A5069073554- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Prenatal Screening and Diagnostics
- Marine and coastal ecosystems
- Plant biochemistry and biosynthesis
- Gene Regulatory Network Analysis
- Traditional Chinese Medicine Analysis
- Infective Endocarditis Diagnosis and Management
- Genetic diversity and population structure
- Parvovirus B19 Infection Studies
- Bacterial Infections and Vaccines
- Genetic Mapping and Diversity in Plants and Animals
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Blood properties and coagulation
- Kawasaki Disease and Coronary Complications
- Heavy metals in environment
- Thermal Radiation and Cooling Technologies
- Single-cell and spatial transcriptomics
- Urban Heat Island Mitigation
- Marine Biology and Ecology Research
- Fungal and yeast genetics research
- Peptidase Inhibition and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
Beijing Children’s Hospital
2018-2025
Capital Medical University
2003-2025
Southern University of Science and Technology
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Advanced Research Institute
2025
Linyi University
2024
Second Xiangya Hospital of Central South University
2024
Guangxi Medical University
2024
Central South University
2024
Shenzhen Maternity and Child Healthcare Hospital
2022-2023
Mechanochromic light control technology that can dynamically regulate solar irradiation is recognized as one of the leading candidates for energy-saving windows. However, lack spectrally selective modulation ability still hinders its application different scenarios or individual needs. Here, inspired by generation structure color and change living organisms, a simple layer-by-layer assembly approach toward large-area fabricating mechanically responsive film visible near-infrared...
There is currently no research on the diagnostic value of metagenomic next-generation sequencing (mNGS) for a single pathogens in CSF. The aim this study was to analyse mNGS identifying Streptococcus pneumoniae (S. pneumoniae) paediatric bacterial meningitis.Bacterial meningitis (BM) cases from October 23, 2014, December 31, 2016, and 1, 2017, July 2018 at Beijing Children's Hospital were reviewed. Clinical features analysed.We diagnosed 135 patients with BM study. A total 43 S. identified...
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression cardiovascular diseases (CVD). Its predictive value for all-cause and mortality CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 from National Health Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, restricted cubic spline (RCS) analyses were used to assess relationship between NLR risk....
Abstract In mid‐May, 2019, the fall armyworm (FAW) Spodoptera frugiperda invaded Jiangxi Province, China, and caused extensive damage to corn crops. However, little attention has been given life‐history traits of FAW. present study, we systematically investigated newly invasive FAW on leaves at 19, 22, 25, 28, 31°C under a photoperiod LD 15:9 hr. The thrived with short developmental periods, high survival rates larvae pupae, very mating success rates, fecundity. pupal stage was significantly...
Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, role DKK1 in progression non small cell lung cancer (NSCLC) not fully understood. In this study, RT-PCR and Western blot were used to examine expression a panel ten human NSCLC lines tissues. was highly transactivated great majority these lines. The upregulated on both mRNA protein levels tissues compared with adjacent normal Immunohistochemistry immunofluoresence revealed that mainly distributed cytoplasm...
Quantitative variation of floral organs in plants is caused by an extremely complex process transcriptional regulation. Despite progress model plants, the molecular mechanisms quantitative remain unknown woody flower plants. The Paeonia rockii originated China a precious plant with ornamental, medicinal and oil properties. There wide number carpel P. rockii, but mechanism has rarely been studied. Then comparative transcriptome was performed among two cultivars different development patterns...
Abstract Radiative cooling has emerged as a promising technique for reducing energy consumption in building thermal management due to its passive property and no external requirement. Despite significant advances, scalable production of artificial photonic radiators with periodic structures, environmental stability, high radiative performance, economic applicability is still challenging most state‐of‐the‐art coolers. Rational structure materials design are essential promote daytime sunlight...
