A5100452221- Climate change and permafrost
- Cryospheric studies and observations
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Diverse Approaches in Healthcare and Education Studies
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Bone health and treatments
- Education, Safety, and Science Studies
- Dermatology and Skin Diseases
- Liver Disease Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Radiomics and Machine Learning in Medical Imaging
- Allergic Rhinitis and Sensitization
- Genomics and Rare Diseases
- Lower Extremity Biomechanics and Pathologies
- Parvovirus B19 Infection Studies
- Hip disorders and treatments
- Sports Performance and Training
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Phytochemicals and Antioxidant Activities
- Genetic factors in colorectal cancer
- Ultrasound Imaging and Elastography
Kyung Hee University
2009-2025
Korea Research Institute of Bioscience and Biotechnology
2025
Kyungpook National University
2007-2024
Armed Forces Capital Hospital
2022-2024
CHA Bundang Medical Center
2024
CHA University
2024
Konkuk University
2024
University of Michigan
2024
Sejong University
2022
Asan Medical Center
2019-2021
Background Ambroxol (ABX) has been suggested as an augmentative pharmacological agent for neuronopathic Gaucher disease (nGD). This study assessed the long-term safety and efficacy of combined therapy with high-dose ABX enzyme replacement (ERT) in nGD. Methods ABX+ERT was administered 4.5 years four patients initiated at a dose 1.5 mg/kg/day, escalated up to 27 mg/kg/day. The target plasma level 10 µmol/L or less. changes glucocerebrosidase activity, biochemical, neurocognitive findings were...
Aim The underlying mechanism of non‐obese non‐alcoholic fatty liver disease (NAFLD) has not been fully elucidated. We classified patients with NAFLD by sex and body mass index compared their clinical features to clarify the background pathophysiology NAFLD. Methods A total 404 were divided according (<25 [non‐obese], 25 <30 [obese], ≥30 [severe obese]), further 253 without obesity (non‐NAFLD). Results proportion individuals was 25.7% in men 27.6% women. male female groups had lower...
Nitric oxide (NO) plays an important role in anoxic preconditioning to protect the heart against ischemia-reperfusion injuries. The present work was performed study better NO-cGMP-protein kinase G (PKG) signaling pathway activation of both sarcolemmal and mitochondrial ATP-sensitive K+ (KATP) channels during (APC) final influence on reducing anoxia-reperfusion (A/R)-induced cardiac damage rat hearts. upstream regulating elements controlling NO-cGMP-PKG signal-induced KATP channel opening...
Mycobacterium abscessus is the one of most feared bacterial respiratory pathogens in world. Unfortunately, there are many problems with current M. therapies available. These include misdiagnoses, high drug resistance, poor long-term treatment outcomes, and costs. Until now, have only been a few new compounds or formulations which active against abscessus, these present preclinical clinical development only. With that mind, more powerful anti-M. medicines need to be discovered developed. In...
Atopic dermatitis (AD) is a common disease in children, and epicutaneous treatment with chemical hapten such as 2,4-dinitrofluorobenzene (DNFB) evokes an AD-like reaction NC/Nga mice under specific pathogen-free conditions. Melatonin (N-acetyl-5-methoxytryptamine) synthesized by the pineal gland, has several different physiologic functions, which include seasonal reproduction control, immune system modulation, free radical scavenging, inflammatory suppression. In present study, we...
Cigarette smoke (CS) causes harmful alterations in the lungs and airway structures functions that characterize chronic obstructive pulmonary disease (COPD). In addition to COPD, active cigarette smoking other respiratory diseases diminishes health status. Furthermore, recent studies show that, α, β-unsaturated aldehyde acrolein CS induces production of interleukin (IL)-8, which is known be related bronchitis, rhinitis, fibrosis, asthma. addition, lung fibroblasts secrete IL-8, has a...
Although sphingosine 1-phosphate (S1P) plays diverse roles in bone metabolism, the most prominent role seems to be augmentation of resorption. The objective study was investigate possibility using S1P as a predictor for osteoporotic vertebral fracture (VF) risk. This case-control conducted clinical unit Korea. Sixty-nine cases having radiological VF and 69 age- body mass index-matched controls among 460 eligible postmenopausal women participated study. Lateral thoracolumbar radiographs,...
