A5089140314- Heavy Metal Exposure and Toxicity
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Urban Green Space and Health
- Air Quality and Health Impacts
- Trace Elements in Health
- Gestational Diabetes Research and Management
- Arsenic contamination and mitigation
- Heavy metals in environment
- Noise Effects and Management
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Pregnancy and Medication Impact
- Breastfeeding Practices and Influences
- Nutritional Studies and Diet
- Atmospheric chemistry and aerosols
- Urban Agriculture and Sustainability
- Maternal Mental Health During Pregnancy and Postpartum
- Urban Heat Island Mitigation
- Child Nutrition and Feeding Issues
- Impact of Light on Environment and Health
- Antibiotic Use and Resistance
- Toxic Organic Pollutants Impact
Harvard University
2017-2025
Harvard Pilgrim Health Care
2018-2025
Kaohsiung Medical University
2017-2019
Exposure to per- and polyfluoroalkyl substances (PFASs) may interfere with lipid regulation. However, most previous studies were cross-sectional the risk of reverse causation, suggesting a need for long-term prospective studies. We examined relationship baseline plasma PFAS concentrations repeated measures blood lipids. included 888 prediabetic adults from Diabetes Prevention Program (DPP) DPP Outcomes Study, who had measurements 6 at (1996–1999) lipids over 15 years follow-up, initially...
Metal exposure during pregnancy influences maternal and child health. Oxidative stress inflammation may mediate adverse effects of heavy metals, whereas essential metals act as antioxidants. Mitochondrial DNA is a prime target for metal-induced oxidative damage. Telomere dysfunction attributed to imbalances between reactive oxidant species antioxidants.We evaluated individual joint associations prenatal with mitochondrial copy number (mtDNAcn) telomere length (TL) in cord blood biomarkers...
Antidepressants are among the most commonly prescribed medications, but evidence on comparative weight change for specific first-line treatments is limited.
<h3>Importance</h3> Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are ubiquitous synthetic chemicals that suspected endocrine disruptors. <h3>Objectives</h3> To determine the extent to which PFASs associated with increases in weight body size evaluate whether a lifestyle intervention modifies this association. <h3>Design, Setting, Participants</h3> This prospective cohort study included 957 individuals who participated Diabetes Prevention Program trial, conducted from July 1996 May...
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are suspected endocrine disruptors widely detected across populations. We examine the extent to which PFASs associated with diabetes incidence microvascular disease. Secondarily, we tested whether a lifestyle intervention modifies associations decreases concentrations.
Diet is assumed to be the main source of exposure per- and polyfluoroalkyl substances (PFAS) in non-occupationally exposed populations, but studies on diet-PFAS relationship United States are scarce. We extracted multiple dietary variables, including daily intakes food group, diet scores, patterns, from self-reported data collected at baseline (1996–1999) adults with pre-diabetes enrolled Diabetes Prevention Program, used linear regression models evaluate relationships each variable plasma...
Diet is thought to account for most adult human exposure per- and polyfluoroalkyl substances (PFAS). Children are particularly vulnerable adverse health effects of PFAS may have different eating habits than adults. However, studies dietary patterns in children limited. We studied 548 Boston-area with food frequency questionnaire data (89 items) early childhood (median age 3.3 years) plasma concentrations 6 quantified mid-childhood 7.7 years). used univariate linear regression examine...
Understanding the temporal trends and change of concentrations per- polyfluoroalkyl substances (PFAS) is important to evaluate health impact PFAS at both individual- population-level, however, limited information available for pre-diabetic adults in U.S. Determine rate plasma overweight or obese variation by sex, race/ethnicity, age. We described using samples collected 1996–1998, 1999–2001, 2011–2012 from 957 enrolled Diabetes Prevention Program (DPP) trial Outcomes Study (DPPOS) compared...
Background: Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, few large studies have focused on autism-related outcomes. We investigated whether blood concentrations of PFAS in pregnancy are associated child Methods: included 10 cohorts from the National Institutes Health (NIH)-funded Environmental influences Child Outcomes (ECHO) program (n = 1,429). measured 14 analytes maternal collected during...
Findings on the associations between prenatal PFAS exposures and offspring adiposity are inconsistent. Whether such may extend to adolescence is especially understudied.
Importance Limited access to healthy foods, resulting from residence in neighborhoods with low food access, is a public health concern. The contribution of this exposure early life child obesity remains uncertain. Objective To examine associations neighborhood during pregnancy or childhood body mass index (BMI) and risk. Design, Setting, Participants Data cohorts participating the US nationwide Environmental Influences on Child Health Outcomes consortium between January 1, 1994, March 31,...
