A5101792989- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Resistance in Staphylococcus
- Mosquito-borne diseases and control
- Insect-Plant Interactions and Control
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Insect and Pesticide Research
- Nutritional Studies and Diet
- Molecular Biology Techniques and Applications
- Fatty Acid Research and Health
- Genetic Associations and Epidemiology
- Escherichia coli research studies
- Gene expression and cancer classification
- Bacterial Identification and Susceptibility Testing
- Entomopathogenic Microorganisms in Pest Control
- Heavy Metal Exposure and Toxicity
- Muscle activation and electromyography studies
- Plant and animal studies
- Genetics, Aging, and Longevity in Model Organisms
State Key Laboratory on Integrated Optoelectronics
2025
Chinese Academy of Sciences
2025
Institute of Semiconductors
2025
Shanghai Institute of Nutrition and Health
2022-2024
Cornell University
1993-2024
Institute of Plant Protection
2022-2023
Chinese Academy of Agricultural Sciences
2021-2023
First Affiliated Hospital of Nanchang University
2019-2023
Nanchang University
2019-2023
University of Chinese Academy of Sciences
2022-2023
The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in world. As one of most important crop pests and virus vectors, B. causes substantial losses poses a serious threat to global food security. We report 615-Mb high-quality genome sequence Middle East-Asia Minor 1 (MEAM1), first Aleyrodidae family, which contains 15,664 protein-coding genes. highly divergent from other sequenced hemipteran genomes, sharing no detectable synteny. A number known...
<h3>Context</h3>Precocious amygdala enlargement is commonly observed in young children with autism. However, the age at which abnormal begins and relative growth trajectories of total brain remain unclear.<h3>Objective</h3>To determine whether rate disproportionate to very autism spectrum disorders (ASDs).<h3>Design</h3>Longitudinal structural magnetic resonance imaging study.<h3>Setting</h3>Neuroimaging diagnostic assessments were performed an academic medical center. Participants recruited...
Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a reliable, rapid, and reproducible technique for measuring evaluating changes in gene expression. To facilitate expression studies obtain more accurate RT-qPCR data, normalization relative to stable reference genes required. In this study, profiles of seven candidate genes, including β-actin (Actin), elongation factor 1 α (EF1A), glyceralde hyde-3-phosphate dehydro-genase (GAPDH), cyclophilins A (CypA), vacuolar-type...
Mosquitoes transmit numerous pathogens, but large gaps remain in our understanding of their physiology. To facilitate explorations mosquito biology, we have created Aegypti-Atlas (http://aegyptiatlas.buchonlab.com/), an online resource hosting RNAseq profiles Ae. aegypti body parts (head, thorax, abdomen, gut, Malpighian tubules, ovaries), gut regions (crop, proventriculus, anterior and posterior midgut, hindgut), a time course blood meal digestion. Using Aegypti-Atlas, provide insights into...
Gut microbes play important roles in host physiology; however, the mechanisms underlying their impact remain poorly characterized. Here, we demonstrate that not only influence gut physiology but also alter its epithelial composition. The microbiota and pathogens both intestinal stem cell (ISC) differentiation. Intriguingly, while promotes ISC differentiation into enterocytes (EC), stimulate enteroendocrine (EE) fate long-term accumulation of EEs midgut epithelium. Importantly, evolutionarily...
The objective of this study was to examine the correlation between gene expression and lead (Pb) levels in blood children with autism (AU, n = 37) compared typically developing controls (TD, 15). We postulated that, though did not differ groups, AU might metabolize differently TD children. RNA isolated from processed on Affymetrix microarrays. Separate analyses covariance (ANCOVA) corrected for age gender were performed TD, AU, all subjects (AU + TD). To reduce false positives, only genes...
Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a powerful technique to quantify gene expression. To facilitate expression study and obtain accurate results, normalization relative stably expressed reference genes crucial. The monarch butterfly, Danaus plexippus (L.), one of the most recognized insect species for its spectacular annual migration across North America. Besides great voyages, D. has drawn attention role as bio-indicator, ranging from genetically...
Atrial fibrillation (AF) is the most common cardiac arrhythmia at clinic. Recent GWAS identified several variants associated with AF, but they account for <10% of heritability. Gene-gene interaction assumed to a significant portion missing Among loci only three were replicated in Chinese Han population, including SNP rs2106261 (G/A substitution) ZFHX3, rs2200733 (C/T near PITX2c, and rs3807989 (A/G CAV1. Thus, we analyzed among these AF loci. We demonstrated between independent populations...
