A5050615418- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Hemoglobinopathies and Related Disorders
- Digital Imaging for Blood Diseases
- Histone Deacetylase Inhibitors Research
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- 14-3-3 protein interactions
- Extracellular vesicles in disease
- Tumors and Oncological Cases
- Hepatocellular Carcinoma Treatment and Prognosis
- Neonatal Respiratory Health Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- HIV/AIDS drug development and treatment
Semmelweis University
2012-2024
University of Veterinary Medicine
2016-2019
Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant in adults. Several gene mutations such as NPM1 (nucleophosmin 1) are involved pathogenesis progression AML. The aim this study was to identify genes whose expression associated with driver survival outcome. Genotype data (somatic mutations) including RNA-seq, microarray, qPCR were used for analysis. Multiple datasets utilized training sets (GSE6891, TCGA, GSE1159). A new clinical...
Sarcoidosis is a devastating inflammatory disease affecting many organs, especially the lungs and lymph nodes. Bone marrow-derived mesenchymal stromal cells (MSCs) can "reprogram" various types of macrophages towards an anti-inflammatory phenotype. We wanted to determine whether alveolar from sarcoidosis subjects behave similarly by mounting response when co-cultured with MSCs. Fifteen eight control underwent bronchoscopy bronchoalveolar lavage (BAL). Unselected BAL (70-94% macrophages) were...
Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence risk developing multiple myeloma (MM). During maturation, several programmed genetic rearrangements occur increase variation immunoglobulin chains. Class switch recombination (CSR) is one most important among these mechanisms. Germline polymorphisms altering even subtly this play a role etiology and outcome MM. We performed an association study 30 key CSR genes,...
Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with production monoclonal immunoglobulin (M protein) which can be detected in blood and/or urine. lines evidence suggest that genetic factors are involved MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) susceptibility to disease. SNPs within miRNA-binding sites target genes (miRSNPs) may alter strength miRNA-mRNA interactions, thus deregulating...
Purpose. Dysfunction of matriptase-2 can be involved in iron regulatory disorder via downregulation hepcidin expression. In the present study, we investigated effects 3-amidinophenylalanine-derived matriptase inhibitors on porcine hepatic inflammatory cell models. Methods. Hepatocyte-Kupffer cocultures (ratio 2 : 1 and 6 1) were treated with four structurally related at 50 μM. Cell cytotoxicity relative expressions IL-6 IL-8 levels determined by MTS porcine-specific ELISA. The extracellular...
Adoptive transfer of cultured BMSCs was shown to be immune-suppressive in various inflammatory settings. Many factors play a role the process, but no master regulator BMSC-driven immunomodulation identified. Consequently, an assay that might predict BMSC product efficacy is still unavailable. Below, we show donor variability can monitored by IL-10 production monocytes/macrophages using THP-1 cells (immortalized monocytic leukemia cells) co-cultured with BMSCs. Using mixed lymphocyte reaction...
We evaluated the association between germline genetic variants located within 3'-untranlsated region (polymorphic 3'UTR, ie, p3UTR) of candidate genes involved in multiple myeloma (MM). performed a case-control study International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting 3056 MM patients and 1960 controls recruited from eight countries. selected p3UTR six known to act different pathways relevant pathogenesis, namely KRAS (rs12587 rs7973623), VEGFA (rs10434), SPP1...
Abstract Matriptase-2 (MT-2) is a type II transmembrane serine protease and predominantly attached to the surface of hepatocytes. MT-2 decreases production hepcidin, key regulator iron homeostasis. In this study, effects four 3-amidinophenylalanine-derived combined matriptase-1/matriptase-2 (MT-1/2) inhibitors (MI-432, MI-441, MI-460, MI-461) on hepcidin were investigated in hepatocyte mono- hepatocyte-Kupffer cell co-cultures. MI-461-treated cultures, extracellular hydrogen peroxide...
Bevezetés: A myeloma multiplex túlélése sokat javult az utóbbi két évtizedben, ami elsősorban új kezelési lehetőségek megjelenésének tudható be. Ám a mindennapi életben tapasztaltak sokszor eltérhetnek klinikai vizsgálatok eredményeitől, ezért fontos „real world” adatok összegyűjtése is. Célkitűzés és módszer: Semmelweis Egyetem Belgyógyászati Hematológiai Klinikáján (illetve elődjében, III. Sz. Klinikán) 2008 2021 között diagnosztizált összes myelomás beteg túlélési adatait elemeztük....
Abstract: Diffuse large B-cell lymphoma (DLBCL), a high-grade lymphoproliferative disease, is the most common in adults, representing 31% of non-Hodgkin lymphomas (NHL). In elderly patients treatment problematic because high toxicity standard chemotherapy protocols, especially relapsed cases, where high-dose and haematopoietic stem cell transplantation would be best choice. More more data becoming available on alternative refractory/relapsed NHL, including studies positive effect thalidomide...
Absztrakt: Az akut myeloid leukémia (AML) osztályozásának és rizikóbecslésének alapjául a citogenetikai eltérések szolgálnak, azonban az elmúlt években új generációs szekvenálásnak (NGS) köszönhetően nagy előrelépések történtek AML genomszintű feltérképezésében. újonnan megismert genetikai diagnosztikus prognosztikus jelentőséggel bírnak, így mára nemzetközi ajánlásokba is felvételre kerültek. kezelése terén évtizedekben nem következett be jelentős változás, visszatérő génmutációk...
Absztrakt: A nemszteroid gyulladáscsökkentők (NSAID-ok) lokális és szisztémás formában történő alkalmazása egyre elterjedtebbé vált, az ezzel kapcsolatos adverz reakciók gyakoriak. szerzők egy 49 éves férfi beteg esetét ismertetik, aki lábszárak fájdalma miatt etofenamáttartalmú készítményt alkalmazott, majd alkalmazás helyén, UV-expozíciót követően, haemorrhagiás, atípusos, kontaktdermatitisnek megfelelő bőrtünetek jelentek meg. Tüneteinek rapid terjedése sürgősségi fekvőbeteg-ellátásra...
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Response to treatment in multiple myeloma (MM) is routinely measured by serum urine M-protein free light chain (FLC), as described the International Working Group (IMWG) consensus statement. A non-negligible subgroup of patients however present without measurable biomarkers, others become oligo- or non-secretory during recurrent relapses. Aims: The aim our research was evaluate soluble B-cell maturation antigen...
Acute myeloid leukemia (AML) is a hematological malignancy with high mortality rate. The treatment especially challenging in patients older than 65 years, which the large majority of those. For unfit for intensive chemotherapy regimens, only palliative cytoreduction and basic supportive care used to be options our unit. However, from 2018, azacitidine-venetoclax combination has been new therapeutic alternative. This resulted marked survival benefit clinical trials, however, its impact on...