High sensitivity and spatial recognition of pressure sensors are important for application the in electronic skins, situ visualization is a practical effective approach to identifying information. Here, we present facial strategy achieve information that visible naked eye coloring form by designing an H3PO4/PVA film with hemispheric microstructures integrated electrochromic sensor. The device can be applied different stress scenarios within range 0-250 kPa adjusting spacing identify...
Pneumococcal meningitis is a central nervous system infection responsible for high rates of mortality and long-term disability worldwide. We aimed to summarise the clinical characteristics, as well determine risk factors progression paediatric pneumococcal (PM). This retrospective study included children with microbiologically confirmed PM who were admitted Beijing Children's Hospital between 2012 2021. The laboratory examination results characteristics enrolled patients analysed. All...
Abstract Motivation: Recent advances in high-throughput experimental techniques have yielded a large amount of data on protein–protein interactions (PPIs). Since these can be organized into networks, and since separate PPI networks constructed for different species, natural research direction is the comparative analysis such across species order to detect conserved functional modules. This task network alignment. Results: Most conventional alignment algorithms adopt node-then-edge-alignment...
Quercus variabilis is a tree species of ecological and economic value that widely distributed in China. To effectively evaluate, use, conserve resources, we applied 25 pairs simple sequence repeat (SSR) primers to study its genetic diversity structure 19 natural forest or secondary populations Q. (a total 879 samples). A 277 alleles were detected. Overall, the average expected heterozygosity (He) was 0.707 allelic richness (AR) 7.79. manifested loss heterozygosity, mean inbreeding...
Wolfberry (Lycium Linn. 2n = 24) fruit, Gouqizi, is a perennial shrub, traditional food and medicinal plant resource in China. Leaf fruit related characteristics are economically important traits that the focus for genetic improvement, but few studies into molecular genetics of this crop have been reported to date. Here, an F1 population (302 individuals) derived from cross between "NO.1 Ningqi" barbarum L.) "Chinese gouqi" chinese Mill.) was constructed. We recorded weight, longitude,...
Dinoflagellates are a group of unicellular organisms that major component aquatic eukaryotes and important contributors to marine primary production. Nevertheless, many dinoflagellates considered harmful algal bloom (HAB) species due their detrimental environmental human health impacts. Cyst formation is widely perceived as an adaptive strategy cyst-forming in response adverse conditions. Dinoflagellate cysts play critical roles dynamics. However, our insight into the underlying molecular...
The lollipop-diagram is one of the widely used graphical representations to visualize and explore translational effects genetic mutations in cancer genomics. However, an easy-to-use tool with full functionality still lacking. Here, we introduce g3viz, R package that enables researchers mutation data using a web browser. With few lines code, users can interactively details, annotate findings export resultant diagrams high-quality figures. Because usefulness usability, g3viz be generally...
Research Highlights: This study, based on the first collection of cultivated Paeonia rockii (flare tree peony, FTP) germplasm across main distribution area by our breeding desires, comprehensively evaluates these accessions using phenotypic traits, expressed sequence tag (EST)-simple repeat (SSR) markers and chloroplast DNA sequences (cpDNA). The results show that collected selectively us can represent genetic background information FTP as a crops. Background Objectives: has high cultural,...
GenoLab M is a recently developed next-generation sequencing (NGS) platform from GeneMind Biosciences. To establish the performance of M, we present first report to benchmark and compare WGS WES data sequencer NovaSeq 6000 NextSeq 550 in various types analysis. For WGS, thirty-fold Illumina processed by GATK pipeline currently considered as golden standard. Thus this dataset generated reference study.GenoLab showed an average 94.62% Q20 percentage for base quality, while was slightly higher...
Due to cell-to-cell variability and asymmetric cell division, cells in a synchronized population lose synchrony over time. As result, time-series measurements from populations do not reflect the underlying dynamics of cell-cycle processes. Here, we present branching process deconvolution algorithm that learns more accurate view dynamic processes, free convolution effects associated with imperfect synchronization. Through wavelet-basis regularization, our method sharpens signal without...