A5046428337- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Advanced Drug Delivery Systems
- Free Radicals and Antioxidants
- Advancements in Transdermal Drug Delivery
- Phytochemicals and Antioxidant Activities
- Pesticide and Herbicide Environmental Studies
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Renal function and acid-base balance
- Biosensors and Analytical Detection
- Antioxidant Activity and Oxidative Stress
- Spectroscopy and Chemometric Analyses
- HIV/AIDS Research and Interventions
- Electrochemical Analysis and Applications
- Dye analysis and toxicity
- Mass Spectrometry Techniques and Applications
- Tea Polyphenols and Effects
- Papaya Research and Applications
- Drug Solubulity and Delivery Systems
- Pharmacological Effects and Assays
- Forensic Toxicology and Drug Analysis
- Microbial bioremediation and biosurfactants
- Advanced Photocatalysis Techniques
- Microbial Community Ecology and Physiology
Universidade do Porto
2016-2025
Rede de Química e Tecnologia
2016-2025
Polytechnic Institute of Porto
2015-2025
Universidade Católica Portuguesa
2003-2012
Universidade Federal do Paraná
1999
Around two million tons of olive oil are produced in Europe annually, with Portugal being among the top five European oil-producing countries. Olive production results a substantial amount waste form leaves. These discarded leaves contain valuable phenolic compounds antioxidant, anti-inflammatory, hypoglycaemic, neuroprotective, and antiproliferative properties. Due to their richness polyphenols health-promoting properties, can be considered potential functional food ingredient. Thus,...
The analysis and interpretation of data retrieved from Oxygen Radical Absorbance Capacity (ORAC) assays represent a challenging task. ORAC indexes originate different mathematical approaches often lacking correct elucidation kinetic features concerning radical scavenging reactions by antioxidant compounds. In this work, the expression values as area under fluorescein (FL) decay curves (AUC) lag time are critically compared. This multi-parametric showed extension beyond period for caffeic...
Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and well-established risk factor for the development of cardiovascular (CVD). Gut dysbiosis may contribute to CVD inflammation CKD patients. Nonetheless, role gut blood microbiomes CKD-associated VC remains unknown. Therefore, this pilot study aimed explore link between patients on peritoneal dialysis (CKD-PD). Our results showed relative changes specific taxa CKD-PD with without VC, namely Coprobacter,...
Green and environmentally friendly approaches are increasingly necessary when developing new analytical methodologies. Electromembrane extraction (EME) has contributed to this by offering alternatives the traditional widely used plastic materials. Specially, those derived from biopolymers (such as agarose or chitosan) have recently gained a great importance in EME they biodegradable sustainable, which constitutes major advantage environmental impact of these processes. This review is...
Summary A bacterial mixed culture able to mineralize molinate was established, through enrichment, using mineral medium with as the only carbon, nitrogen and energy source. The combination of five cultivable isolates, purified from enrichment culture, permitted reconstitution a degrading consortium. Both defined cultures were without accumulation degradation products by end growth. Among isolates constituting an actinomycete, strain ON4, essential for biodegradation, being involved in...
Antiretroviral drug nanocarriers hold great promise for developing anti-human immunodeficiency virus (HIV) rectal microbicides. However, challenges remain, namely, concerning which properties are more suited enhancing colorectal distribution and retention of microbicide compounds. In this work, we developed assessed the in vitro vivo performance poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) as carriers model efavirenz (EFV). We particularly focused on effect noncovalent...
The evaluation of encapsulation efficiency is a regulatory requirement for the characterization drug delivery systems. However, difficulties in efficiently separating nanomedicines from free may compromise achievement accurate determinations. Herein, ultrafiltration was exploited as separative strategy towards methotrexate (MTX) nanostructured lipid carriers and polymeric nanoparticles. effect experimental conditions such pH amount surfactant present media addressed aiming at selection...
The presence of endocrine-disrupting compounds (EDCs) in water poses a significant threat to human and animal health, as recognized by regulatory agencies throughout the world. Yeast estrogen screen (YES) assay is an excellent method evaluate these due its simplicity capacity assess bio-accessible forms/fractions compounds. In compound with estrogenic activity, Saccharomyces cerevisiae cells, containing lacZ reporter gene encoding enzyme β-galactosidase, are induced, synthesised, released...
Beer is considered one of the most consumed beverages worldwide and a potential vehicle for probiotics. However, there are several technical challenges to overcome during production storage beers, as probiotics must remain viable until moment consumption. Therefore, this work aims discuss how incorporation improves or adds value beer which variables influence viability process. This narrative review literature with research in PubMed, Web Science, b-on databases articles related that The...
Background/Objectives: The leakage of 5-fluorouracil (5-FU) from elastomeric infusion pumps used in cancer therapy poses a potential risk unintentional exposure to multiple individuals, including patients’ relatives and healthcare professionals, may also compromise the accurate administration 5-FU dosages patients. This study aimed develop, validate, apply an analytical method detect quantify residues on external surfaces pumps. Methods: A high-performance liquid chromatography with...