A5044503703- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Digital Imaging for Blood Diseases
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Gastrointestinal Tumor Research and Treatment
- Fibroblast Growth Factor Research
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Research Studies
- Inflammasome and immune disorders
- Mast cells and histamine
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Lymphatic System and Diseases
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Full-Duplex Wireless Communications
Istituto Tumori Bari
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2025
Ospedale San Paolo
2013-2018
University of Bari Aldo Moro
1999-2017
Azienda Unita' Sanitaria Locale Di Modena
2017
Cancer Institute (WIA)
2010
Casa Sollievo della Sofferenza
2009
Johns Hopkins University
2009
Università Campus Bio-Medico
2009
Ospedale Maggiore di Lodi
2003
Abstract The antineoplastic effect of paclitaxel is mainly related to its ability bind the β subunit tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. relevance Class I β‐tubulin characteristics have also been confirmed in clinical setting where mutations paclitaxel‐binding site resistance non small cell lung ovarian cancers. In present study, we verified hypothesis a relationship between molecular alterations sensitivity panel breast lines with different drug IC...
<h2>Abstract</h2> Percutaneous core biopsy (CB) has been introduced to increase the ability of accurately diagnosing breast malignancies without need resorting surgery. Compared conventional automated 14 gauge needle (NCB), vacuum-assisted (VANCB) allows obtaining larger specimens and recognized advantages particularly when radiological pattern is represented by microcalcifications. Regardless technical improvements, a small percentage percutaneous CBs performed detect lesions are still...
Histological assessment of colorectal cancer (CRC) tissue is a crucial and demanding task for pathologists. Unfortunately, manual annotation by trained specialists burdensome operation, which suffers from problems like intra- inter-pathologist variability. Computational models are revolutionizing the Digital Pathology field, offering reliable fast approaches challenges segmentation classification. With this respect, an important obstacle to overcome consists in stain color variations among...
Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored MCs granules, is one most active. However, no available concerning role primary human breast cancer. In this study, we have evaluated correlations between number positive tryptase (MCDPT), area occupied by (MCAPT) and microvascular density (MVD) endothelial (EA) series 88 T1-3, N0-2 M0 female cancer, means...
Abstract Aberrant promoter methylation of several known or putative tumor suppressor genes occurs frequently during carcinogenesis, and this epigenetic change has been considered as a potential molecular marker for cancer. We examined the status nine (APC, CDH1, CTNNB1, TIMP3, ESR1, GSTP1, MGMT, THBS1, TMS1), by quantitative specific PCR. Synchronous preinvasive lesions (atypical ductal hyperplasia and/or carcinoma in situ) invasive breast from 52 patients, together with pure 24 patients 12...
Nuclei identification is a fundamental task in many areas of biomedical image analysis related to computational pathology applications. Nowadays, deep learning the primary approach by which segment nuclei, but accuracy closely linked amount histological ground truth data for training. In addition, it known that most hematoxylin and eosin (H&E)-stained microscopy nuclei images contain complex irregular visual characteristics. Moreover, conventional semantic segmentation architectures grounded...
Abstract Several studies have emphasised how positive and negative human papillomavirus (HPV+ HPV−, respectively) oropharyngeal squamous cell carcinoma (OPSCC) has distinct molecular profiles, tumor characteristics, disease outcomes. Different radiomics-based prediction models been proposed, by also using innovative techniques such as Convolutional Neural Networks (CNNs). Although some of these reached encouraging predictive performances, there evidence explaining the role radiomic features...
The segmentation and classification of cell nuclei are pivotal steps in the pipelines for analysis bioimages. Deep learning (DL) approaches leading digital pathology field context detection classification. Nevertheless, features that exploited by DL models to make their predictions difficult interpret, hindering deployment such methods clinical practice. On other hand, pathomic can be linked an easier description characteristics classifiers making final predictions. Thus, this work, we...
