A5010781862- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Prenatal Screening and Diagnostics
- Mitochondrial Function and Pathology
- Barrier Structure and Function Studies
- Immune cells in cancer
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- Pelvic and Acetabular Injuries
- Lung Cancer Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Ion Transport and Channel Regulation
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Vagus Nerve Stimulation Research
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Surgical Treatments
- Ureteral procedures and complications
- Congenital Anomalies and Fetal Surgery
Harvard University
2015-2025
Boston Children's Hospital
2020-2025
Jiangsu Province Hospital
2016-2024
Nanjing Medical University
2016-2024
Aarhus University
2024
Sun Yat-sen Memorial Hospital
2021
Sun Yat-sen University
2021
Heilongjiang University of Chinese Medicine
2021
Qingdao Agricultural University
2020
Oxford University Press (United Kingdom)
2020
Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains Alzheimer's disease (AD) patients have been shown experimentally (in absence plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, memory in normal adult rodents. Nevertheless, there has controversy about what types actually confer these AD-like phenotypes. Here, we show that vast majority soluble Aβ species obtained...
Microglial dysfunction is increasingly recognized as a key contributor to the pathogenesis of Alzheimer9s disease (AD). Environmental enrichment (EE) well documented enhance neuronal form and function, but almost nothing known about whether how it alters brain9s innate immune system. Here we found that prolonged exposure naive wild-type mice EE significantly altered microglial density branching complexity in dentate gyrus hippocampus. In injected intraventricularly with soluble Aβ oligomers...
Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neurodevelopment. The mechanisms regulating clearance during postnatal critical period are unclear. Here, we show that K
Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An incomplete understanding this variably progressive condition has hampered the development new therapies beyond serial neurosurgical interventions. Here, we show key role for bidirectional Na-K-Cl cotransporter, NKCC1, in choroid plexus (ChP) mitigate PHH. Mimicking IVH with blood led increased CSF [K+] and triggered cytosolic...
Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate states regulation cerebrospinal fluid (CSF) composition. Here, we developed a platform to analyze diurnal variations in male mouse ChP CSF. Ribosome profiling epithelial cells revealed translatome differences metabolic machinery, secreted proteins, components. Using CSF metabolomics blood-CSF analyses, observed changes metabolites cellular junctions. We then focused on transthyretin (TTR), diurnally...
Environmental enrichment (EE) is a rodent behavioral paradigm that can model the cognitive benefits to humans associated with intellectual activity and exercise. We recently discovered EE's anti-inflammatory protection of brain microglia against soluble oligomers human amyloid β-protein (oAβ). Mechanistically, we report key factor in microglial by EE chronically enhanced β-adrenergic signaling. Quantifying morphology inflammatory RNA profiles revealed mice standard housing (SH) fed agonist...
The neural mechanisms that support the late postnatal development of spatial navigation are currently unknown. We investigated this in rats and found an increase duration AMPAR-mediated synaptic responses hippocampus was related to emergence navigation. More specifically, spontaneous alternation rate, a behavioral indicator hippocampal integrity, increased at end third week association with increases AMPAR response SC-CA1 synapses synaptically driven postsynaptic discharge CA1 pyramidal...
To evaluate the performance of a massively parallel sequencing (MPS)-based test in detecting fetal sex chromosome aneuploidy (SCA) and to present comprehensive clinical counseling protocol for SCA-positive patients.This was retrospective study large patient cohort 5950 singleton pregnancies which underwent MPS-based testing as prenatal screening trisomies 21, 18 13, with X Y chromosomes secondary findings, Southwest Hospital China. women were offered choice knowing whether their SCA results...
Abstract Regulation of the volume and electrolyte composition cerebrospinal fluid (CSF) is vital for brain development function. The Na-K-Cl co-transporter NKCC1 in choroid plexus (ChP) plays key roles regulating CSF by co-transporting ions mediating same-direction water movements. Our previous study showed ChP highly phosphorylated neonatal mice as K + level drastically decreases that overexpression accelerates clearance reduces ventricle size [1]. These data suggest mediates following...
Seizures are due to excessive, synchronous neuronal firing in the brain and characteristic of epilepsy, fourth most prevalent neurological disease. We report handling-induced spontaneous seizures mice deficient for CD39, a cell-surface ATPase highly expressed on microglial cells. CD39-/- with had normal input-output curves paired-pulse ratio measured from hippocampal slices lacked microgliosis, astrogliosis or overt cell loss hippocampus cortex. As expected, however, cerebrospinal fluid...
Peroxisome proliferator-activated receptor-α (PPAR-α) activation has been reported to reduce myocardial ischemia-reperfusion (I/R) injury by inhibiting cell apoptosis. However, the antiapoptotic mechanism of PPAR-α is still unknown. Fenofibrate a agonist In present study, we investigate effects and relevant fenofibrate on experimental in rats.Adult male Wistar rats were pretreated with (80 mg/kg) daily for period 7 days. After treatment period, I/R model was made left anterior descending...
The aim of this study was to analyze the correlation between magnetic resonance imaging-based extramural vascular invasion (EMVI) and prognostic clinical histological parameters stage T3 rectal cancers.Eighty-six patients with cancer who received surgical resection without neoadjuvant therapy were included. Magnetic EMVI scores determined. Correlations pretreatment carcinoembryonic antigen levels, tumor differentiation grade, nodal stage, endothelial growth factor expression analyzed using...
Abstract Reissner’s fiber (RF) is an extracellular polymer comprising the large monomeric protein SCO-spondin (SSPO) secreted by subcommissural organ (SCO) that extends through cerebrospinal fluid (CSF)-filled ventricles into central canal of spinal cord. In zebrafish, RF and CSF-contacting neurons (CSF-cNs) form axial sensory system detects curvature, instructs morphogenesis body axis, enables proper alignment spine. mammalian models, has been implicated in CSF circulation. However,...
Abstract BACKGROUND Amniocentesis is a common procedure, the primary purpose of which to collect cells from fetus allow testing for abnormal chromosomes, altered chromosomal copy number, or small number genes that have single- multibase defects. Here we demonstrate feasibility generating an accurate whole-genome sequence either cellular cell-free DNA (cfDNA) amniotic sample. METHODS cfDNA and isolated cell pellet 31 amniocenteses were sequenced approximately 50× genome coverage by use...
With the speedy development of sequencing technologies, noninvasive prenatal testing (NIPT) has been widely applied in clinical practice for fetal aneuploidy. The cell-free DNA (cffDNA) concentration maternal plasma is most critical parameter this technology because it affects accuracy NIPT-based trisomies 21, 18 and 13. Several approaches have developed to calculate cffDNA fraction total plasma. However, depend on specific single nucleotide polymorphism (SNP) allele information or are...
Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains Alzheimer9s disease (AD) patients have been shown experimentally (in absence plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, memory in normal adult rodents. Nevertheless, there has controversy about what types actually confer these AD-like phenotypes. Here, we show that vast majority soluble Aβ species obtained...