A5060966550- Tea Polyphenols and Effects
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Fermentation and Sensory Analysis
- Genomics, phytochemicals, and oxidative stress
- Pharmacogenetics and Drug Metabolism
- Polysaccharides and Plant Cell Walls
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Inflammatory Biomarkers in Disease Prognosis
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Pharmacological Effects of Natural Compounds
- Biosensors and Analytical Detection
- Metabolism, Diabetes, and Cancer
- Mass Spectrometry Techniques and Applications
- Ginseng Biological Effects and Applications
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Ginger and Zingiberaceae research
- Helicobacter pylori-related gastroenterology studies
- Arsenic contamination and mitigation
- GDF15 and Related Biomarkers
- Tannin, Tannase and Anticancer Activities
- Metabolomics and Mass Spectrometry Studies
Guangdong Academy of Agricultural Sciences
2020-2025
Tea Research Institute
2020-2025
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2016-2025
Sun Yat-sen University
2012-2024
Zhejiang University
2022-2023
Beijing Foreign Studies University
2006-2023
Wuhan University
2023
Ministry of Agriculture and Rural Affairs
2018-2020
South China Agricultural University
2016-2020
The digestion and absorption characteristics of mulberry leaf polyphenols (MLPP), polysaccharides (MLPS), polyphenol-polysaccharide complex (PPPS) were compared the changes in short chain fatty acids (SCFAs) analyzed during fermentation process. impact PPPS on structural composition intestinal microbiota was investigated based 16S rDNA gene sequencing. digestibility rates MLPP 59.48% 79.95%, respectively, while no free monosaccharide detected MLPS PPPS, indicating that promoted existence had...
The relationship between 25-hydroxyvitamin D (25(OH)D) status and cardiovascular disease (CVD) in the diabetes population still needs to be clarified. This study aimed explore association of 25(OH)D with CVD cardiometabolic risk factors Chinese type 2 mellitus (T2DM). cross-sectional was performed 1378 hospitalized patients T2DM. Participants were classified into three groups according serum levels: vitamin adequate, insufficiency deficient. Multivariate logistic regression analysis,...
The health benefits of tea are as diverse including the reduction uric acid levels. Xanthine oxidase is most directly mediated enzyme in production acid.To explore inhibitory effects different teas and its main bioactive components on acid.Experimental study. experiments were conducted vitro using human immortalized normal liver cell line HL-7702 (L-02).The inhibition xanthine activities expression level dehydrogenase mRNA stimulated hyperuric hepatocyte model showed that unfermented green...
Abstract Interleukin-33 (IL-33), an emerging cytokine within the IL-1 family, assumes a pivotal function in control of obesity. However, specific mechanism its regulation obesity formation remains unclear. In this study, we found that expression level IL-33 increased visceral adipose tissue mice fed with high-fat diet (HFD) compared normal (ND). vitro, also was upregulated during adipogenesis 3T3-L1 cells. Functional test results showed knockdown cells differentiation could promote...
The sensory quality of black tea (BT) influenced by various factors, among which tree age is particularly significant. People prefer BT produced fresh leaves from old trees, yet the correlation between and has not been thoroughly investigated. In this study, we analyzed young trees (H-JYH) (H-OJYH) using e-tongue technology evaluation. Our findings revealed that H-OJYH had stronger sweetness sourness, richer flavor, diminished bitter-astringency compared to H-JYH. 1231 non-volatile...
Cytochrome P450 1A1 (CYP1A1) is abundant in the kidney, liver, and intestine involved phase I metabolism of numerous endogenous exogenous compounds. Therefore, exploring regulatory mechanism its basal expression humans particularly important to understand bioactivation several procarcinogens their carcinogenic derivatives. Site‐specific mutagenesis deletion transcription factor binding site determined core cis ‐acting elements human CYP1A1 proximal distal promoter regions. The region...
Diabetic nephropathy (DN) is the most important cause of middle and late-stage chronic kidney disease. Green tea polypeptides are extracted from pomace, exhibit various pharmacological effects. In this study, we analyzed reno-protective effects green peptides in diabetic db/db mice, explored underlying mechanisms. Peptide treatment for 5 weeks significantly reduced blood glucose levels other indices diabetes, alleviated renal injury measured terms creatinine, urea nitrogen urinary...
Hyperuricemia (HUA) is a metabolic disease that threatens human health. Tea healthy beverage with an abundance of benefits. This study revealed the uric acid-lowering efficacy six types tea water extracts (TWEs) on HUA in mice. The results under intervention TWEs, expression XDH, key enzyme produces acid, was significantly downregulated liver. TWE treatment upregulated acid secretion transporters ABCG2, OAT1, and OAT3, reabsorption transporter URAT1 kidney. Furthermore, HUA-induced oxidative...
The gut-liver axis is a bidirectional relationship between the gut with its microbiota and hepatic. Ulcerative colitis (UC) disrupts intestinal barrier influx of microorganisms their products into liver, which trigger liver injury. Tea consumption associated low incidence UC in Asian countries. In this study, we revealed mechanisms six types tea water extracts (TWEs) obtained from leaves Camellia sinensis on dextran sodium sulfate (DSS)-induced injury mice. TWEs significantly restored mucin...
Tea is the most popular and widely consumed beverage worldwide, especially black tea. Summer tea has a bitter astringent taste low aroma compared to spring due higher content of polyphenols lower amino acids. Microbial fermentation routinely used improve flavor various foods. This study analyzed relationship between quality tea, metabolic characteristics, microbial communities after stuck in summer Stuck decreased bitterness, astringency sourness, freshness, increased sweetness, mellowness,...