The cabbage looper, Trichoplusia ni, is a globally distributed highly polyphagous herbivore and an important agricultural pest. T. ni has evolved resistance to various chemical insecticides, one of the only two insect species that have biopesticide Bacillus thuringiensis (Bt) in systems been selected for baculovirus infections. We report 333-Mb high-quality genome assembly, which N50 lengths scaffolds contigs 4.6 Mb 140 Kb, respectively, contains 14,384 protein-coding genes. High-density...
Abstract Harmonia axyridis is a voracious predator, biological control agent, and one of the world most invasive insect species. The advent next-generation sequencing platforms has propelled entomological research into genomics post-genomics era. Real-time quantitative PCR (RT-qPCR), primary tool for gene expression analysis, core technique governs genomic research. selection internal reference genes, however, can significantly impact interpretation RT-qPCR results. overall goal this study...
By suppressing the expression of genes with essential biological functions, in planta RNAi can negatively affect development and survival target pests. As a part concerted effort to assess risks transgenic crops on non-target organisms, we developed an vivo toxicity assay examine impacts ingested dsRNAs incurred monarch butterfly, Danaus plexippus (L.), iconic eco-indicator North America. To create worst case scenario, full-length v-ATPase A cDNAs from pest, western corn rootworm, Diabrotica...
Most recently, major federal regulatory agencies deregulated an in planta RNA interference (RNAi) trait against a devastating corn pest, the western rootworm Diabrotica virgifera virgifera, United States and Canada. The impact of double-stranded (dsRNA) plant-incorporated protectants (PIPs) dietary RNAi to non-target organisms, however, still needs further investigation. In this study, we assessed potential risks active dsRNA group predatory biological control agents, including Hippodamia...
Abstract Patients infected with multidrug-resistant organisms (MDROs) are known to exhibit longer hospital stays and a significantly poorer prognosis. We performed 6-year retrospective analysis of nosocomial infections reported in the orthopedics department our institution, gain valuable insights into antibiotic sensitivity infectious characteristics MDROs, order deduce effective measures control occurrence clinical practice. A retrospective, single center surveillance study (January...
Abstract Mosquitoes are prolific vectors of human pathogens, therefore a clear and accurate understanding the organization their antimicrobial defenses is crucial for informing development transmission control strategies. The canonical infection response in insects, as described insect model Drosophila melanogaster , pathogen type-dependent, with distinct stereotypical responses to Gram-negative bacteria Gram-positive bacteria/fungi mediated by activation Imd Toll pathways, respectively. To...
Gene expression in blood was correlated with mercury levels of 2- to 5-year-old boys autism (AU) compared age-matched typically developing (TD) control boys. This done address the possibility that two groups might metabolize toxicants, such as mercury, differently. RNA isolated from and gene assessed on whole genome Affymetrix Human U133 microarrays. Mercury were measured using an inductively coupled plasma mass spectrometer. Analysis covariance (ANCOVA) performed partial correlations...
While trade-offs between flight capability and reproduction is a common phenomenon in wing dimorphic insects, the molecular basis largely unknown. In this study, we examined transcriptomic differences winged wingless morphs of cotton aphids, Aphis gossypii, using tag-based digital gene expression (DGE) approach. Ultra high-throughput Illumina sequencing generated 5.30 5.39 million raw tags, respectively, from A. gossypii DGE libraries. We identified 1,663 differentially expressed...
Abstract Long noncoding RNA, RNA component of mitochondrial processing endoribonuclease (RMRP) plays an important role in cancer development and is closely correlated with prognosis patients. However, whether RMRP affects patients hepatocellular carcinoma (HCC) remains unclear. The aim the present study was to investigate expression level HCC its correlation explain effects associated mechanisms by conducting vitro study. high poor HCC. Using analysis, knockdown suppressed cell...
Few trials studied the links of food components in different diets with their induced lipidomic changes and related metabolic outcomes. Thus, we investigated specific signatures habitual modified diabetes risk by using a trial cohort.We included 231 Chinese overweight prediabetes randomized feeding Mediterranean, traditional, or transitional (control diet) from February to September 2019. Plasma profiles were measured at baseline, third month, sixth month high-throughput targeted liquid...
<title>Abstract</title> Flexible microelectrodes are ideal for chronic neural recordings but face challenges in probe insertion due to low bending strength. Here we have proposed a stiffness-tunable polyimide deep brain implantation, referred as Neurotentacle, enabled by embedded microchannels which the liquid pressure is controllable. During insertion, neurotentacle becomes stiff under elevated internal pressure, allowing penetration of tissue without additional materials or tools. Once...