A5009650321- Bone Tissue Engineering Materials
- Horticultural and Viticultural Research
- Fermentation and Sensory Analysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Calcium Carbonate Crystallization and Inhibition
- Plant biochemistry and biosynthesis
- Graphene and Nanomaterials Applications
- Phytochemicals and Antioxidant Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Plant Physiology and Cultivation Studies
- Probiotics and Fermented Foods
- Phosphorus and nutrient management
- Collagen: Extraction and Characterization
- Clay minerals and soil interactions
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Postharvest Quality and Shelf Life Management
- Electrospun Nanofibers in Biomedical Applications
- Polydiacetylene-based materials and applications
- Supramolecular Self-Assembly in Materials
- Layered Double Hydroxides Synthesis and Applications
- Dental materials and restorations
- Nanoparticles: synthesis and applications
- Antimicrobial agents and applications
Universidad de Granada
2018-2024
University of Insubria
2019-2020
National Research Council
2014-2018
Institute of Science and Technology for Ceramics
2014-2018
Consejo Superior de Investigaciones Científicas
2012-2014
Consorzio Roma Ricerche
2014
Ospedale per gli Infermi
2014
Instituto Andaluz de Ciencias de la Tierra
2014
Inhalation delivers drug-loaded nanoparticles to the heart, improving cardiac function in murine and porcine models.
Biomimetic calcium phosphate nanoparticles (CaP) have been actively used in biomedicine, due to their high biodegradability and biocompatibility. However, much less progress has made regarding application precision agriculture, i.e., for the controlled delivery of active species plants. Herein, we report a straightforward green synthetic method dope CaP with potassium (K) nitrogen (N, as nitrate urea). By modulating conditions terms maturation time (at 37 °C) doping, prepared K- N-doped form...
Abstract Demineralization of dental hard tissue is a widespread problem and the main responsible for caries dentin hypersensitivity. The most promising strategies to induce precipitation new mineral phase are application materials releasing gradually Ca 2+ PO 4 3− ions or mimicking host tissue. However, design formulations covering both processes so far challenge in preventive dentistry. In this work, we have synthesized innovative biomimetic amorphous calcium phosphate (ACP), which has...
To develop biocompatible and bioresorbable negatively charged calcium phosphate nanoparticles (CaP-NPs) as an innovative therapeutic system for the delivery of bioactive molecules to heart.CaP-NPs were synthesized via a straightforward one-pot biomineralization-inspired protocol employing citrate stabilizing agent regulator crystal growth. CaP-NPs administered cardiac cells in vitro effects treatments assessed. vivo microRNAs was evaluated.CaP-NPs efficiently internalized into cardiomyocytes...
Abstract Nanosized fertilizers are the new frontier of nanotechnology towards a sustainable agriculture. Here, an efficient N-nanofertilizer is obtained by post-synthetic modification (PSM) nitrate-doped amorphous calcium phosphate (ACP) nanoparticles (NPs) with urea. The unwasteful PSM protocol leads to N-payloads as large 8.1 w/w%, well replicated using inexpensive technical-grade reagents for cost-effective up-scaling and moderately favours urea release slowdown. Using approach, N amount...
Antimicrobial resistance has become a major problem over the years and threatens to remain in future, at least until solution is found. Silver nanoparticles (Ag-NPs) antimicrobial polymers (APs) are known for their properties can be considered an alternative approach fighting resistant microorganisms. Hence, main goal of this research shed some light on Ag-NPs APs (chitosan (CH), poly-L-lysine (PLL), ε-poly-L-lysine (ε-PLL), dopamine (DA)) when used alone complexed explore potential...
Abstract Bio-inspired synthetic calcium phosphate (CaP) nanoparticles (NPs), mimicking the mineral component of bone and teeth, are emergent materials for sustainable applications in agriculture. These sparingly soluble salts show self-inhibiting dissolution processes undersaturated aqueous media, control at molecular nanoscale levels which is not fully elucidated. Understanding mechanisms particle highly relevant to efficient delivery macronutrients plants crucial developing a valuable...
