Jiaxiang Gu

ORCID: 0000-0003-4000-3524
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About
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Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Orthopedic Surgery and Rehabilitation
  • Reconstructive Facial Surgery Techniques
  • Bone fractures and treatments
  • Surgical Sutures and Adhesives
  • Organ and Tissue Transplantation Research
  • Nerve injury and regeneration
  • Musculoskeletal synovial abnormalities and treatments
  • Bone Tumor Diagnosis and Treatments
  • Vascular Procedures and Complications
  • Anatomy and Medical Technology
  • Pelvic and Acetabular Injuries
  • Peripheral Nerve Disorders
  • Spine and Intervertebral Disc Pathology
  • Osteoarthritis Treatment and Mechanisms
  • Leech Biology and Applications
  • Nerve Injury and Rehabilitation
  • Virus-based gene therapy research
  • Bone health and osteoporosis research
  • Advanced Glycation End Products research
  • Periodontal Regeneration and Treatments
  • Wnt/β-catenin signaling in development and cancer
  • Silk-based biomaterials and applications
  • Selenium in Biological Systems
  • Tumors and Oncological Cases

Yangzhou University
2012-2024

Northern Jiangsu People's Hospital
2019-2024

Dalian Medical University
2024

Xuzhou Central Hospital
2013

To determine the effects of cartilage progenitor cells, bone marrow mesenchymal stem cells and chondrocytes on repair as seed cells.Porcine (CPCs), (BMSCs) (CCs) were obtained from femoropatellar joints young pigs, seeded in agarose gel a graft. During 28-day culture, proliferation ability was measured by MTT assay, gene expression Collagen I, II, Aggrecan SOX 9 qPCR. Qualitative quantitative analysis collagen, glycosaminoglycan DNA appraised immunohistochemical staining biochemical...

10.2147/dddt.s356936 article EN cc-by-nc Drug Design Development and Therapy 2022-04-01

The purpose of this study was to report our experience fingertip replantation without venous anastomosis using alternate method counter post-operative congestion.30 Patients (18 men and 12 women) with 30 amputations (Tamai zone I) were treated artery-only between March 2010 July 2014. Postoperative outflow maintained by allowing bleeding through wound gaps combined topical (12500u:250mlNS) systemic (4000 IU SC once daily) heparin. outcomes evaluated standard evaluating systems.The average...

10.1186/s40064-016-3394-8 article EN SpringerPlus 2016-10-21

This study reports our experience with reconstruction of distal fingertip degloving injuries using a single cross-finger flap based on the dorsal branch proper digital artery at middle phalanx. From January 2009 to October 2011, 18 patients (18 fingers) presented and were treated this technique. The mean size soft tissue defects was 4.5 cm in length 2.0 width. flaps 4.7 × 2.1 cm. In series, all survived completely. No complication reported, no further debunking procedure required. At...

10.1055/s-0033-1356550 article EN Journal of Reconstructive Microsurgery 2013-09-20

Introduction Usually caused by compression of the wrist's median nerve, carpal tunnel syndrome (CTS) is one most common types peripheral neuropathy. Tophi deposited under epineurium nerve compress leading to CTS, which very rare. Case presentation We report a 64-year-old man with history tophaceous gout who presented typical CTS symptoms and was admitted our hospital. A physical examination revealed swelling over right volar aspect region, he unable flex due subcutaneous rigidity. Tinel's...

10.3389/fsurg.2022.942062 article EN cc-by Frontiers in Surgery 2023-01-06

Osteoarthritis (OA) is an age-related chronic degenerative disease. Accumulation of advanced glycation end products (AGEs) induces degradation the articular extracellular matrix (ECM) and considered a critical step toward development progression OA. GPR40 well-known free fatty acid receptor, which possesses pleiotropic effects in different types diseases. However, biological function OA indistinct. The purpose present study was to determine impact agonist GW9508 on AGEs-treated...

10.2147/dddt.s239273 article EN cc-by-nc Drug Design Development and Therapy 2020-06-01

Purpose In finger reconstruction, big-toe wraparound flap (WAF) transfer provides excellent results. However, difficulty in healing and impaired function at the donor site are common. We aimed to explore an ideal method address these complications. Methods This retrospective study involved 22 patients who were treated with big toe WAF for reconstruction between 2016 2020. Patients categorized into cohorts by repair method: second-toe medial-side adjacent skin graft (cohort 1) alone 2)....

10.1097/sap.0000000000003262 article EN Annals of Plastic Surgery 2022-06-11

Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply the brain. Regeneration of neural cells critical process for repairing damaged Nogo has been identified as an inhibitor neurite outgrowth that specific In present study, Nogo-A receptor (NgR) antagonist NEP1-40 was used study effects inhibition NgR on regeneration and related Wnt signaling pathway in newborn rats. The investigation focused transcription factors regulated during repair process, together...

10.3892/mmr.2013.1579 article EN Molecular Medicine Reports 2013-07-09

To illustrate the clinical outcomes of reverse digital proper artery island flap with anastomosing palmar cutaneous branches nerve for reconstruction finger pulp defects.From December 2007 to 2017, a total 20 patients defects were treated innervated construction. Functional outcomes, aesthetic appearance, and complications evaluated. assessed according range motion, sensory grade (S0-S4), static 2-point discrimination, Semmes-Weinstein monofilament test, Cold Intolerance Severity Score....

10.1097/sap.0000000000003591 article EN Annals of Plastic Surgery 2023-06-01

Whether an innervated reverse digital artery island flap is superior to a non-innervated still remains controversial. We aimed compare the clinical outcomes of two flaps in repairing finger pulp soft tissue defects.Medical records patients who underwent reconstruction between January 2007 and December 2017 were evaluated retrospectively. A total 45 included. Twenty sensory nerve with cutaneous branches proper nerve, 25 surgery without reconstruction. Surgical results, complications function...

10.1111/ans.18180 article EN ANZ Journal of Surgery 2022-12-01

Congenital foot deformities are complex diseases influenced by genetic, environ mental, and nutritional factors. In recent years, research has increasingly focused on the effects of trace elements during pregnancy (such as zinc, selenium, copper, iron, phosphate) fetal development. Although observational studies sug gest that these may be associated with congenital deformities, their causal relationship remains unclear. This study employs Mendelian Random ization method, using genetic...

10.1101/2024.10.26.24316184 preprint EN cc-by 2024-10-27

To explore the effectiveness of modified anterolateral thigh perforator flap pedicled by cross-bridge microvascular anastomosis in treatment soft tissue defects middle and lower segments leg.Between March 2011 June 2015, 15 cases with skin legs were treated. There 9 males 6 females, aged 22-48 years (mean, 32.6 years). Of whom, 8 patients caused traffic accidents, 5 machine twist, 2 crash injury heavy object. The mean interval from to admission was 82.6 hours (range, 1 week). area defect...

10.7507/1002-1892.201705022 article EN PubMed 2017-10-15
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