Anna Erickson

ORCID: 0000-0003-3937-9217
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About
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Research Areas
  • Blood transfusion and management
  • Erythrocyte Function and Pathophysiology
  • Plant Virus Research Studies
  • Blood groups and transfusion
  • Cancer Cells and Metastasis
  • Hemoglobinopathies and Related Disorders
  • Plant and Fungal Interactions Research
  • TGF-β signaling in diseases
  • Blood donation and transfusion practices
  • Plant Genetic and Mutation Studies
  • Mesenchymal stem cell research
  • Effects of Radiation Exposure
  • Molecular Biology Techniques and Applications
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Cell Adhesion Molecules Research
  • Insect-Plant Interactions and Control
  • Proteoglycans and glycosaminoglycans research
  • Viral gastroenteritis research and epidemiology
  • Genetics and Plant Breeding
  • Acute Ischemic Stroke Management
  • Powdery Mildew Fungal Diseases
  • Plant Disease Resistance and Genetics
  • Hepatitis B Virus Studies
  • Platelet Disorders and Treatments
  • Berry genetics and cultivation research

Cerus (United States)
2013-2025

University of California, Davis
2015-2024

Georgia Institute of Technology
2023

Lawrence Berkeley National Laboratory
2003-2023

Plant (United States)
2015

University of California, Berkeley
2004

American University of Beirut
2003

University of California, San Francisco
2003

University of Alabama at Birmingham
1993-2001

Jobling, M. F., Mott, J. D., Finnegan, T., Jurukovski, V., Erickson, A. C., Walian, P. J., Taylor, S. E., Ledbetter, S., Lawrence, C. M., Rifkin, D. B. and Barcellos-Hoff, H. Isoform-Specific Activation of Latent Transforming Growth Factor β (LTGF-β) by Reactive Oxygen Species. Radiat. Res. 166, 839–848 (2006).The three mammalian transforming growth factor (TGF-β) isoforms are each secreted in a latent complex which TGF-β homodimers non-covalently associated with their respective pro-peptide...

10.1667/rr0695.1 article EN Radiation Research 2006-12-01

Abstract Transforming growth factor β1 (TGFβ) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to promoter neoplastic progression. Ionizing radiation (IR), both carcinogen and therapeutic agent, induces TGFβ activation in vivo. We now show that IR sensitizes human mammary epithelial cells (HMEC) undergo TGFβ-mediated mesenchymal transition (EMT). Nonmalignant HMEC (MCF10A, HMT3522 S1, 184v) were irradiated with 2 Gy shortly after attachment monolayer culture...

10.1158/0008-5472.can-07-1294 article EN Cancer Research 2007-09-15

Abstract Radiation-induced genomic instability, in which the progeny of irradiated cells display a high frequency nonclonal damage, occurs at inconsistent with mutation. We investigated mechanism this nontargeted effect human mammary epithelial (HMEC) exposed to low doses radiation. identified centrosome-associated expression signature HMEC and show here that centrosome deregulation first cell cycle after irradiation, is dose dependent, viable daughters these are genomically unstable as...

10.1158/0008-5472.can-08-1212 article EN Cancer Research 2008-10-15

Ionizing radiation (IR) is a known human breast carcinogen. Although the mutagenic capacity of IR widely acknowledged as basis for its action carcinogen, we and others have shown that can also induce growth factors extracellular matrix remodeling. As consequence, proposed an additional factor contributing to carcinogenesis potential disruption critical constraints are imposed by normal cell interactions. To test this hypothesis, asked whether affected ability nonmalignant mammary epithelial...

10.1073/pnas.1832185100 article EN Proceedings of the National Academy of Sciences 2003-09-05

Background and Objectives Pathogen reduction technology using amustaline (S‐303) was developed to reduce the risk of transfusion‐transmitted infection adverse effects residual leucocytes. In this study, viability red blood cells ( RBC s) prepared with a second‐generation process stored for 35 days evaluated in two different centres. Materials Methods single‐blind, randomized, controlled, two‐period crossover study n = 42 healthy subjects), amustaline‐treated (Test) or Control s were random...

10.1111/vox.12500 article EN cc-by-nc-nd Vox Sanguinis 2017-02-21

BACKGROUND Nucleic acid–targeted pathogen inactivation technology using amustaline (S‐303) and glutathione (GSH) was developed to reduce the risk of transfusion‐transmitted infectious disease transfusion‐associated graft‐versus‐host with red blood cell (RBC) transfusion. STUDY DESIGN AND METHODS A randomized, double‐blind, controlled study performed assess in vitro characteristics amustaline‐treated RBCs (test) compared conventional (control) evaluate safety efficacy transfusion during after...

10.1111/trf.14528 article EN cc-by-nc Transfusion 2018-03-01

Abstract Background Measurement of transfused red blood cell (RBC) survival is relevant to the effective management sickle disease (SCD). Following amustaline/glutathione pathogen‐reduced (PR) RBC transfusion, small quantities PR‐RBC surface‐bound acridine are detectable by flow cytometry. Concurrent biotin labeling was used validate marker and track PR‐RBCs in SCD. Methods SCD patients ( n = 6) on chronic transfusion therapy received three aliquots different (2 μg/mL, 6 18 μg/mL)...

10.1111/trf.18245 article EN cc-by-nc Transfusion 2025-04-18

Over the past decade there has been a growth in development of pathogen reduction technologies to protect blood supply from emerging pathogens. This proven be difficult for red cells (RBCs). However S-303 system shown effectively inactivate broad spectrum pathogens, while maintaining RBC quality.A paired three-arm study was performed compare vitro quality S-303-treated RBCs with stored at room temperature (RT) duration treatment (18-20 hr) and control 2 6°C. Products were sampled weekly over...

