A5064211192- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Glioma Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Management of metastatic bone disease
- Oral health in cancer treatment
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
Tohoku University
2020-2025
Kyoto Prefectural University of Medicine
2025
Hokkai Gakuen University
2024
Yamagata Prefectural Central Hospital
2019-2024
Suzuki (Japan)
2022-2023
Tochigi Medical Center
2023
Tohoku Medical and Pharmaceutical University
2023
Tokai University
2023
Kokura Memorial Hospital
2013-2022
Miyagi Prefectural Hospital Organization
2022
The authors identified eight patients with Ullrich disease in whom collagen VI was present the interstitium but absent from sarcolemma. By electron microscopy, never linked to basal lamina. These findings suggest that these it is not total absence of muscle failure anchor lamina cause disease. Only one had a mutation gene, suggesting primary abnormality most involved some other molecules.
Abstract Background Palliative radiotherapy for gastric cancer bleeding has been reported to be a safe and effective treatment, but predictive factors achievement of hemostasis overall survival have not established. Methods In this retrospective study, 120 courses palliative in 117 patients 4 institutes Japan were reviewed with approval the ethical committee each institute. The rate achieving was evaluated by 50% or more reduction red blood cell transfusion before after start radiotherapy,...
A novel bone-resorbing factor was cloned using an expression cloning technique, which involved a Xenopus oocyte system and assay for osteoclast formation. candidate clone isolated from BW5147 mouse T-lymphoma cell cDNA library. Sequencing analysis identified the as gamma-glutamyltranspeptidase (GGT), is enzyme in glutathione metabolism. The addition of purified GGT protein to bone marrow culture effectively induced formation osteoclasts. An antibody against inhibited but not enzymatic...
Background. Allergic fungal airway diseases, such as asthma and allergic bronchopulmonary mycosis (ABPM), are often difficult to manage with medical treatment alone; therefore, environmental exposure should be accurately evaluated minimized. In the present study, we established a method evaluate eliminate contamination in household air conditioners (ACs). Methods. fall of 2020, an survey living rooms was conducted 17 Japanese residences patients ABPM or related diseases. Household ductless...
The perioperative anesthetic management of patients with severe airway obstruction due to advanced lung cancer poses significant challenges, and no standardized protocols have been established. A 49-year-old man tracheal stenosis extrinsic tumor compression underwent successful stenting supported by venoarterial extracorporeal membrane oxygenation (V-A ECMO). Due the high risk collapse, we initiated ECMO under dexmedetomidine sedation while preserving spontaneous breathing. In addition...
<title>Abstract</title> Background Stereotactic radiotherapy (SRT) for kidney cancer, particularly when tumours are situated near critical organs-at-risk (OARs), presents significant challenges in achieving optimal dose delivery. MR-guided online adaptive (MRgoART) offers a promising solution by allowing real-time anatomical modification and plan reoptimisation. However, the ideal strategy prescription selection reoptimisation remains unclear. Methods This single-centre planning study...
Gamma-aminobutyric acid (GABA) is an important neurotransmitter, but recent reports have revealed the expression of GABAergic components in peripheral, non-neural tissues. GABA administration induces natriuresis and lowers blood pressure, suggesting renal targets. However, systematic evaluation has not been reported. In this study, kidney cortices Wistar-Kyoto rats (WKY) were used to assay for messenger RNAs GABA-related molecules using RT-PCR. WKY cortex, GABAA receptor subunits, α1, β3, δ,...
In clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is not fully understood. The purpose this retrospective study was to investigate factors related distant metastasis-free (DMFS), progression-free (PFS) overall (OS) IMRT for locally advanced non-small cell lung cancer (LA-NSCLC).All patients who were treated with conventional fractionated LA-NSCLC between April 2016 March 2021 eligible. Time-to-event data...
Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan November 2022 for treating non-hospitalized patients with mild-to-moderate COVID-19. However, confirmation of its real-world clinical effectiveness is limited.
Abstract The purpose of this retrospective study was to investigate survival outcomes and irradiated tumor control (local [LC]) locoregional (LRC) after stereotactic body radiotherapy (SBRT) for T1 or recurrent (rT1) kidney cancer. Twenty-nine nonconsecutive patients with 30 tumors were included. SBRT doses 70 Gy, 60 Gy 50 in 10 fractions prescribed a linear accelerator using daily image guidance. Kaplan–Meier method used estimate time-to-event outcomes, the log-rank test compare curves...
The efficacy of intravenous administration 400 mg carboplatin/m2 body surface area over 60 minutes combined with hyperbaric oxygenation (HBO) therapy (0.2 MPa for min) was investigated in 6 Japanese patients (aged 36-67 years) malignant or brainstem gliomas. Plasma ultra-filtrate samples were analyzed by high-performance liquid chromatography to evaluate the relationship between and pharmacokinetics. Brain tumor response evaluated magnetic resonance imaging as a function maximum plasma...
Xerostomia is one of the most common adverse events radiotherapy in head and neck cancer patients. There have been many reports on functional changes parotid gland after radiation therapy, but there few volume its relationship with oral quality life (QOL) even fewer longitudinal change volume. The purpose this study was to evaluate long-term intensity-modulated (IMRT) for nasopharyngeal carcinoma between irradiation dose xerostomia symptoms.We retrospectively analyzed 26 patients treated by...
Abstract Background The abscopal effect is a phenomenon in which tumor located far from irradiated lesions regresses. We have experienced case both intracranial and extracranial showed an after radiotherapy for spinal metastases of unknown primary. report the differential lesions. Case presentation A 57-year-old Japanese man was diagnosed with multiple lung nodules, bone metastases, brain metastases. results pathological examination at previous hospital he visited suggested adenocarcinoma...
Immunohistochemical localization of gamma-glutamyl transpeptidase (gamma-GTP) in rat liver during 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) hepatocarcinogenesis was investigated and compared with sites gamma-GTP activity. Immunohistochemically, stained the apical border proliferating oval cells early stages azo-dye carcinogen feeding. After 7 weeks, multiple hyperplastic nodules appeared which localized bile canaliculi. In hepatoma tissues, positive staining for observed...
Aim To establish prehospital triage in accordance with the new guidelines for endovascular therapy, we retrospectively analyzed monitoring data of city‐wide transportation system using Maria Prehospital Stroke Scale ( MPSS ), a novel stroke scale emergency medical technicians EMT s) to predict likelihood thrombolytic therapy after transportation. Methods Kawasaki City, Japan, has six comprehensive centers CSC and primary PSC s). In s, can be carried out 24 h day, 7 days week, but not s....
Abstract Purpose Whole-brain radiotherapy (WBRT) may not be beneficial for patients with brain metastases (BMs). The Glasgow Prognostic Score (GPS) is a suggested prognostic factor malignancies. However, GPS has never been assessed in BMs who have undergone WBRT. purpose of this study was to determine whether can used identify subgroups poor prognosis, such as recursive partitioning analysis (RPA) Class 2 and 3, will receive clinical benefits from Materials methods A total 180 Japanese were...