A5081491650- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Hepatocellular Carcinoma Treatment and Prognosis
- Photoacoustic and Ultrasonic Imaging
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Ultrasonics and Acoustic Wave Propagation
- Ectopic Pregnancy Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Assisted Reproductive Technology and Twin Pregnancy
- Pancreatic and Hepatic Oncology Research
- Cerebrovascular and Carotid Artery Diseases
- Transplantation: Methods and Outcomes
- Microbial Inactivation Methods
- Organ Transplantation Techniques and Outcomes
- Glioma Diagnosis and Treatment
- Liver Disease and Transplantation
- Ultrasound in Clinical Applications
- Infrared Thermography in Medicine
- Prenatal Screening and Diagnostics
- Cerebrospinal fluid and hydrocephalus
- Renal and Vascular Pathologies
- Dermatologic Treatments and Research
- Maternal and fetal healthcare
Inserm
2015-2024
Centre Léon Bérard
2009-2024
Université Claude Bernard Lyon 1
2015-2024
Laboratoire des applications Thérapeutiques des Ultrasons
2015-2024
Cancéropôle Lyon Auvergne-Rhône-Alpes
2016
Lyon College
2016
Committee on Publication Ethics
2016
Institute of Cancer Research
2006-2010
CHU Dijon Bourgogne
2007-2008
Royal Marsden NHS Foundation Trust
2006-2007
Background Surgery is the only curative treatment in patients with colorectal liver metastases (CLM), but 10–20% of are eligible. High Intensity Focused Ultrasound (HIFU) technology proven value several indications, notably prostate cancer. Its intra-operative use CLM has not previously been studied. Preclinical work suggested safety and feasibility a new HIFU device capable ablating volumes up to 2cm x few seconds. Methods We conducted prospective, single-centre phase I-IIa trial. was...
Thermal ablation by physical agents is widely used in clinical settings, but it generally results a small coagulated volume. Here, we report that technologically advanced high intensity focused ultrasound transducer can significantly enlarge the volume over short periods of time. Eight emitters were created sectioning single toric piezocomposite transducer. A thermal lesion when eight perform alternative and consecutive 5s exposures. This paper presents vivo evidence obtained from 40s total...
In the liver, efficacy of radiofrequency or high-intensity focused ultrasound (HIFU) ablation is impaired by blood perfusion. This can be overcome hepatic inflow occlusion. Here we report in vivo evaluation ablations performed liver using a surgical toroidal HIFU device used during an open procedure with and without The was composed 256 toroidal-shaped emitters working at 3 MHz integrated imaging probe 7.5 MHz. Using intermittent Pringle maneuver (IPM), thermal were created three pigs...
A toroidal high-intensity focused ultrasound (HIFU) transducer was used to expose normal bladder wall tissues non-invasively in vivo a porcine model order investigate the potential treat tumors. The divided into 32 concentric rings with equal surface areas, operating at 2.5 MHz. Eight animals were split two groups of 4. In first group, post-mortem evaluation performed immediately after exposure. second survived for up seven days before evaluation. imaging guided HIFU device hand-held during...
To demonstrate in a porcine model that high-intensity focused ultrasound (HIFU) with toroid-shaped emitters may have role treating unresectable colorectal liver metastases.Surgical resection is the only curative option for hepatic metastases. Only 20% of patients are suitable surgery. Many ablative techniques been assessed but several limitations documented: traumatic puncture parenchyma, limited size lesions, and inability to monitor treatment real time.A HIFU device 256 integrated imaging...
The use of hand-held ultrasound strain imaging for the intra-operative real-time visualization HIFU (high-intensity focused ultrasound) ablations produced in liver by a toroidal transducer was investigated. A linear 12 MHz probe used to obtain radiofrequency signals. Using fast cross-correlation algorithm, images were calculated and displayed at 60 frames s−1, allowing intra-operatively. Fourteen lesions four pigs. Intra-operative feasible owing high frame rate. correlation between...
Abstract New curative and palliative treatments are needed to respond the poor prognosis of esophageal cancer. The purpose this study was determine whether magnetic resonance imaging (MRI) MR thermometry can be used monitor thermal ablation induced by an intraluminal high‐intensity ultrasound applicator positioned in esophagus. Experiments were performed vivo 2 pig esophagi (25 lesions per pig). Respiratory gated or cardiac with segmented echo‐planar gradient echo sequences. All acquisitions...
This work was undertaken to investigate the feasibility of using a cylindrical phased array for transoesophaeal thermal ablation under magnetic resonance (MR) imaging guidance. Sixty-four transducers (0.45 mm wide by 15 tall), operating at 4.6 MHz, were spread around periphery 10.6-mm-diam cylinder. The head applicator covered with 65-microm thick latex balloon attached watertight seals. envelope inflated degassed water provide acoustic coupling between transducer and tissues. underlying...
Esophageal tumors generally bear a poor prognosis. Radical surgery is the only curative method available but not feasible in majority of patients; palliative therapy with stent placement performed. It has been demonstrated that High Intensity Ultrasound can induce rapid, complete and well-defined coagulation necrosis. Thus, for treatment esophageal tumors, we have designed an ultrasound applicator uses intraluminal approach to fill up this therapeutic gap. Thermal ablation performed...
Purpose: Bleeding is the main cause of postoperative complications during hepatic surgery. Blood loss and transfusions increase tumor recurrence in liver metastases from colorectal cancer. A high intensity focused ultrasound (HIFU) device with an integrated imaging probe was developed for treatment metastasis. Methods: The HIFU toroidal‐shaped transducer contains 256 elements (working frequency: 3 MHz) can create a single conical lesion 40 s. Then, volume be significantly increased by...
To demonstrate in an ex-vivo model the feasibility of applying high-intensity focused ultrasound (HIFU) using a toroidal transducer for creation placental lesions.In this study we used transducer, composed 32 ring-shaped emitters with probe at center, operating frequency 2.5 MHz. We examined 45 human placentae, following either normal vaginal delivery or medical termination pregnancy between 17 and 40 gestational weeks. First, attenuation coefficients 12 placentae were measured integrated...
High intensity ultrasound has shown considerable ability to produce precise and deep thermal coagulation necrosis. Focused, cylindrical, spherical or plane transducers have been used induce high temperatures in tissues coagulate proteins kill cells. Recently magnetic resonance imaging (MRI) used, with extracorporeal intracavitary focused cylindrical interstitial applicators, monitor temperature distribution provide feedback during heating procedures. If intraluminal applicators are the...