A5011058680- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Phytochemicals and Antioxidant Activities
- Advanced Chemical Sensor Technologies
- Free Radicals and Antioxidants
- Electrochemical Analysis and Applications
- Biosensors and Analytical Detection
- Metabolomics and Mass Spectrometry Studies
- Electrochemical sensors and biosensors
- Pesticide Residue Analysis and Safety
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical Chemistry and Sensors
- Antioxidant Activity and Oxidative Stress
- Microfluidic and Capillary Electrophoresis Applications
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Fermentation and Sensory Analysis
- Dye analysis and toxicity
- Lipid Membrane Structure and Behavior
- Nitric Oxide and Endothelin Effects
- Water Quality Monitoring and Analysis
- Advanced Biosensing Techniques and Applications
- Microfluidic and Bio-sensing Technologies
Universidade do Porto
2016-2025
Rede de Química e Tecnologia
2016-2025
National Institute of Science and Technology Policy
2024
Instytut Chemii i Techniki Jądrowej
2020
Mahidol University
2020
Joint Research Centre
2020
Universitat de les Illes Balears
2007-2010
Northeastern University
2010
Universidade de São Paulo
2006
Universidade Católica Portuguesa
2000-2006
Abstract This project was aimed to identify the quenching chemistry of biologically important reactive oxygen and nitrogen species (ROS/RNS, including radicals), show antioxidant action against through H‐atom electron transfer reactions, evaluate ROS/RNS scavenging activity antioxidants with existing analytical methods while emphasizing underlying chemical principles advantages/disadvantages these methods. In this report, we focused on applications impact assays potentiating future research...
Alopecia is a dermatological disorder, commonly known as hair loss, which affects up to half of the Caucasian male population by middle age, and almost all (95%) men old age. Considering that alopecia so many people there currently no scientifically proven treatment with few side effects, new drug-delivery systems able improve therapy are urgently required. With this purpose in mind, present study aimed develop lipid nanoparticles (nanostructured carriers) ability incorporate deliver...
Around two million tons of olive oil are produced in Europe annually, with Portugal being among the top five European oil-producing countries. Olive production results a substantial amount waste form leaves. These discarded leaves contain valuable phenolic compounds antioxidant, anti-inflammatory, hypoglycaemic, neuroprotective, and antiproliferative properties. Due to their richness polyphenols health-promoting properties, can be considered potential functional food ingredient. Thus,...
Nanoparticle concentration and encapsulation efficiency (EE) are critical attributes for the efficacy/toxicity of nanoformulations human use. Consequently, their assessment at developmental stages is mandatory. However, complexity heterogeneity nanoparticles along with technical limitations available methods makes unfeasible use a single technique, transversal to different nanoparticle types, assessing each these parameters. Different techniques can be applied: measurement accuracy relies on...
Resveratrol was investigated in terms of its stability, biocompatibility and intestinal permeability across Caco-2 cell monolayers free form or encapsulated solid lipid nanoparticles (SLNs) nanostructured carriers (NLCs). SLNs NLCs presented a mean diameter between 160 190 nm, high negative zeta potential −30 mV resveratrol entrapment efficiency 80%, suggesting they are suitable for oral delivery. Nanoencapsulation effectively protected from photodegradation, MTT assays demonstrated that...
Background: Rheumatoid arthritis (RA) is an autoimmune disease with severe consequences for the quality of life sufferers. Regrettably, inflammatory process involved remains unclear, and finding successful therapies as well new means its early diagnosis have proved to be daunting tasks. As macrophages are strongly associated RA inflammation, effective therapy may encompass ability target these cells. In this work, a approach targeted imaging was developed based on use multifunctional...
The analysis and interpretation of data retrieved from Oxygen Radical Absorbance Capacity (ORAC) assays represent a challenging task. ORAC indexes originate different mathematical approaches often lacking correct elucidation kinetic features concerning radical scavenging reactions by antioxidant compounds. In this work, the expression values as area under fluorescein (FL) decay curves (AUC) lag time are critically compared. This multi-parametric showed extension beyond period for caffeic...
ABSTRACT Selenium is an essential trace element that can modulate the gut microbiome with impact on host health. The present study aimed to evaluate effects of organic (selenium-enriched yeast) vs inorganic (sodium selenite) selenium source fecal end-fermentation products and puppies from 20 52 weeks age. Alpha beta diversity bacterial community were affected by age but not gender or source. relative abundance taxa was differently age, DNA concentration all selected groups increased although...
Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and well-established risk factor for the development of cardiovascular (CVD). Gut dysbiosis may contribute to CVD inflammation CKD patients. Nonetheless, role gut blood microbiomes CKD-associated VC remains unknown. Therefore, this pilot study aimed explore link between patients on peritoneal dialysis (CKD-PD). Our results showed relative changes specific taxa CKD-PD with without VC, namely Coprobacter,...
Green and environmentally friendly approaches are increasingly necessary when developing new analytical methodologies. Electromembrane extraction (EME) has contributed to this by offering alternatives the traditional widely used plastic materials. Specially, those derived from biopolymers (such as agarose or chitosan) have recently gained a great importance in EME they biodegradable sustainable, which constitutes major advantage environmental impact of these processes. This review is...
In the present work, an automatic flow procedure based on multi-syringe injection analysis was developed for assessment of Folin−Ciocalteu reagent (FCR) reducing capacity in several types food products using gallic acid as standard. Different strategies mixing sample and were tested (continuous FCR, merging zones, intercalated zones approaches); lower consumption higher determination throughput attained approach (100 μL + 100 FCR). The application proposed method to compounds with known...