A5074123573- Single-cell and spatial transcriptomics
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Immune cells in cancer
- Urological Disorders and Treatments
- Extracellular vesicles in disease
- Zebrafish Biomedical Research Applications
- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- ATP Synthase and ATPases Research
- Bacterial Identification and Susceptibility Testing
- Pain Mechanisms and Treatments
- Parasite Biology and Host Interactions
- Medicinal Plants and Bioactive Compounds
- Immune responses and vaccinations
- Cancer-related molecular mechanisms research
- Nicotinic Acetylcholine Receptors Study
- Nosocomial Infections in ICU
- Gastrointestinal motility and disorders
- Myofascial pain diagnosis and treatment
- Scoliosis diagnosis and treatment
- Axon Guidance and Neuronal Signaling
- Neuroscience of respiration and sleep
Peking University
2023-2025
Beijing Academy of Artificial Intelligence
2025
Hainan General Hospital
2023-2025
General Hospital of Shenyang Military Region
2022-2025
Ruijin Hospital
2016-2024
Shanghai Jiao Tong University
2023-2024
Fuzhou University
2022-2024
Shanghai Institute of Nutrition and Health
2023
University of Chinese Academy of Sciences
2023
Hainan Medical College Hospital
2023
The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little known about mechanisms responsible for remodeling in AD pathogenesis. α7 nicotinic acetylcholine receptors (α7nAChR) has been shown to have profound effects on mitochondrial oxidative stress both organ Here, we investigate the role α7nAChR mediating amyloid-β (Aβ) cultured mouse cardiomyocytes (HL-1 cells) model mice (APP/PS1). In vitro,...
Bougainvillea L. (Nyctaginaceae) is a South American native woody flowering shrub of high ornamental, economic, and medicinal value which susceptible to cold damage. We sequenced the complete chloroplast (cp) genome B. glabra spectabilis, two morphologically similar species differing in resistance. Both genomes showed typical quadripartite structure consisting one large single-copy region, small inverted repeat regions. The cp size spectabilis was 154,520 154,542 bp, respectively, with 131...
A total of 417 intangible cultural heritage objects (ICHOs) are intertwined with traditional Chinese art, showcasing China’s rich historical and distinctive creative allure. However, ICHOs currently grapple a significant succession quandary due to modernization endeavors the impacts globalization. Hence, this study scrutinizes spatial distribution ICHO projects inheritors examines methodologies for inheriting these ICHOs, employing approaches such as closest neighbor index, Moran’s I kernel...
Irritable bowel syndrome (IBS) substantially affects quality of life and requires early prevention. This study aimed to elucidate the relationships between IBS daily behaviors, including sedentary behavior (SB), physical activity (PA), sleep. In particular, it seeks identify healthy behaviors reduce risk, which previous studies have rarely addressed. Daily were retrieved from self-reported data on 362,193 eligible UK Biobank participants. Incident cases determined by self-report or health...
The role that sleep patterns play in sepsis risk remains poorly understood. objective was to evaluate the association between various behaviours and incidence of sepsis. In this prospective cohort study, we analysed data from UK Biobank (UKB). A total 409,570 participants who were free at baseline included. We used a composite score considered following five behaviours: chronotype, duration, insomnia, snoring, daytime sleepiness. Cox proportional hazards regression analysis estimate...
The precise molecular mechanisms through which neutrophils regulate macrophages in the progression and resolution of acute inflammation remain poorly understood. Here, we present new findings on role Dicer regulating macrophage phenotypic transitions essential for proper inflammatory resolution, influenced by neutrophils. Using a zymosan A (Zym A)-induced self-limited mouse peritonitis model, observed that expression was significantly reduced neutrophil-derived IFN-γ during phase, but...
Rarely does Pandoraea occur in bloodstream infections (BSI), although it's typically found cystic fibrosis. This study aims to decipher the genetic map and obtain insights of clinical symptoms into from BSI patients. 30 suspected patients' diagnostic records medical histories were recorded. spp. isolates collected subjected antimicrobial susceptibility testing, Sanger sequencing Whole-genome (WGS). Of cases, five (16.67%) ultimately died, whereas 25 (83.33%) are alive. purified showed high...
Intestinal metaplasia of the bladder is an uncommon glandular proliferation. We examined a large series intestinal for clinicopathological features and discuss significance this lesion.All cases diagnosed in our institution between 1990 2014 were retrospectively reviewed. Patients with history urothelial carcinoma or concurrent adenocarcinoma excluded. Patient characteristics, pathological features, follow-up outcomes obtained.We identified 89 patients during period. Sixty seven men 22...
In the aorta-gonad-mesonephros (AGM) region of mouse embryos, pre-hematopoietic stem cells (pre-HSCs) are generated from rare and specialized hemogenic endothelial (HECs) via endothelial-to-hematopoietic transition, followed by maturation into bona fide hematopoietic (HSCs). As HECs also generate a lot progenitors not fated to HSCs, powerful tools that pre-HSC/HSC-specific become urgently critical. Here, using gene knockin strategy, we firstly developed an Hlf-tdTomato reporter model...
Atrial fibrillation (AF) is the most frequent arrythmia managed in clinical practice. Several mechanisms have been proposed to contribute occurrence and persistence of AF, which oxidative stress plays a non-negligible role. The endocannabinoid system (ECS) involved variety physiological pathological processes. Cannabinoid receptor 1 (CB1R) cannabinoid 2 (CB2R) are expressed heart, studies shown that activating CB2R has protective effect on myocardium. However, role AF unknown.Angiotensin II...
Hematopoietic stem cells (HSCs) are derived from hemogenic endothelial (HECs) during embryogenesis. The HSC-primed HECs increased to the peak at embryonic day (E) 10 and have been efficiently captured by marker combination CD41 – CD43 CD45 CD31 + CD201 Kit CD44 (PK44) in aorta-gonad-mesonephros (AGM) region of mouse embryos most recently. In present study, we investigated spatiotemporal functional heterogeneity PK44 around time emergence HSCs. First, E10.0 AGM could be further divided into...
Epidemiological studies have shown a relatively strong association between occupational lower back pain (LBP) and long-term exposure to vibration. However, there is limited knowledge of the impact vibration sedentariness on bone metabolism lumbar vertebra mechanism bone-derived LBP. The aim this study was investigate effects in forced posture (a seated posture) biochemical indices, morphometric mechanical properties vertebra, provide scientific theoretical basis for LBP, serum levels Ca2+,...