A5101417997- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Non-Invasive Vital Sign Monitoring
- Phonocardiography and Auscultation Techniques
- Anesthesia and Sedative Agents
- Dermatology and Skin Diseases
- Hemodynamic Monitoring and Therapy
- Diet, Metabolism, and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Contact Dermatitis and Allergies
- Time Series Analysis and Forecasting
- Heavy Metal Exposure and Toxicity
- Fungal Infections and Studies
- Stress Responses and Cortisol
- Amyotrophic Lateral Sclerosis Research
- Parathyroid Disorders and Treatments
- Physical Activity and Health
- Medical Imaging Techniques and Applications
- Speech and Audio Processing
- Liver Disease and Transplantation
- Agriculture and Rural Development Research
- Aluminum toxicity and tolerance in plants and animals
Kyoto Prefectural University of Medicine
2014-2025
Osaka University Hospital
2019-2024
Yodogawa Christian Hospital
2023
University Hospital Kyoto Prefectural University of Medicine
2023
Osaka University
2014-2020
Shionogi (Japan)
2014-2018
Futaba (Japan)
2014-2016
Nagoya University
2015
Mie University Hospital
2013-2014
Mie University
2012-2014
SummaryBackgroundThe loss of corneal epithelial stem cells from the limbus at edge cornea has severe consequences for vision, with pathological manifestations a limbal stem-cell deficiency (LSCD) difficult to treat. Here, best our knowledge, we report world's first use cell sheets derived human induced pluripotent (iPSCs) treat LSCD.MethodsThis non-randomised, single-arm, clinical study involved four eyes patients LSCD Department Ophthalmology, Osaka University Hospital. They comprised woman...
The aim of the present study was to evaluate perioperative risk factors for development nonalcoholic fatty liver disease (NAFLD) after pancreaticoduodenectomy (PD), paying special attention remnant pancreatic volume (RPV) and postoperative infection.We reviewed charts 110 patients who had been followed more than 6 months PD. These were classified into two groups according RPV measured by CT volumetry at one month: large-volume group (LVG) (10 ml or more, n = 75) small-volume (SVG) (less 10...
Anthocyanins exhibit various vivid colors from red through purple to blue and are potential sources of food colorants. However, their usage is restricted because instability, especially as a colorant. The sepal color Hydrangea macrophylla due metal complex named "hydrangea-blue complex" composed delphinidin 3-O-glucoside, 1, 5-O-caffeoylquinic acid, 2, and/or 5-O-p-coumaroylquinic 3, copigments, Al(3+) in aqueous solution at approximately pH 4.0. the ratio each component ins not...
Abstract Quantitative analysis of itching in patients with dermatitis including atopic ( AD ) is indispensable for the evaluation disease activity and response to therapy. However, objective system limited. We have developed a new quantitative scratching behavior detection using wristwatch‐type sound detector. The scratch detected on wrist recorded personal computer through filtering, squaring smoothing process by specific hardware. Subsequently, data automatically processed judged movement...
Abstract Purpose To compare plain computed tomography (CT) and chemical‐shift MR imaging (CSI) for establishing a noninvasive method to estimate the degree of steatosis. Materials Methods A total 58 patients who had histological proof liver tissue underwent CT and/or CSI within two weeks, were studied. They consisted 38 living donor candidates 20 surgery without hepatitis or cirrhosis. The index (CTI) (MRI) defined correlated grades Correlation was also performed exclusively mild steatosis...
Intraductal papillary mucinous neoplasms (IPMN) are known to show a transition from adenoma carcinoma accompanied by several molecular abnormalities. ATM-Chk2-p53 DNA damage checkpoint activation, which is involved in prevention of the progression tumors, was analyzed evaluate role IPMNs.One hundred and twenty-eight IPMNs were classified into four groups (intraductal adenoma, borderline IPMN, noninvasive intraductal carcinoma, invasive carcinoma) stained immunohistochemically using antibody...
