A5008708299- Advanced Graph Theory Research
- Graph Labeling and Dimension Problems
- Research on Leishmaniasis Studies
- Graph theory and applications
- Interconnection Networks and Systems
- Limits and Structures in Graph Theory
- graph theory and CDMA systems
- Complexity and Algorithms in Graphs
- Rings, Modules, and Algebras
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Polyomavirus and related diseases
- Advanced Topics in Algebra
- Vascular Anomalies and Treatments
- Viral-associated cancers and disorders
- Pharmacological Effects of Natural Compounds
- Nonmelanoma Skin Cancer Studies
- Cancer Mechanisms and Therapy
- Cervical Cancer and HPV Research
- Vascular Malformations and Hemangiomas
- Advanced Drug Delivery Systems
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Macrophage Migration Inhibitory Factor
- Homelessness and Social Issues
Centre international de recherche sur le cancer
2018-2024
Heidelberg University
2022-2024
University Hospital Heidelberg
2022-2024
Dinajpur Medical College
2024
University Medical Centre Mannheim
2023
University of Delhi
2007-2022
de Duve Institute
2020
University of Calcutta
2013-2019
Florida International University
2018-2019
Bombay College of Pharmacy
2017-2018
Abstract CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this cargo to brain remains as a challenge. In research, for first time, we demonstrated magnetically guided non-invasive nano-formulation (NF), composed Cas9/gRNA bound with magneto-electric nanoparticles (MENPs), across blood-brain barrier (BBB) inhibit HIV-1 infection in microglial (hμglia)/HIV (HC69) cells. An optimized ac-magnetic field 60 Oe was applied...
Vascular networks form, remodel and mature under the influence of both fluid shear stress (FSS) soluble factors. Physiological FSS promotes maintains vascular stability via synergy with Bone Morphogenic Protein 9 (BMP9) BMP10. Conversely, mutation BMP receptors ALK1, Endoglin or downstream effector SMAD4 leads to Hereditary Hemorrhagic Telangiectasia (HHT), characterized by fragile leaky arterial-venous malformations (AVMs). But how endothelial cells (EC) integrate signals in development...
Chronic pancreatitis is characterized by progressive loss of exocrine and endocrine functions the pancreas considered to be single most important cause for development pancreatic cancer. Recent evidence suggests that inflammation oxidative stress play pivotal roles in clinical conditions like pancreatitis, type 2 diabetes mellitus, metabolic syndrome. Nonetheless, molecular signaling pathways linking inflammation, stress, cell death are not yet well defined. In this study, bacterial...
One of the mechanisms for establishment infection employed by intra-macrophage pathogen-like Leishmania is inhibition oxidative burst-mediated macrophage apoptosis to protect their niche survival and replication. We tried elucidate underlying mechanism this using H2O2 induction apoptosis. donovani-infected macrophages were much more resistant H2O2-mediated compared with control. Although infected cells capable comparable reactive oxygen species production, there was less activation...
This study reports the self-assembly and application of a naphthalene diimide (NDI)-appended peptide amphiphile (PA). H-bonding among moiety in conjunction with π-stacking between NDI hydrophobic interactions within alkyl chain are major driving forces behind stepwise aggregation PA to form hydrogels. The produced efficient self-assemblies water, forming nanofibrous network that further formed self-supportive hydrogel. molecule followed three-step mechanism. At lower concentration (50 μM),...
Programmed death‐1 receptor (PD‐1) expressed in many immune cells is known to trigger T‐cell exhaustion but the significance of macrophage‐associated PD‐1 relevance macrophage apoptosis not known. This study aimed delineate whether pathway has any role eliciting and, if so, then how intra‐macrophage parasite, Leishmania donovani modulates for protecting its niche. Resting macrophages when treated with H 2 O showed increased expression and apoptosis, which was further enhanced on agonist...
Suppression of host oxidative burst is essential for survival the intracellular parasite
Apoptosis is one of the mechanisms used by host cells to remove unwanted intracellular organisms, and often found be subverted pathogens through use anti-apoptotic proteins. In present study, with help in vitro vivo approaches, we documented that macrophage protein myeloid cell leukemia 1 (MCL-1) exploited intra-macrophage parasite Leishmania donovani protect their "home" from actinomycin D-induced mitochondria-dependent apoptosis. Among all BCL-2 family members, infection preferentially...
