A5012627137- HIV, Drug Use, Sexual Risk
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Molecular Biology Techniques and Applications
- Health and Medical Studies
- Genital Health and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Sex work and related issues
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Antibiotic Use and Resistance
- Exercise and Physiological Responses
- Reproductive tract infections research
- Viral Infections and Outbreaks Research
- Pharmaceutical Economics and Policy
- COVID-19 Impact on Reproduction
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Antiplatelet Therapy and Cardiovascular Diseases
- HIV/AIDS Impact and Responses
- Ovarian cancer diagnosis and treatment
- Toxoplasma gondii Research Studies
Robert Koch Institute
2019-2024
European Centre for Disease Prevention and Control
2021-2022
Institute for Applied Economic Research
2021
Charité - Universitätsmedizin Berlin
2018-2021
Freie Universität Berlin
2018-2020
Humboldt-Universität zu Berlin
2018-2020
Nigeria Centre for Disease Control
2019
African Field Epidemiology Network
2019
Centers for Disease Control and Prevention
2019
World Health Organization - Nigeria
2019
Introduction This population-based study aimed to fill the knowledge gap on Human Papillomavirus (HPV) prevalence and associated sociodemographic risk factors of general population in North Tongu District, Ghana. These results are needed guide cervical cancer prevention efforts, as leading type female cancers. Methods A cross-sectional including 2002 women Ghana investigated HPV factors. Women were recruited by geographical distribution through local community-based health system samples...
Abstract Invasive listeriosis is a severe foodborne infection in humans and difficult to control. Listeriosis incidence increasing worldwide, but some countries have implemented molecular surveillance programs improve recognition management of outbreaks. In Germany, routine whole-genome sequencing, core genome multilocus sequence typing, single nucleotide polymorphism calling are used for subtyping Listeria monocytogenes isolates from cases suspected foods. During 2018–2019, an unusually...
Marrow adipose tissue (MAT) is unique with respect to origin, metabolism, and function. MAT characterized high heterogeneity which correlates skeletal location bone metabolism. This fat depot also highly sensitive various hormonal, environmental, pharmacologic cues it responds changes in volume and/or metabolic phenotype. We have demonstrated previously that has characteristics of both white (WAT) brown (BAT)-like or beige tissue, phenotype attenuated aging diabetes. Here, we extended our...
Epidemiological data are crucial to monitoring progress towards the 2030 Hepatitis C Virus (HCV) elimination targets. Our aim was estimate prevalence of chronic HCV infection (cHCV) in European Union (EU)/European Economic Area (EEA) countries 2019. Multi-parameter evidence synthesis (MPES) used produce national estimates cHCV defined as: π = πrecρrec + πexρex πnonρnon; πrec, πex, and πnon represent among recent people who inject drugs (PWID), ex-PWID, non-PWID, respectively, while ρrec,...
Abstract We reviewed data pertaining to the massive wave of Lassa fever cases that occurred in Nigeria 2018. No new virus strains were detected, but 2018, outbreak response was intensified, additional diagnostic support available, and surveillance sensitivity increased. These factors probably contributed high case count.
The paradigm shift from cytological screening to Human Papillomavirus (HPV)-based for cervical cancer allows the introduction of new technologies in sample collection and diagnostics. OncoE6™ Cervical Test (OncoE6 Test) is a rapid, easy-to-use lateral flow method detecting HPV16/18 E6 oncoproteins that has proven detect high-grade lesions with high specificity. If compatible self-collection samples, this technology might allow decentralized hard-to-reach populations. For technical...
Abstract Toxoplasmosis is a zoonotic infection contracted through Toxoplasma gondii–contaminated food, soil, or water. Seroprevalence in Germany high, but estimates of disease incidence are scarce. We investigated incidences for various toxoplasmosis manifestations using anonymized healthcare claims data from 2011–2016. Patients with diagnosis during the annual observational period were considered incident. The estimated was adjusted to general population age/sex distribution. an average...
HPV DNA Array is an E1-targeting PCR genotyping test, with capability of distinguishing 18 high-risk (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) and 11 low-risk types (6, 11, 40, 42, 44, 54, 67, 69, 70, 85, 97). uses multiplex for E1-gene sequence amplification. The amplicons are detected genotyped by reverse hybridization to immobilized probes spotted as triplets in single 96 well-plate wells read AID ELISPOT reader. Aim the study was evaluate clinical...
