DSI, LVSI, squamous cell carcinoma (SCC) were not correlated prognosis in multivariate analysis; therefore, the indications use adjuvant include complete invasion, DSI or LVSI SCC. The objective of this study...
Abstract Aim Only a few reports of pelvic abscess as late complication trachelectomy have been published to date. To evaluate the cases abdominal for cervical cancer. Methods In June 2005, we began clinical trial at our institution. Written informed consent was obtained from all patients. We retrospectively reviewed medical records patients who underwent and extracted data experienced complication. Results From 2005 September 2017, performed 181 trachelectomies total, 15 abscesses occurred...
•This report shows very rare cases of small cell carcinoma the ovary, hypercalcemic type and pulmonary type.•Their chemo sensitivity is quite different. These two followed opposite clinical courses.•The first case (SCOHT) progressed rapidly, showed resistance to chemotherapy radiotherapy.•The second (SCOPT) radiotherapy although recurrence was repeated.
Abstract Metastasis to the mandibular condyle is rare, and such lesions should be identified by both clinical pathological examinations. We experienced a case of adenocarcinoma occurring in right condyle. A 65‐year‐old female with uterine cervical cancer showed condylar dysfunction. Imaging examinations revealed tumor bone destruction rapidly progressive course, while suggested metastasis originating from another site. Based on findings, patient was diagnosed derived cervix, addition...
Müllerian mucinous borderline tumors (MMBTs) usually arise from the ovary. The present report is first case of primary uterine MMBTs associated with adenomyosis. A 51-year-old woman was referred to our hospital for a complex cystic and solid 4×3 cm right adnexal mass. She had history left ovarian endometriotic cyst undergone oophorectomy 2 yr prior. laparotomy performed, tumor found be originating in posterior wall uterus. underwent total abdominal hysterectomy, salpingo-oophorectomy,...