Intramacrophage pathogen Leishmania donovani escapes host immune response by subverting Toll-like receptor (TLR) signaling, which is critically regulated protein ubiquitination. In the present study, we identified tumor necrosis factor receptor-associated (TRAF) 3, degradative ubiquitination of essential for TLR4 activation, as a target to deactivate LPS-mediated signaling. We used LPS-treated RAW 264.7 cells and compared TLR4-mediated in these with L. + LPS costimulated macrophages. TRAF3,...
ABSTRACT Previously, we documented the role of programmed death-1 (PD-1, also known as PDCD1) pathway in macrophage apoptosis and downregulation this signaling during infection by intra-macrophage parasite Leishmania donovani. However, found that, late phase infection, PD-1 expression was significantly increased without activating host cell apoptosis; here show that inhibition led to markedly decreased survival, along with production TNFα, IL-12, reactive oxygen species (ROS) nitric oxide...
Signal-responsive gene expression is essential for vascular development, yet the mechanisms integrating signaling inputs with transcriptional activities are largely unknown. Here we show that RNF20, primary E3 ubiquitin ligase histone H2B, plays a multifaceted role in sprouting angiogenesis. RNF20 mediates RNA polymerase (Pol II) promoter-proximal pausing at genes highly paused endothelial cells, involved VEGFA signaling, stress response, cell cycle control and mRNA splicing. It also...
ABSTRACT Intracellular survival of Leishmania donovani demands rapid production host ATP for its sustenance. However, a gradual decrease in intracellular spite increased glycolysis suggests efflux during infection. Accordingly, upon infection, we show here that is exported and the major exporter was pannexin-1, leading to raised extracellular levels. Extracellular shows after initial increase, analysis cell surface ATP-degrading enzymes revealed induction ectonucleotidases CD39 CD73....
18β-Glycyrrhetinic acid (GRA), a natural immunomodulator, greatly reduced the parasite load in experimental visceral leishmaniasis through nitric oxide (NO) upregulation, proinflammatory cytokine expression, and NF-κB activation. For GRA-mediated effect, primary kinase responsible was found to be p38, analysis of phosphorylation kinetics as well studies with dominant-negative (DN) constructs revealed mitogen-activated protein 3 (MKK3) MKK6 immediate upstream regulators p38. However,...
Merkel cell carcinoma was first described in 1972 as a neuroendocrine tumor of skin, most cases which were reported 2008 to be caused by PyV named polyomavirus (MCPyV), the linked human cancer. Thereafter, numerous studies have been conducted understand etiology this virus-induced carcinogenesis. However, it is still new field, and much work needed molecular pathogenesis MCC. In current work, we sought identify host genes specifically deregulated MCPyV, opposed other PyVs, order better...
Abstract To study the interaction between HIV and other carcinogenic infections in conjunctival squamous cell carcinoma (SCC), we evaluated presence of a broad spectrum human viruses conjunctiva specimens. Beta Human papillomavirus (HPV; n = 46), gamma HPV (n 52), polyomaviruses 12) herpes 3) was determined DNA extracted from 67 neoplastic 55 non‐neoplastic tissues HIV‐positive negative subjects by Luminex‐based assays. Next‐generation sequencing (NGS) also used to further characterize...
Tumor suppressors can exert pro-proliferation functions in specific contexts. In the beta human papillomavirus type 38 (HPV38) experimental model, viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form keratinocytes (HKs), promoting cellular proliferation. Inactivation by different means strongly decreases proliferation HPV38 E6/E7 HKs. This is phosphorylated at S392 double-stranded RNA-dependent protein kinase PKR, which highly activated HPV38. PKR-mediated...
A set D ⊆ V(G) is a 2-point dominating (2-psd set) of graph G if for any subset S V-D, there exists non-empty T containing at most two vertices such that the subgraph <S ∪ T> induced by connected. The domination number G, denoted γ2ps(G), minimum cardinality 2-psd G. In this paper we give γ2ps(G) cactus. Also an alternate proof unicyclic graphs which also reflects structure sets graphs.