A5028334836- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV Research and Treatment
- Health and Medical Studies
- Vaccine Coverage and Hesitancy
- Migration, Health and Trauma
- Sex work and related issues
- Homelessness and Social Issues
- HIV/AIDS drug development and treatment
- Child and Adolescent Health
- Bacillus and Francisella bacterial research
- Data-Driven Disease Surveillance
- Medical and Health Sciences Research
- Pediatric health and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Outbreaks Research
- Frailty in Older Adults
- Pressure Ulcer Prevention and Management
- Diverse Legal and Medical Studies
- Influenza Virus Research Studies
- Health Promotion and Cardiovascular Prevention
Robert Koch Institute
2016-2025
Bern University of Applied Sciences
2025
Highlights•Chronic HCV prevalence and treatment rates among PWID vary widely across Europe.•HCV scale-up is required in most sites to reduce transmission.•Increasing OST/NSP coverage enhances prevention benefit.Graphical abstractAbstractBackground & AimsPrevention of hepatitis C virus (HCV) transmission people who inject drugs (PWID) critical for eliminating Europe. We estimated the impact current scaled-up with without scaling up opioid substitution therapy (OST) needle syringe programmes...
Nowadays, dried blood spots (DBS) are primarily used to obtain diagnostic access risk collectives such as intravenous drug users, who prone infections with hepatitis B virus (HBV), C (HCV), and human immunodeficiency (HIV). Before DBS analyses can be in this context, however, a comprehensive evaluation of its performance characteristics must conducted. To the best our knowledge, current study presents for first time essential data Abbott ARCHITECT system, which is currently worldwide leading...
People who inject drugs (PWID) are at increased risk of acquiring and transmitting HIV Hepatitis C (HCV) due to sharing injection paraphernalia unprotected sex. To generate seroprevalence data on HCV among PWID related behaviour, a multicentre sero- behavioural survey using respondent driven sampling (RDS) was conducted in eight German cities between 2011 2014. We also evaluated the feasibility effectiveness RDS for recruiting study cities. Eligible participation were people had injected...
Epidemiological data are crucial to monitoring progress towards the 2030 Hepatitis C Virus (HCV) elimination targets. Our aim was estimate prevalence of chronic HCV infection (cHCV) in European Union (EU)/European Economic Area (EEA) countries 2019. Multi-parameter evidence synthesis (MPES) used produce national estimates cHCV defined as: π = πrecρrec + πexρex πnonρnon; πrec, πex, and πnon represent among recent people who inject drugs (PWID), ex-PWID, non-PWID, respectively, while ρrec,...
Injection anthrax was described first in 2000 a heroin-injecting drug user Norway. New cases among heroin consumers were detected the United Kingdom (52 cases) and Germany (3 2009-10. In June 2012, fatal case occurred Regensburg, Bavaria. As of December 13 had been reported this new outbreak from Germany, Denmark, France Kingdom. We analysed isolates 2009-10 2012 as well injection Norway by comparative molecular typing using high resolution 31 marker multilocus variable-number tandem repeat...
Background The variety and limitations of current laboratory methods for estimating HIV-incidence has driven attempts to improve standardize the performance serological ‘Tests Recent HIV-Infections’ (TRI). Primary follow-up HIV-1 positive plasma samples from individuals with well-defined dates infection collected as part German Seroconverter Cohort provided specimens highly suitable use in comparing three TRIs: AWARE™ BED™ EIA Incidence test (BED-CEIA), Genetic systems HIV-1/HIV-2 Plus O...
Abstract Background In Germany, risk of hepatitis C virus (HCV) infection is highest among people who inject drugs (PWID). New injectors (NI) are particularly vulnerable for HCV-acquisition, but little known about health seeking behaviour and opportunities intervention in this group. We describe characteristics, HCV prevalence, estimated incidence awareness HCV-status NIs missed testing. Methods People had injected the last 12 months were recruited into a cross-sectional serobehavioural...
According to the definition of German Federal Statistical Office, about every fourth person living in Germany has a so-called migration background (MB), i.e., or at least one their parents was born without citizenship. However, MB been defined differently many studies. Also, summarises people different situations, making differentiated analysis health science more difficult. This article formulates recommendations for collection and migration-related, as well social structural, determinants...
Hepatitis B (HBV) and hepatitis C (HCV) viral infections are uncommon in Germany, though these have a higher prevalence among certain subpopulations, such as some first-generation migrant groups, people who inject drugs (PWID), HIV-positive men sex with (HIV+MSM). Repeated estimates of the number infected HBV HCV essential to facilitate monitoring elimination efforts by 2030. We estimated total each specific subpopulation. based our calculations on data from 2013, year that we strategically...
Blood cultures from a heroin user who died in June 2012, few hours after hospital admission, due to acute septic disease, revealed the presence of Bacillus anthracis. This report describes extended diagnosis by MALDI-TOF and real-time PCR rapid confirmation anthrax infection through reference laboratories. Physicians diagnostic laboratories were informed alerted efficiently reporting channels German public health institutions, which is essential for prevention further cases.
The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed cases by laboratories. Because the time between infection and diagnosis varies widely persons, it difficult to determine number recent among HIV. In Germany, BED-capture-enzyme immunoassay (BED-CEIA) has been used distinguish long-standing infection. aim this analysis report proportion 2008 2014 identify factors associated with infections.A sample voluntary laboratories all diagnostic was...
Two COVID-19 outbreaks occurred in residential buildings with overcrowded housing conditions the city of Göttingen Germany during May and June 2020, when infection incidences were low across rest country, a national incidence 2.6/100,000 population. The increased local to 123.5/100,000 2020. Many affected residents living precarious experienced language barriers. characterized by high case numbers attack rates among residents, many asymptomatic cases, comparatively young population,...
ObjectivesTo describe the characteristics of a large hepatitis A virus (HAV) outbreak among men who have sex with (MSM) in Berlin and to assess impact measures implemented.MethodsCases laboratory-confirmed, symptomatic HAV infection notified Berlin, Germany between August 2016 February 2018 were analysed using routine enhanced surveillance data including genotyping results. Several studies involving different groups participants conducted further investigate outbreak, surveys on knowledge...
People who inject drugs are at high risk for hepatitis B, C and HIV. HTLV was reported by neighboring countries to be prevalent in this population, but the situation Germany is unclear. To generate seroprevalence related behavioural data enhance prevention efforts against these infections drug users Germany, a multicentre sero- survey initiated. not well reached services testing counselling blood-borne Germany. An interventional part of study intended prove feasibility acceptance...
Abstract Background People who inject drugs (PWID) are at high risk of blood-borne infections, and injection drug use contributes significantly to hepatitis C virus (HCV) transmission. The WHO has therefore set targets reducing HCV incidence prevalence among PWID increasing treatment coverage eliminate by 2030. DRUCK study (2011–2014) found low in Germany. To assess progress the elimination PWID, we conducted a cross-sectional two German federal states that piloted future monitoring. Methods...
Serological methods exist that allow differentiating between recent and long-standing infections in persons infected with HIV. During a pilot study Berlin 2005 2007 methodologies have been evaluated. In cross-sectional blood samples, demographic, laboratory, clinical behavioural data based on KABP survey were collected from patients newly diagnosed HIV infections. The BED-CEIA was used to determine recency of infection. Recent contributed 54% (CI [95%]: 45; 64) MSM 16% 0; 39) other...