Abstract BACKGROUND The use of nanomaterials for the efficient delivery active species in viticulture is still an unexplored opportunity. Nitrogen, essential nutrient grapevine development and wine quality, commonly provided form urea. However, application conventional fertilisers contributes to nitrate leaching denitrification, thus polluting groundwater causing a serious environmental impact. Nanotechnology offering smart solutions towards more sustainable agriculture. In present work, we...
Nanotechnology is emerging as a very promising tool towards more efficient and sustainable practices in agriculture. In this work, we propose the use of non-toxic calcium phosphate nanoparticles doped with urea (U-ACP) for fertilization Triticum durum plants. U-ACP present similar morphology, structure, composition than amorphous precursor bone mineral, but contain considerable amount nitrogen adsorbed (up to ca. 6 wt % urea). Tests on plants indicated that yields quality crops treated at...
Calcium phosphate nanoparticles were doped with zinc ions to produce multifunctional nanomaterials for efficient agronomic fortification and protection of plants. The resulting round-shaped (nanoZn) composed 20.3 wt % Ca, 14.8 P, 13.4 Zn showed a pH-controlled solubility. NanoZn stable in aqueous solutions at neutral pH but dissolved citric acid 4.5 (i.e., the inside tomato fruits), producing pH-responsive delivery essential nutrients Zn. In fact, foliar application nanoZn on plants provided...
Although agrochemical practices can enhance agricultural productivity, their intensive application has resulted in the deterioration of ecosystems. Therefore, it is necessary to develop more efficient and less toxic methods against pests infections while improving crop productivity. Moving toward sustainable development, this work, we originally described preparation a composite (ZIF-8@HA) consisting coating zeolitic-like metal-organic framework (MOF) ZIF-8 (based on Zn, an essential...
Citrate plays a dual role in the apatite crystallization: driving growth pathway <italic>via</italic> an amorphous precursor and controlling nanocrystal size by non-classical oriented aggregation.
We designed nanoparticles able to protect the elicitor on leaves of grapevines over long periods time. The foliar application this nanoelicitor produced wines with high content stilbenes at significantly reduced dosages.
Foliar application of nitrogen can increase readily assimilable in grapes without increasing vegetative growth and yield. Recently, nano-formulations have been used to achieve a controlled precise release agrochemicals, avoiding losses due degradation volatilisation that could cause environmental problems. In this study, foliar urea treatments were applied Monastrell grapevines two different formats during three consecutive seasons. The administered at veraison one week later, consisting...
The time-evolution of calcium phosphate precipitation by vapor diffusion has been studied in situ confocal Raman microspectroscopy. A hanging drop configuration within a device known as "crystallization mushroom" was employed order to improve the signal coming from growing crystals. This innovative methodology allowed identify and follow evolution precipitates formed at different areas drops containing mixed solutions Ca(CH3COO)2 (NH4)2HPO4 due CO2 NH3 gases released NH4HCO3 concentrations...
The occurrence of an amorphous calcium phosphate layer covering the crystalline apatite core has been suggested to be intrinsic feature both bone mineral and synthetic biomimetic analogs. However, exahustive quantitative picture amorphous-crystalline relationship in these materials is still missing. Here, we present a multiple scale modelling that combines small-angle X-ray scattering (SAXS) synchrotron wide-angle total (WAXTS) analyses investigate spatial interplay sample carbonated...
Nitrogen composition on grapevines has a direct effect the quality of wines since it contributes to develop certain volatile compounds and assists in correct kinetics alcoholic fermentation. Several strategies can be used ensure nitrogen content grapes one them could use elicitors such as methyl jasmonate. The this elicitor been proven efficient production secondary metabolites which increases wines, but its also some drawbacks low water solubility, high volatility, expensive cost. This...
The need of synthetic bone grafts that recreate from macro- to nanoscale level the biochemical and biophysical cues extracellular matrix has been a major driving force for development new generation biomaterials. In this study, substitutes have synthesized via biomimetic mineralization recombinant collagen type I-derived peptide (RCP), enriched in tri-amino acid sequence arginine-glycine-aspartate (RGD). Three-dimensional (3D) isotropic porous scaffolds three different compositions are...