A5072282782- Phytochemicals and Medicinal Plants
- Research on Leishmaniasis Studies
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Trypanosoma species research and implications
- Ethnobotanical and Medicinal Plants Studies
- Phytochemicals and Antioxidant Activities
- Carbohydrate Chemistry and Synthesis
- Natural Antidiabetic Agents Studies
- Plant Stress Responses and Tolerance
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Plant Genetic and Mutation Studies
- Plant pathogens and resistance mechanisms
- Studies on Chitinases and Chitosanases
- Seed and Plant Biochemistry
- Polyamine Metabolism and Applications
- Andrographolide Research and Applications
- Cassava research and cyanide
- Phytochemistry and biological activity of medicinal plants
- Protein Interaction Studies and Fluorescence Analysis
- Genetic and Environmental Crop Studies
- Parasitic Diseases Research and Treatment
- Plant Gene Expression Analysis
- GABA and Rice Research
Directorate of Medicinal and Aromatic Plants Research
2017-2025
Indian Institute of Horticultural Research
2018
Central Drug Research Institute
2012-2016
Rajasthan University of Veterinary and Animal Sciences
2016
University of Lucknow
2016
The high potential of quinazolinone containing natural products and their derivatives in medicinal chemistry led us to discover four novel series 53 compounds based on the concept molecular hybridization. Most synthesized analogues exhibited potent leishmanicidal activity against intracellular amastigotes (IC50 from 0.65 ± 0.2 7.76 2.1 μM) as compared miltefosine = 8.4 nontoxic toward J-774A.1 cell line Vero cells. Moreover, activation Th1 type suppression Th2 immune responses induction...
Antileishmanial activities of a library synthetic chalcone analogues have been examined. Among them, five compounds (11, 14, 16, 17, 22, and 24) exhibited better activity than the marketed drug miltefosine in vitro studies against intracellular amastigotes form Leishmania donovani. Three promising compounds, were tested L. donovani/hamster model. Oral administration at concentration 100 mg/kg body weight per day for 5 consecutive days, resulted >84% parasite inhibition 7 post-treatment it...
Background The development of a vaccine conferring long-lasting immunity remains challenge against visceral leishmaniasis (VL). Immunoproteomic characterization Leishmania donovani proteins led to the identification novel protein NAD+-dependent Silent Information regulatory-2 (SIR2 family or sirtuin) (LdSir2RP) as one potent immunostimulatory proteins. Proteins SIR2 are characterized by conserved catalytic domain that exerts unique NAD-dependent deacetylase activity. In present study, an...
SUMMARY Glucose-6-phosphate dehydrogenase (G6PD), a regulatory enzyme of the pentose phosphate pathway from Brugia malayi , was cloned, expressed and biochemically characterized. The Km values for glucose-6-phosphate nicotinamide adenine dinucleotide (NADP) were 0·25 0·014 m respectively. rBmG6PD exhibited an optimum pH 8·5 temperature, 40 °C. Adenosine 5′ [ γ -thio] triphosphate (ATP- -S), adenosine β -imido] -NH), diphosphate (ADP- Na + K Li Cu ++ ions found to be strong inhibitors...
The helicases are motor proteins participating in a range of nucleic acid metabolisms. RNA helicase families characterized by the presence conserved motifs. This article reports comprehensive silico analysis Bos taurus DExH/D members. Bovine were identified using domain sequences including 38 DDX (DEAD box) and 16 DHX (DEAH Signature motifs used for validation these proteins. Putative sub cellular localization phylogenetic relationship established. Comparative with human members was carried...
Lipid lowering activity of novel coumarin–indole hybrids has been demonstrated.
Velvet bean is an important medicinal legume, its seeds are prominent source of L-Dopa. The present investigation on genetic diversity assessment 58 germplasm velvet by using 11 ISSR markers. Out 63 amplified products 59 were showed polymorphism and 4 monomorphic with average 5.7 bands per primer. According to band statistics efficiency parameters the primers UBC 827, 834 836 more efficient. highest similarity values (0.90) observed between IIHR MP 102 74-3. In dendrogram grouped into two...
The Bihar hairy caterpillar, Spilarctia obliqua, is a dreaded and sporadic pest on several cash crops in the Oriental region. polyphagous feeding habit enables it to survive variety of crops. group caterpillars this study was found young plants sweet basil. Young larvae feed gregariously under surface leaves later solitary nature. Damage symptoms, as skeletonization upper epidermis leaves, were observed. identity species confirmed through morphological molecular methods (No. MK491177)....