Protective associations of greenspace with Parkinson's disease (PD) have been observed in some studies. Visual exposure to seems be important for the proposed pathways underlying these associations. However, most studies use overhead-view measures (e.g., satellite imagery, land-classification data) that do not capture street-view and cannot distinguish between specific types. We aimed evaluate hospitalizations a PD diagnosis code (PD-involved hospitalization).
Dietary patterns during pregnancy have been shown to influence the development of gestational diabetes mellitus (GDM). However, evidence from Asian populations is limited and inconsistent. We conducted a prospective cohort study in China assess relationship between dietary GDM. administered three-day food diaries (TFD) frequency questionnaires (FFQ) at second trimester. GDM was diagnosed with 75 g 2-h oral glucose tolerance test 24–28 weeks gestation. identified using principal components...
Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in populations worldwide may hinder kidney function. The objective of the study was to determine longitudinal associations plasma PFAS concentrations with estimated glomerular filtration rate (eGFR) evaluate whether a lifestyle intervention modify associations. We studied 875 participants initially randomized or placebo arms Diabetes Prevention Program (DPP, 1996-2002) trial Outcomes Study (DPPOS, 2002-2014). ran...
Prenatal exposure to metals has been individually associated with birth outcomes. However, little is known about the effect of metal mixture, particularly at low levels.To estimate individual and joint effects mixture components on outcomes.We used data from 1,391 mother-infant pairs in Project Viva (1999-2002). We measured 11 maternal 1st trimester erythrocyte; abstracted weight medical records; calculated gestational age last menstrual period or ultrasound; obtained length (n = 729) head...
Background: The developing fetal brain is sensitive to many environmental exposures. However, the independent and joint effects of prenatal exposure metals micronutrients on child cognition are not well understood. Objectives: Our aim was evaluate associations first-trimester (∼10 wk) maternal erythrocyte concentrations mixtures nonessential essential with early (∼3 y) mid-childhood (∼8 cognitive test scores in Project Viva, a prebirth cohort Boston, Massachusetts, USA. Methods: We measured...
The relationship of plasma concentration per- and polyfluoroalkyl substances (PFAS) with blood pressure (BP) is uncertain. This study examined cross-sectional prospective associations PFAS BP hypertension. We quantified concentrations from 957 participants enrolled in the lifestyle placebo arms Diabetes Prevention Program (DPP), a randomized controlled trial approximately 15 years follow-up. used multivariable linear logistic regressions to test six PFAS, including perfluorooctanesulfonic...
Metals are involved in glucose metabolism, and some may alter glycemic regulation. However, joint effects of essential non-essential metals on concentrations during pregnancy unclear. This study explored the associations exposures to (copper, magnesium, manganese, selenium, zinc) (arsenic, barium, cadmium, cesium, lead, mercury) with gestational using 1,311 women enrolled 1999-2002 Project Viva, a Boston, MA-area cohort. The measured erythrocyte metal from 1
Hypertensive disorders of pregnancy (HDP) such as preeclampsia and gestational hypertension are major contributors to maternal child morbidity mortality. Previous studies have reported associations with selected metals vitamins but limited in sample size non-prospective study designs. We evaluated prospective metal mixtures HDP tested interactions by vitamins. measured first trimester (median = 10.1 weeks) concentrations essential (copper, magnesium, manganese, selenium, zinc) nonessential...
A locally validated tool was needed to evaluate long-term dietary intake in rural Bangladesh. We assessed the validity of a 42-item dish-based semi-quantitative food frequency questionnaire (FFQ) using two 3-day diaries (FDs). selected random subset 47 families (190 participants) from longitudinal arsenic biomonitoring study Bangladesh administer FFQ. Two FDs were completed by female head households and we used an adult male equivalent method estimate FD for other participants. Food nutrient...
Abstract Background Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of biotransformation and elimination may influence the susceptibility toxicity. Therefore, we examined determinants metabolism pregnant women in Bangladesh who are exposed to high levels arsenic. Methods In a prospective birth cohort, followed 1613 collected urine samples at two prenatal visits: one 4–16 weeks, second 21–37 weeks pregnancy. We measured major species...
Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that have been associated with cardiovascular risk factors including elevated body weight hypercholesterolemia. Therefore, PFAS may contribute to the development of atherosclerosis disease (CVD). However, no previous study has evaluated associations between exposure arterial calcification.This used data from 666 prediabetic adults enrolled in Diabetes Prevention Program trial who had six quantified plasma at...
Food and nutrition-related factors have the potential to impact development of autism spectrum disorder (ASD) quality life for people with ASD, but gaps in evidence exist. On November 10, 2022, Tufts University's Friedman School Nutrition Science Policy Innovation Institute hosted a one-day meeting explore regarding relationships food nutrition ASD. This report summarizes presentations deliberations from meeting. Topics addressed included prenatal child dietary intake, microbiome, obesity,...