To determine the mechanism of action effects phytoalexins in soybeans, we analyzed α-glucosidase inhibition kinetics using Michaelis-Menten plots and Lineweaver-Burk plots. The results showed that type with glyceollin was competitive, genistein noncompetitive, daidzein uncompetitive, luteolin a mixed mode action. Ki values were determined Dixon plot as glyceollin, 18.99 μM; genistein, 15.42 luteolin, 16.81 daidzein, 9.99 μM. Furthermore, potential synergistic between three polyphenols...
Abstract Sarcopenia is a pathological condition affecting the development and progression of NAFLD. Urinary levels titin-N fragment, biomarker reflecting muscle damage, were measured in NAFLD subjects, analyzed retrospective manner for possible correlations with pathophysiology to assess their clinical relevance. This study enrolled 153 subjects 100 without NAFLD, obesity or diabetes mellitus (non-NAFLD). had more decreased knee extension strength. greater subcutaneous fat thickness echo...
Abstract Air temperature (Ta), snow depth (Sd), and soil (Tg) are crucial variables for studying the above- below-ground thermal conditions, especially in high latitudes. However, in-situ observations frequently sparse inconsistent across various datasets, with a significant amount of missing data. This study has assembled comprehensive dataset Ta, Sd, Tg Northern Hemisphere (higher than 30°N latitude), spanning 1960–2021. encompasses metadata daily data time series 27,768, 32,417, 659 gages...
Heredity is an important risk factor for osteoporotic fracture, but it remains unclear whether genetic factors improve the predictability of future fracture occurrence. To compare integration model profiling with current predicting A retrospective observational cohort study. Postmenopausal women aged 45–93 years who were untreated (n = 117), hormone-treated 491), or bisphosphonate (BP)-treated 415), a mean 6.1-year follow-up. The main outcome was incident fractures. Ninety-five single...
ABSTRACT Clinical risk factors (CRFs), with or without bone mineral density (BMD), are used to determine the of osteoporotic fracture (OF), which has a heritable component. In this study we investigated whether genetic profiling can additionally improve ability predict OF. Using 1229 unrelated Korean postmenopausal women, 39 single-nucleotide polymorphisms (SNPs) in 30 human genomic loci were tested for association osteoporosis-related traits, such as BMD, osteoporosis, vertebral (VF),...
Family support can help older adults better adhere to exercise routine, but it remains unclear whether an program targeting married couples would have stronger effects on adherence than a for individuals. The purpose of this study was determine the over 24-week follow-up period. Thirty-four and 59 participated in as couple non-couple groups (CG NCG, respectively). All participants attended 8-week supervised (once week home-based comprising walking strength exercises) then measurement (24...
To evaluate the precipitating factors and symptoms of primary spontaneous pneumomediastinum (PSPM) to assess related with recurrent (RSPM).From 2010 2021, 237 PSPM patients were included in this retrospective study. Clinical information including in-hospital periods, morbidity, mortality, presenting symptoms, events, smoking, asthma history was obtained. The smoking subdivided into "ex-smoker" or "current smoker". severity categorized "mild intermittent", persistent", "moderate "severe...
It is known that steroid usage and alcohol abuse are major etiological factors in the development of avascular necrosis (AVN), a bone disease produces osteonecrosis femoral head. The facilitation fat biosynthesis by steroids disrupts blood supply into SREBP-2 plays central role maintenance lipid homeostasis through stimulating expression genes associated with cholesterol biosynthetic pathways. aim this study was to examine association between polymorphisms gene AVN susceptibility Korean...
Some studies have suggested that coagulation disorders may be implicated in osteonecrosis of the femoral head (ONFH). The C677T polymorphism 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene has been postulated to a genetic risk factor for venous thromboembolism and Caucasians, but this relationship not established other populations. In study, we conducted case-control analysis whether MTHFR polymorphisms are associated with ONFH Korean patients. Fifteen single nucleotide (SNPs) were...