A5052708935- Nematode management and characterization studies
- Evolution and Genetic Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Parasite Biology and Host Interactions
- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Insect symbiosis and bacterial influences
- Genetic and phenotypic traits in livestock
- Plant and animal studies
- Genetic diversity and population structure
- Fish Ecology and Management Studies
- Liver Disease Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Ginger and Zingiberaceae research
- Animal Nutrition and Physiology
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Pancreatic function and diabetes
- Genetic Mapping and Diversity in Plants and Animals
- Ubiquitin and proteasome pathways
- Nosocomial Infections in ICU
- Organ Transplantation Techniques and Outcomes
- Carcinogens and Genotoxicity Assessment
Guangxi Academy of Agricultural Science
2023
Biodiversity Research Center, Academia Sinica
2019-2023
Xiangya Hospital Central South University
2019-2020
Central South University
2019-2020
Guiyang Medical University
2020
Max Planck Institute for Evolutionary Biology
2015-2019
Creative Commons
2019
Ministry of Education of the People's Republic of China
2017
Zhejiang University
2017
Women's Hospital, School of Medicine, Zhejiang University
2017
The patterns of genomic divergence during ecological speciation are shaped by a combination evolutionary forces. Processes such as genetic drift, local reduction gene flow around genes causing reproductive isolation, hitchhiking selected variants, variation in recombination and mutation rates all factors that can contribute to the heterogeneity divergence. On basis 60 fully sequenced three-spined stickleback genomes, we explore these different mechanisms explaining across five parapatric...
Abstract The observation of habitat‐specific phenotypes suggests the action natural selection. three‐spined stickleback ( Gasterosteus aculeatus ) has repeatedly colonized and adapted to diverse freshwater habitats across northern hemisphere since last glaciation, while giving rise recurring associated with specific habitats. Parapatric lake river populations sticklebacks harbour distinct parasite communities, a factor proposed contribute adaptive differentiation between these ecotypes....
Although micronuclei (MNi) have been extensively used to evaluate genotoxic effects and chromosome instability, the most basic issue regarding their formation was not completely addressed until recently, due limitations of traditional experimental methods. The development live-cell imaging, combined with genetically engineered labelling techniques makes it possible investigate origin a micronucleus in single cell real-time high-throughput manner. Here, we review all available studies on...
The genetic regulation of the plasma proteome has been extensively studied in adult populations, yet protein quantitative trait loci (pQTL) studies children and adolescents remain largely unexplored. Here, we mapped pQTLs for 178 proteins measured using affinity-based proteomics 3,853 Danish (44.1% boys; median age 11.6 years) from HOLBAEK Study. We aimed to identify context-dependent pQTLs, where variant-protein associations varied across biological contexts such as obesity, puberty, sex....
Background p53 abnormality and aneuploidy often coexist in human tumors, tetraploidy is considered as an intermediate between normal diploidy aneuploidy. The purpose of this study was to investigate whether how influences the transformation from Principal Findings Live cell imaging performed determine fates mitotic behaviors several mouse tetraploid cells with different status, centrosome spindle immunostaining used behaviors. We found that dominant-negative mutation, point or knockout led a...
Abstract Introduction: Choice of treatment in patients with symptomatic polycystic liver diseases (PLD) remains controversial. Various surgical procedures aiming at eliminating cysts are widely used mild and advanced PLD patients, but transplantation is currently recommended as the only curative especially severe cases. Patient concerns: Case 1: A 51-year-old male was admitted for eating disorder dyspnea 2 months. He had been diagnosed PLD, PKD, hypertension 9 years, antihypertensive drug...
The passion fruit peel (PFP) is the by-product of juice processing and rich in phenolic compounds dietary fibers. As high ADF content PFP (34.20%), we proceeded to treat with cellulase. decreased 16.70% after enzymatic processing, supposed that enzymolytic (EPF) should have a greater growth performance than broilers. Two trials were conducted evaluate effects or EPF supplementation on performance, serum biochemical indices, meat quality, cecal short-chain fatty acids, microbiota, metabolites...
Repeated and independent emergence of trait divergence that matches habitat differences is a sign parallel evolution by natural selection. Yet, the molecular underpinnings are targeted adaptive often remain elusive. We investigate this question combining genome-wide analyses copy number variants (CNVs), single nucleotide polymorphisms (SNPs), gene expression across four pairs lake river populations three-spined stickleback (Gasterosteus aculeatus). tested whether CNVs span entire genes SNPs...
Nucleophosmin/B23, an abundant nucleolar protein, plays multiple roles in cell growth and proliferation, yet, little has been studied about its function regulating dynamics of microtubules. Here, we report that B23 directly interacts with Eg5, a member the kinesin family, cytosol. The DNA/RNA binding domain motor Eg5 were found to be involved their interaction. Both vivo vitro evidences showed acts as upstream regulator promoting microtubule polymerization. Moreover, further demonstrated...
Although equal sex ratio is ubiquitous and represents an equilibrium in evolutionary theory, biased ratios are predicted for certain local conditions. Cases of bias have been mostly reported single species, but little known about its evolution above the species level. Here, we surveyed progeny 23 nematode genus Caenorhabditis, including 19 which tested multiple strains. For with strains, five had female-biased two non-biased all respectively. The other 12 showed polymorphic across...
// Tianwei Zhang 1 , Lei Lv Yun Huang Xiaohui Ren Qinghua Shi 1, 2 Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity Chronic Diseases, Hefei National for Physical Sciences at Microscale, School Life Sciences, Center Excellence in Science, University Science Technology China, 230027, Anhui, China Collaborative Innovation Development, Shanghai 200438, Correspondence to: Shi, email: qshi@ustc.edu.cn Keywords: asbestos, aneuploidy, binucleated cell, tetraploid,...
OBJECTIVE To explore the prognostic risk factors of bloodstream infection (BSI) in intensive care unit (ICU) patients, furthermore, to provide a reliable evidence for early warning and treatment critical patients with BSI. METHODS A retrospective study was performed. The clinical data blood culture-positive admitted ICU Affiliated Hospital Guizhou Medical University from January 1 September 30, 2019 were analyzed. including gender, age, proportion basic diseases, acute physiology chronic...
Abstract Although equal sex ratio is ubiquitous and represents an equilibrium in evolutionary theory, biased ratios are predicted for certain local conditions. Cases of bias have been mostly reported single species, but little known about its evolution above the species level. Here, we surveyed progeny 23 nematode genus Caenorhabditis , including 19 which tested multiple strains. For with strains, 5 had female-biased 2 non-biased all respectively. The other 12 showed polymorphic across...