A5101833711- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Heme Oxygenase-1 and Carbon Monoxide
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Endoplasmic Reticulum Stress and Disease
- Paraoxonase enzyme and polymorphisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Hippo pathway signaling and YAP/TAZ
- Cholesterol and Lipid Metabolism
- Ubiquitin and proteasome pathways
- Chemokine receptors and signaling
- Adipose Tissue and Metabolism
- Calcium signaling and nucleotide metabolism
- Phagocytosis and Immune Regulation
- Wnt/β-catenin signaling in development and cancer
Vanderbilt University
2020-2024
Southwest University
2022
Northeastern University
2022
Jiangnan University
2018-2019
The phenotypic transformation from differentiated to dedifferentiated vascular smooth muscle cells (VSMCs) plays a crucial role in VSMC proliferation and remodeling many cardiovascular diseases including hypertension. Nesfatin-1, multifunctional adipocytokine, is critically involved the regulation of blood pressure. However, it still largely unexplored whether nesfatin-1 potential candidate switch Experiments were carried out Wistar-Kyoto rats (WKY), spontaneously hypertensive (SHR), human...
Salusin-β is abundantly expressed in many organs and tissues including heart, blood vessels, brain kidneys. Recent studies have identified salusin-β as a bioactive peptide that contributes to various diseases, such atherosclerosis, hypertension, diabetes metabolic syndrome. However, the role of pathogenesis acute kidney injury (AKI) largely unclear. In present study, we investigated roles cisplatin or lipopolysaccharide (LPS)-induced renal injury. Herein, found expression was upregulated...
Studies in zebrafish identify a conserved axis that mediates metabolic stress–induced pancreatic islet inflammation.
Abstract Glucagon has emerged as a key regulator of extracellular amino acid (AA) homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which drives adaptive proliferation glucagon-producing α cells. Aside from mammalian target rapamycin complex 1 (mTORC1), the role other AA sensors cell not been described. Here, using both genders mouse islets and receptor ( gcgr )-deficient zebrafish Danio rerio ), we show requires activation signal-regulated protein kinase (ERK1/2)...
Persistent endoplasmic reticulum (ER) stress induces islet inflammation and β cell loss. How contributes to loss remains uncertain. We have reported previously that chronic overnutrition-induced ER in cells causes Ripk3-mediated inflammation, macrophage recruitment, a reduction of numbers zebrafish model. show here results from the intricate communications among cells, macrophages, neutrophils. Macrophage-derived Tnfa cxcl8a cells. Cxcl8a, turn, attracts neutrophils macrophage-contacted...
B-cell receptor-associated protein 31 (BAP31) has been shown to overexpress in a wide range type of cancers. The present study aims investigate the role BAP31 on migration lung cancer. Results showed that knockdown cells was weaken than control cells. Applying TGFβ treat could reduce cell migration. enhancement proliferation by treatment downregulated after knockdown. death and G0/G1 phase arrest increased with siRNA when compared alone. Gene expression analysis Bax/Bcl2, MLKL LC3...
Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated secretion (GSIS) has been extensively studied, much less is known about basal secretion. Here, we performed a genome-wide CRISPR/Cas9 knockout screen identify novel regulators of
Abstract Glucagon has emerged as the main regulator of extracellular amino acid homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which drives adaptive proliferation glucagon-producing α cells. Aside from mammalian target rapamycin complex 1 (mTORC1), role other sensors cell not been described. Here, using gcgr -deficient zebrafish and cultured mouse islets, we show that requires calcium sensing receptor (CaSR) downstream signalregulated protein kinase (ERK1/2)....
Persistent ER stress induces islet inflammation and loss of β cells. How contributes to cell remains uncertain. We have previously reported that chronic overnutrition-induced in cells causes Ripk3-mediated inflammation, macrophage recruitment, a zebrafish model. show here results from the intricate communications among cells, macrophages neutrophils. Macrophage-derived Tnfa cxcl8a Cxcl8a turn attracts neutrophils contacted “hot spots” where occurs. also potentiation chemokine expression...
Over the last ten years, researchers suggested a critical role for brain reward system in stress resilience. However, no study has provided an empirical link between activity mesostriatal regions during and recovery of cortisol responses. Moreover, although sensitivity as trait been demonstrated to promote resilience, whether it modulates resilience how this effect could be achieved by inherent neuroendocrine remain elusive. To end, seventy young adults participated ScanStress task while...