A5101790171- Protease and Inhibitor Mechanisms
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Cleft Lip and Palate Research
- Cell Adhesion Molecules Research
- Renal and related cancers
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Connective tissue disorders research
- Tracheal and airway disorders
- Glycosylation and Glycoproteins Research
- Bone and Dental Protein Studies
- RNA modifications and cancer
- FOXO transcription factor regulation
- Bioactive Compounds in Plants
- Seaweed-derived Bioactive Compounds
- TGF-β signaling in diseases
- Abdominal Surgery and Complications
- Vascular Malformations and Hemangiomas
- Infant Nutrition and Health
- Medical Practices and Rehabilitation
- Protein Tyrosine Phosphatases
- Voice and Speech Disorders
- Single-cell and spatial transcriptomics
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Shandong University
2008-2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Army Medical University
2023
Chongqing Medical University
2023
Xuzhou Central Hospital
2021
Shandong Provincial QianFoShan Hospital
2021
Shandong First Medical University
2021
Background Secreted protein acidic and rich in cysteine (SPARC), a calcium-binding matricellular glycoprotein, is implicated the progression of many cancers. In this study, we investigated expression function SPARC ovarian cancer. Methods cDNA microarray analysis was performed to compare gene profiles highly invasive low subclones derived from SKOV3 human cancer cell line. Immunohistochemistry (IHC) staining investigate total 140 tissue specimens. functional assays, effects knockdown on...
Objective This study was to explore the role of EFEMP1 in ovarian tumor progression and its relationship with prognosis carcinoma. Methods mRNA protein expressions normal tissue, tumor, high invasive subclones low were evaluated by immunohistochemistry real time RT-PCR. Serum levels patients measured ELISA assay. To assess angiogenic properties EFEMP1, VEGF microvessel density analyzed carcinoma immunohistochemistry. Results expression up-regulated carcinoma, positively correlated MVD VEGF,...
Secreted protein acidic and rich in cysteine (SPARC) is associated with the progression of numerous types cancer. However, role SPARC cervical cancer has not yet been adequately elucidated. In current study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) immunohistochemistry were employed to evaluate mRNA expression normal tissue, intraepithelial neoplasia (CIN) addition, three epithelial-mesenchymal transition (EMT) markers (E-cadherin, N-cadherin vimentin) detected...
High-mobility group box 1 (HMGB1), a nuclear and extracellular protein, is implicated in the development progression of some types cancers. However, no information available to date regarding function HMGB1 ovarian cancer. In this study, we performed cDNA microarray analysis identified as gene dramatically elevated highly invasive subclone S1 compared with low S21 derived from same cell line SKOV3. Then lentivirus vector shRNA was constructed infected S1, A1, HO8910PM. Real-time RT-PCR,...
EFEMP1, a kind of extracellular matrix (ECM) protein, has been suggested to correlate with the development different types carcinoma. However, its functions in ovarian cancer remain unclear. In our study, we performed cDNA microarray analysis and identified EFEMP1 dramatically elevated highly invasive subclone, compared low subclone. Lentivirus transfection experiments were constructed afterwards. The results demonstrated that knockdown significantly inhibited cell proliferation induced...
Abstract A biskyrmion consists of two bound, topologically stable, skyrmion spin textures. These coffee‐bean‐shaped objects are observed in real space thin plates using Lorentz transmission electron microscopy (LTEM). From LTEM imaging alone, it is not clear whether biskyrmions surface‐confined objects, or, analogous to skyrmions noncentrosymmetric helimagnets, 3D tube‐like structures a bulk sample. Here, the form factor investigated single‐ and polycrystalline‐MnNiGa samples small‐angle...
Mesenteric lymphangioma (ML) in adults is a very rare disease. We report six hospitalized adult patients with ML our hospital between January 2013 and July 2018 to investigate the characteristics prognosis of adults.The male-to-female ratio was 3:3, median age at diagnosis 55.2 years. Clinical manifestations varied; however, most were acute cases (5/6). No history trauma reported. None (0/6) accurately diagnosed emergency outpatient departments. cysts identified four (66.7%) by abdominal...
Fibulin-4, a member of the fibulin family extracellular glycoproteins, is implicated in progressions some cancers. However, no information has been available to date regarding function fibulin-4 ovarian carcinoma progression.In this study, mRNA and protein expression normal tissue, tumor, high invasive subclones low were evaluated by immunohistochemistry real time reverse transcriptase-polymerase chain reaction (RT-PCR). The serum levels fibulin-4, cancer antigen 125 (CA-125) cerbohydrate...
The role of Galectin-9 (Gal-9) in the pathogenesis rheumatoid arthritis (RA) remains unclear. This study aimed to investigate mechanism action and therapeutic potential Gal-9 RA. We detected expression clinical samples, explored function by knockdown overexpression fibroblast-like synoviocytes (FLSs), further verified it collagen-induced (CIA) model. found that levels were considerably elevated RA synovium than osteoarthritis (OA) patients. A substantial decrease was demonstrated after tumor...
To evaluate the outcomes of immune checkpoint inhibitor (ICI)-based treatments versus classical chemotherapy for metastatic non-small cell lung cancer (NSCLC) patients who develop epidermal growth factor receptor tyrosine kinase (EGFR-TKI) resistance and to explore population that may benefit from ICI-based therapy.All had previously received EGFR-TKI therapy at two centers in China developed targeted therapies were included. Progression-free survival (PFS) overall (OS) utilized study...
Mammalian target of rapamycin (mTOR), a serine/threonine kinase involved in cell proliferation, survival, metabolism and immunity, was reportedly activated various cancers. However, the clinical role mTOR renal carcinoma (RCC) is controversial. Here we detected expression prognosis total phosphorylated (p-mTOR) clear RCC (ccRCC) patients, explored interactions between immune infiltrates ccRCC. The protein level p-mTOR determined by western blotting (WB), their evaluated 145 ccRCC 13...
Abstract Background AdipoR2, which belongs to the seven-transmembrane-domain receptor family, has been shown play an important role in development of human tumours, but underlying mechanisms are poorly understood. In this study, we found that AdipoR2 expression correlates with glioma grade. addition, also investigated behind antiproliferative effects U251 cells (a cell line) using colony formation and WST-8 growth assays. Methods The line was cultured vitro. Western blotting used detect...
A method based on magnetization is proposed to predict the induced magnetic field of naval vessels. We first deduce a formula calculate in internal region magnetized objects from viewpoint magnetization，and then use define point-function demagnetizing tensor and prove some properties tensor. Finally we this develop new vessels nonuniform applied field，and call it Magnetization Method，in which used. Compared with traditional methods，the features low computational cost，high precision manifest...
The aim of the present study was to develop a novel method for identifying pathways associated with renal cell carcinoma (RCC) based on gene co-expression network. A framework established where network derived from database as well various approaches. First, backbone differentially expressed (DE) genes between RCC patients and normal controls constructed by Search Tool Retrieval Interacting Genes/Proteins (STRING) database. co-expressed links were detected Pearson's correlation, empirical...
Abstract Recent advances in single-cell RNA sequencing (scRNA-seq), enriched the knowledge of heterogeneity tumor-infiltrating lymphocytes (TIL) for understanding mechanisms cancer initiation and progression. However, alternative splicing (AS), as one important regulatory factors heterogeneity, has been poorly investigated. Here, we proposed a computational tool, DESJ-detection, which could fast accurately detect differentially expressed junction (DESJ) between cell groups at level. We...