10.1111/trf.12545 article EN Transfusion 2014-03-11

Summary Transfusion‐dependent thalassaemia ( TDT ) requires red blood cell concentrates RBCC to prevent complications of anaemia, but carries risk infection. Pathogen reduction offers potential reduce infectious risk. We evaluated the efficacy and safety pathogen‐reduced PR Amustaline‐Glutathione (A‐ GSH for . Patients were randomized a blinded 2‐period crossover treatment sequence six transfusions over 8–10 months with Control A‐ ‐ The outcome utilized non‐inferiority analysis 90% power...

10.1111/bjh.15963 article EN cc-by-nc-nd British Journal of Haematology 2019-05-30

Abstract: τ is a major component of paired helical filaments found in the neurofibrillary tangles Alzheimer's diseased brain. However, mechanism or mechanisms responsible for association to form these aggregates remains unknown. In this study, role intermolecular disulfide bonds formation higher order oligomers bovine and human recombinant isoform T3 was examined using chemical cross‐linking agent disuccinimidylsuberate (DSS). addition, phosphorylation oxidation state on vitro...

10.1046/j.1471-4159.1995.64031209.x article EN Journal of Neurochemistry 1995-03-01

SUMMARY Background and objectives The pathogen inactivation ( PI ) INTERCEPT Blood System for Red Cells utilises amustaline (S‐303) to inactivate a broad range of pathogens in red cell concentrates RCC ). aim this study was investigate the effect on quality treatment with without prion reduction. Methods/materials Five pools five each were prepared. These split treated as follows: (i) stored at 2–6 °C 18 h, (ii) 18–24 (iii) ‐treated, (iv) ‐treated then reduced (v) ‐treated. Prior storage,...

10.1111/tme.12298 article EN Transfusion Medicine 2016-03-23

Since its discovery in 2016, the Polerovirus Barley virus G has been reported at least nine countries and multiple species of monocot plants. All these reports have used PCR and/or sequencing based assays to identify BVG, however none investigated biology BVG. In this study we detail generation first infectious cDNA clone BVG from archived RNA, thereby producing a valuable experimental tool system for studying biology. Using identified two compatible aphid vectors confirmed susceptibility...

10.1016/j.virol.2023.01.011 article EN cc-by Virology 2023-01-19

Abstract Due to their high specificity and efficacy, RNA interference (RNAi)-based strategies have been used for fundamental functional genomics studies in a number of insects. However, its potential translational applications pest management is also great interest. The lack suitable RNAi triggering approaches, however, so far has largely precluded the implementation RNAi-based approaches target aphids. In this work, we first demonstrate that Flock House virus (FHV), an insect virus, can...

10.1007/s10340-022-01499-z article EN cc-by Journal of Pest Science 2022-04-08

Plant virus movement proteins (MPs) facilitate spread in their plant hosts, and some of them are known to target plasmodesmata (PD). However, how the MPs PD is still largely unknown. Carrot mottle (CMoV) encodes ORF3 ORF4 proteins, which involved CMoV movement. In this study, we used as a model study targeting MP. We showed that protein, but not modified led found protein interacts with host cell small ubiquitin-like modifier (SUMO) 1, 2 SUMO-conjugating enzyme SCE1, resulting SUMOylation....

10.1111/nph.17370 article EN publisher-specific-oa New Phytologist 2021-03-28

Mixed infections of a plant infecting polerovirus, umbravirus, and/or tombusvirus-like associated RNAs (tlaRNAs) produce unique virus disease complexes that exemplify “helper-dependence” interactions, type viral synergism occurs when “dependent” lacks genes encoding for certain protein products necessary it to complete its infection cycle can utilize complementary proteins encoded by co-infecting “helper” virus. While much research has focused on polerovirus-umbravirus or polerovirus-tlaRNA...

10.3389/fmicb.2023.1223265 article EN cc-by Frontiers in Microbiology 2023-07-06

Abstract Exoribonuclease-resistant RNAs (xrRNAs) are viral RNA structures that block degradation by cellular 5′-3′ exoribonucleases to produce subgenomic during infection. Initially discovered in flaviviruses, xrRNAs have since been identified wide range of viruses, including those infect plants. High sequence variability among raises questions about the shared molecular features characterize this functional class. Here, we present first structure a plant-virus xrRNA its active...

10.1101/2024.12.17.628992 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-12-20

Plasma thawed and stored at 1 to 6° C for up 5 days (thawed plasma [TP]) provides rapid availability in emergencies reduces waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, viral contamination. We characterized changes amotosalen/ultraviolet A (UVA) light pathogen-reduced, fresh-frozen (FFP) frozen within 24 hours (PF24) with post-thaw storage.Amotosalen/UVA light-treated FFP PF24 were after approximately 3 more than 12 months storage held days....

10.1111/trf.13973 article EN cc-by-nc Transfusion 2017-02-01

Abstract Background Amotosalen/UVA pathogen‐reduced platelet components (PRPCs) with storage up to 7 days are standard of care in France, Switzerland, and Austria. PRPCs provide effective hemostasis reduced risk transfusion‐transmitted infections transfusion‐associated graft versus host disease, wastage improved availability compared 5‐day‐stored PCs. This study evaluated the potency 7‐day by vitro characterization vivo pharmacokinetic analysis autologous Study Design Methods The...

10.1111/trf.17003 article EN cc-by-nc-nd Transfusion 2022-07-09
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