The perioperative anesthetic management of patients with severe airway obstruction due to advanced lung cancer poses significant challenges, and no standardized protocols have been established. A 49-year-old man tracheal stenosis extrinsic tumor compression underwent successful stenting supported by venoarterial extracorporeal membrane oxygenation (V-A ECMO). Due the high risk collapse, we initiated ECMO under dexmedetomidine sedation while preserving spontaneous breathing. In addition...
Abstract To investigate the conjunctival microbiota and association between development of mucosa-associated lymphoid tissue (MALT) lymphoma dysbiosis, DNA samples were collected from 25 MALT patients healthy controls. compare microbiota, following four body locations: conjunctiva, meibomian gland, periocular skin hand. Extracted was analyzed by 16S rRNA sequences, libraries sequenced on an Illumina MiSeq sequencer. The differences in bacteria characterized using principal coordinate...
Background: The purpose of this study was to determine whether the presence fatty liver is associated with an alteration in myocardial perfusion reserve (MPR). Methods and Results: A retrospective analysis 65 asymptomatic subjects who underwent both plain abdominal computed tomography cardiac magnetic resonance imaging (MRI), had normal left ventricular wall motion, no regional ischemia scar on MRI performed. Stress rest were analyzed by Patlak plot method quantify blood flow (MBF) MPR 16...
We evaluated clinicopathological factors affecting survival and recurrence after initial hepatectomy in non-B non-C (NBNC) hepatocellular carcinoma (HCC) patients with comparison to hepatitis B or C virus, paying attention relationship between alcohol consumption histopathological findings. The medical records on the 201HCC who underwent January 2000 April 2013 were retrospectively reviewed. NBNC had higher prevalence of hypertension (47.4%), diabetes mellitus (35.5%), (>20 g/day)...
Abstract Background Anesthesiologists are required to maintain an optimal depth of anesthesia during general anesthesia, and several electroencephalogram (EEG) processing methods have been developed approved for clinical use evaluate depth. Recently, the Hilbert–Huang transform (HHT) was introduced analyze nonlinear nonstationary data. In this study, we assessed whether changes in EEG characteristics that analyzed by HHT useful monitoring anesthesia. Methods This retrospective observational...
Background Ventilator-associated conditions (VACs), for which new surveillance definitions and methods were issued by the Center Disease Control Prevention (CDC), are respiratory complications occurring in conjunction with use of invasive mechanical ventilation related to adverse outcomes critically ill patients. However, date, risk factors VACs have not been adequately established, leading a need developing better understanding risks. The objective this study was explore care-related as...
Vascular endothelial growth factor (VEGF)-targeted therapies show significant antitumor effects for advanced clear cell renal carcinomas (CC-RCCs). Previous studies using VEGF inhibitors in mice models revealed that VEGF-dependent capillaries were characterized by the existence of fenestrations (EFs). In this study, we with abundant EFs did exist, particularly CC-RCCs harboring VHL mutation. This finding was recapitulated xenograft models, which tumors from null cells showed more compared to...
Summary The return or Poincaré plot is a non‐linear analytical approach in two‐dimensional plane, where timed signal plotted against itself after time delay. Its scatter pattern reflects the randomness and variability signals. Quantification of electroencephalogram has potential to determine anaesthesia depth. We quantified degree dispersion (i.e. standard deviation, SD ) along diagonal line electroencephalogram‐Poincaré (named as 1/ 2), compared 2 values with spectral edge frequency 95 (...
The molecular pathway of autonomous growth the parathyroid glands in uremic patients is poorly understood. Loss heterozygosity at recently identified multiple endocrine neoplasia type 1 (MEN1) gene locus on chromosome 11q13 has been found a subset from with refractory hyperparathyroidism. To clarify role MEN1 tumorigenesis, we analyzed 81 22 Japanese for allelic loss chromosomal arm DNA using 3 flanking markers (PYGM, D11S4946, and D11S449) mutations MEN1-coding exons by PCR-based single...