Abstract Purpose To describe the ocular manifestations in a cohort of patients with systemic sarcoidosis (SS). Recent advances pathophysiology, diagnosis, and therapy SS are also discussed. Methods Data from 115 Italian diagnosed between 2005 2016 were retrospectively reviewed. All but first 17 underwent comprehensive ophthalmologic examination. The diagnosis was based on clinical features, demonstration non-caseating granulomas biopsies involved organs, multiple imaging techniques....
Abstract Background Ocular manifestations of granulomatosis with polyangiitis (GPA) have been reported in a limited number studies and largely variable frequency. Here we report on the clinical, diagnostic, therapeutic features cohort 63 GPA patients, particular regard to 22 them ophthalmic involvement (35%). Methods Clinical manifestations, results immunological findings, histopathological pictures, imaging data, Birmingham Vasculitis Activity Score, regimens, outcomes were retrospectively...
Inflammasome complexes play a pivotal role in different cancer types. NOD-like receptor protein 3 (NLRP3) inflammasome is one of the most well-studied inflammasomes. Activation NLRP3 induces abnormal secretion soluble cytokines, generating advantageous inflammatory surroundings that support tumor growth. The expression levels NLRP3, PYCARD and TLR4 were determined by immunohistochemistry cohort primary invasive breast carcinomas (BCs). We observed expressions non-tumor vs areas...
BACKGROUND: Anaplastic lymphoma kinase (ALK) rearrangement represents a landmark in the targeted therapy of non–small cell lung cancer (NSCLC). Immunohistochemistry (IHC) is sensitive and specific method to detect ALK protein expression, possibly an alternative fluorescence situ hybridization (FISH). In this study, concordance FISH IHC determine status was evaluated, particularly focusing on discordant cases. MATERIALS AND METHODS: tested by validated (Ventana (D5F3) CDx Assay) 95 NSCLCs....
Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) ATP-sensitive potassium (KATP) channels containing SUR2A Kir6.1 subunits, respectively, KATP channels. Pathological consequences CS have been reported for cardiac smooth muscle cells but skeletal are unknown. Children with show hypotonia adult manifest fatigability. We analyzed properties Kir6.1[V65M] mice, by measurements forelimb strength ultrasonography hind-limb muscles, as well...
Published data strongly suggest that tumor progression and malignancy are associated with increased angiogenesis. However, no have been published concerning the relationship between microvascular density (MVD), cytosol, blood vascular endothelial growth factor (VEGF) concentrations in canine non-Hodgkin lymphoma (C-NHL), a neoplasm shares biological clinical characteristics human NHL. We evaluated MVD serum (S), platelet-poor plasma (P-PP), plasma-activated platelet rich (P-APR) VEGF...
Purpose: The thymidine phosphorylase (TP) is a key enzyme involved in the metabolism of pyrimidines. Inhibition or downregulation this causes accumulation me-tabolites with consequences DNA replication. TP regulates angiogenesis and chemo-tactic activity endothelial cells. Different studies showed presence upregula-tion human cancer but correlation between expression microvascular density (MVD) canine mammary tumors unknown. aim study was to in-vestigate possible MVD tumor cells different...
The aim of the study was to evaluate performance immunohistochemical MS110 expression in a series familial and sporadic breast cancer patients. An performed on TMA samples from 93 94 patients with (7/94) without BRCA1 germline mutations. protein level evaluated using monoclonal antibody. Immunohistochemistry, samples, showed positive nuclear staining for 34 37 tumours, respectively. All tumours carrying mutations complete loss both ERalpha expression, regardless type mutation. percentage...
K-RAS and BRAF gene mutations are mandatory to set anti-EGFR therapy in metastatic colorectal cancer (mCRC) patients. Due the relationship of these with tumor epigenotype, we hypothesized potential role oncosuppressor methylation genes involved K-RAS/BRAF pathway (CDKN2A, RASSF1A, RARbeta suppressor genes) inhibiting EGFR signaling cascade. Primary synchronous liver tissues 75 mCRC patients were characterized for promoter by QMSP mutations. RARbeta, CDKN2A methylated 82%, 35%, 26% primary...