Co-infection with Hepatitis C virus (HCV) among HIV-positive patients leads to accelerated progression of liver disease and AIDS. Due increased HCV prevalence incidence, co-infection requires monitoring trends individuals. This will help target prevention strategies support reach the global goals eliminating viral hepatitis as a public health threat. In this analysis incidence were determined for years 1996-2019 from yearly blood samples questionnaire details HIV-1-positive patients,...
Cervical cancer is the second most common among Ghanaian women and screening coverage low. ACCESSING a cross-sectional study investigating human papillomavirus (HPV) prevalence via self-sampling in rural communities of North Tongu district Ghana. Female health-care providers (HCPs) were invited to self-collect cervicovaginal sample with commercial sampler order acquaint themselves sampling method.This set out explore female HCPs' perceptions, advocacy for, implications aim enhancing...
In care of people living with human immunodeficiency virus (HIV), early diagnosis infection is one the greatest challenges remaining. A promising approach to increase could be optimized HIV testing in persons indicator conditions (ICs). ICs are which AIDS-defining HIV, that may have significant adverse consequences for individual's clinical management if presence not detected, and an (undiagnosed) prevalence ≥0.1%.
Abstract Background People who inject drugs (PWID) are at high risk of blood-borne infections, and injection drug use contributes significantly to hepatitis C virus (HCV) transmission. The WHO has therefore set targets reducing HCV incidence prevalence among PWID increasing treatment coverage eliminate by 2030. DRUCK study (2011–2014) found low in Germany. To assess progress the elimination PWID, we conducted a cross-sectional two German federal states that piloted future monitoring. Methods...
Persistent Human Papillomavirus (HPV) infection is a prerequisite for cervical cancer development. Few studies investigated clearance of high-risk HPV in low-and-middle-income countries. Our study and persistence over four years women from North Tongu District, Ghana. In 2010/2011, swabs 500 patients were collected genotyped (nested multiplex PCR) Accra, 2014, 104 who previously tested positive remained untreated re-tested HPV. Cytobrush samples (GP5+/6+ PCR & Luminex-MPG readout) Berlin,...
Abstract Background To reach the global elimination goals of viral hepatitis B and C (HBC, HCV), human immunodeficiency virus (HIV) other sexually transmitted infections as a public health threat by 2030, monitoring is needed. Staff members drug services opioid substitution treatment (OST) practices in Berlin Bavaria recruited clients for pilot study addressing respective among people who injected drugs (PWID) Germany, 2021/2022. Participants filled questionnaire were tested HBV, HCV, HIV...
Abstract Background Despite the potentially accompanying negative clinical, epidemiologic, and health economic effects, a large proportion of persons living with human immunodeficiency virus (HIV) are diagnosed late. Internationally, numerous diseases known to be HIV indicator diseases. Adequate testing in presence could help diagnose unknown infections earlier. The objective HeLP study is validate published for German setting identify guidelines terms these order reduce knowledge gaps...
Abstract Objectives Viral hepatitis co‐infection among people living with HIV is known to accelerate the progression of liver disease and AIDS. An increased prevalence incidence B virus (HBV) infection demands continuous monitoring adapt targeted prevention strategies reach global goals eliminating viral as a public health threat. Methods We determined HBV for years 1996–2019 from yearly blood sample testing questionnaire reports belonging nationwide, multicentre observational, prospective...
<b><i>Background:</i></b> Cervical cancer is caused by a persistent infection of human papillomavirus (HPV). Therefore, tests which detect the carcinogenic virus can be used for cervical screening. <b><i>Objective:</i></b> This first evaluation HPV DNA Array (AID Diagnostika, Strassberg, Germany), an E1-based genotyping polymerase chain reaction (PCR) test identification 29 types (6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 44, 45, 51, 52, 53,...
To prevent the transmission of blood-borne infections and reach elimination viral hepatitis by 2030, World Health Organization (WHO) has set goal to distribute 300 sterile needles syringes each year per person who injects drugs (PWID). We aimed assess drug paraphernalia distribution in Germany 2021, including WHO indicator, analyse changes measured 2018.We conducted a repeated cross-sectional study low-threshold services Germany. assessed type quantity distributed number supplied PWID 2021...
Human papillomavirus (HPV) detection is used for screening of cervical cancer and genotype-specific persistence has shown to be mandatory dysplasia development. Aim this study was evaluate the clinical performance HPV DNA Array intraepithelial neoplasia 2+ (CIN2+) lesion detection. a polymerase chain reaction-based assay that targets E1 sequences 29 types (6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 44, 45, 51, 52, 53, 54, 56, 58, 59, 66, 67, 68, 69, 70, 73, 82, 85, 97). The evaluation...