A5078364894- Neuroinflammation and Neurodegeneration Mechanisms
- Vasculitis and related conditions
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Barrier Structure and Function Studies
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Venous Thromboembolism Diagnosis and Management
- Bacterial Infections and Vaccines
- Cell Adhesion Molecules Research
- Autoimmune Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Infective Endocarditis Diagnosis and Management
- Reproductive System and Pregnancy
- Renal Diseases and Glomerulopathies
- Macrophage Migration Inhibitory Factor
- Health Systems, Economic Evaluations, Quality of Life
- Sarcoidosis and Beryllium Toxicity Research
- Regulation of Appetite and Obesity
- Ion channel regulation and function
- Meta-analysis and systematic reviews
- Nuclear Receptors and Signaling
University Hospital Münster
2018-2025
University of Münster
2014-2024
Klinik und Poliklinik für Neurologie
2019-2024
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Düsseldorf University Hospital
2021
University of Duisburg-Essen
2021
Heinrich Heine University Düsseldorf
2021
Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the thus promoting tissue However, post-ischemic immune response of compared to parenchyma remains poorly characterized. Here, we deeply characterize tissue-resident leukocytes in discover that respond differently stroke depending on their site residence. We thereby a unique phenotype myeloid cells exclusive These stroke-associated...
Abstract Although CSF analysis routinely enables the diagnosis of neurological diseases, it is mainly used for gross distinction between infectious, autoimmune inflammatory, and degenerative disorders CNS. To investigate, whether a multi-dimensional cellular blood characterization can support clinically similar we analysed 546 patients with neuroinflammatory, degenerative, or vascular conditions in cross-sectional retrospective study. By combining feature selection dimensionality reduction...
Sodium chloride promotes vascular fibrosis, arterial hypertension, pro-inflammatory immune cell polarization and endothelial dysfunction, all of which might influence outcomes following stroke. But despite enormous translational relevance, the functional importance sodium in pathophysiology acute ischemic stroke is still unclear. In current study, we show that high-salt diet leads to significantly worse outcomes, increased infarct volumes, a loss astrocytes cortical neurons While analyzing...
Background To evaluate the association of age with long-term outcome after thrombectomy. Methods In a retrospective cohort study based on routine healthcare data from Germany between 2010 and 2018, we included 18 506 patients acute ischaemic stroke treated mechanical Association mortality, disability, level care at 1 year was assessed. Results The median 76 years, 36.3% were aged ≥80 years 55.8% women. Patients compared those <80 had higher mortality (55.4% vs 28.5%; adjusted HR 1.13; 95%...
Background: Up to every fourth woman with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) suffers a clinically relevant relapse during pregnancy. High doses of steroids bear some serious risks, especially within the first trimester Immunoadsorption (IA) is an effective and more selective treatment option in disabling MS than plasma exchange. Data on use IA pregnancy breastfeeding are scarce. Methods: In this retrospective multicenter study, we analyzed safety...
Objective The objective of this study was to characterize patients with extracranial giant cell arteritis intracranial involvement. Methods In a multicenter retrospective study, we included 31 systemic (GCA) Clinical characteristics, pattern arterial involvement, and cytokine profiles were assessed. Patients GCA without involvement (n = 17), atherosclerosis 25) served as controls. Results Erythrocyte sedimentation rate (ESR) elevated in 18 (69.2%) 16 (100%) ( p 0.02). Headache complained by...
Abstract Background The neuroprotective and proangiogenic potential of ghrelin in acute ischemic stroke has been demonstrated experimental studies. However, the transferability these results is limited as was administered either before or very early after onset follow-up to first days stroke. aim this study therefore close extend knowledge gap. To end, we investigated effect two different translational animal models, one investigating long-term structural functional recovery Methods Middle...
Abstract Purpose Primary angiitis of the central nervous system (PACNS) is a heterogeneous, rare, and poorly understood inflammatory disease. We aimed at non-invasive imaging activated microglia/macrophages in patients with PACNS by PET-MRI targeting translocator protein (TSPO) [ 18 F]DPA-714 to potentially assist differential diagnosis, therapy monitoring, biopsy planning. Methods In total, nine ischemic stroke diagnosed or suspected underwent F]DPA-714-PET-MRI. Dynamic PET scanning was...
Alemtuzumab is an effective therapeutic option for patients with active forms of relapsing-remitting multiple sclerosis (RRMS).1 The adverse event profile comprises increased risk the development secondary autoimmune disorders as well infusion-associated reactions. infusion often associated acute cytokine release syndrome.2 Among other side effects, may experience headache, rash, pyrexia, and to a lesser extent hypotension, cardiac arrhythmia, rarely anaphylactic shock. These symptoms are...
Background and purpose Post‐ischaemic immune cell invasion into the brain is well characterized in animal stroke models contributes to neuronal damage. Therefore, it represents a promising therapeutic target. Cerebrospinal fluid ( CSF ) easily accessible may reflect cellular events within parenchyma. However, comprehensive studies on cells patients with are lacking. Methods In retrospective cohort study, we performed extensive immune‐cell profiling peripheral blood of acute ischaemic healthy...
Granulocyte-colony stimulating factor (G-CSF) and bone marrow derived mononuclear cells (BM-MNCs) have both been shown to improve functional outcome following experimental stroke. These effects are associated with increased angiogenesis neurogenesis. In the present study, we aimed determine synergistic of G-CSF BM-NMC treatment on long-term structural recovery after photothrombotic To model etiology stroke more closely, used spontaneously hypertensive (SH) rats in our experiment. Bone...
To distinguish between the genuine cellular impact of ischemic cascade by leukocytes and unspecific effects edema humoral components, two knock-in mouse lines were utilized. Mouse Y731F Y685F possess point mutations in VE-cadherin, which lead to a selective inhibition transendothelial leukocyte migration or impaired vascular permeability.
The "translational roadblock" between successful animal stroke studies and neutral clinical trials is usually attributed to conceptual weaknesses. However, we hypothesized that rodent cannot inform the human disease due intrinsic pathophysiological differences rodents humans., i.e., in infarct evolution.
Inflammatory causes of stroke are frequent and often pose diagnostic therapeutic challenges due to the scarcity randomized trials absence clear guideline recommendations for many scenarios. Following publication European Stroke Organization on primary angiitis central nervous system (PACNS) last year, German Neurological Society (DGN) has issued very guidelines this year diagnostics treatment PACNS updated systemic vasculitides; however, occurs not only as a result vascular inflammation but...
Background A dietary supplementation with conjugated linoleic acid (CLA) was shown to attenuate inflammation and increase the proportions of circulating regulatory T cells (T regs ) M2-type macrophages in disease models such as autoimmune encephalitis arteriosclerosis. Since anti-inflammatory (M2-type) were found enhance stroke recovery, we hypothesized that CLA-supplementation might improve recovery via immune modulatory effects. Methods Functional assessment performed over 90 days after...
Abstract Immigration and activation of immune cells play a significant role in damage progression after ischemic stroke. It has been shown that the nuclear receptor NR4A1 exerts crucial within inflammatory response various diseases via regulating cell activation. In this study, we investigated on recruitment brain resident peripheral cerebral ischemia. Here, show mediates an anti-inflammatory limiting effect stroke through immigrating neutrophil granulocytes. Importantly, NR4A1-activation...