A5056198194- Allergic Rhinitis and Sensitization
- Vaccine Coverage and Hesitancy
- Child Nutrition and Water Access
- Child Abuse and Trauma
- Obstructive Sleep Apnea Research
- Nutritional Studies and Diet
- Early Childhood Education and Development
- Iron Metabolism and Disorders
- Contact Dermatitis and Allergies
- Energy, Environment, and Transportation Policies
- Homelessness and Social Issues
- Study of Mite Species
- SARS-CoV-2 and COVID-19 Research
- Dementia and Cognitive Impairment Research
- vaccines and immunoinformatics approaches
- Gestational Diabetes Research and Management
- Diabetes and associated disorders
- Migration, Health and Trauma
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and preeclampsia studies
- Opioid Use Disorder Treatment
- Attention Deficit Hyperactivity Disorder
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Food Security and Health in Diverse Populations
University of Oxford
2023-2025
Southern Medical University
2025
Changzhi Medical College
2024
Bristol-Myers Squibb (United States)
2024
Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region
2021-2024
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Oxford BioMedica (United Kingdom)
2024
Central South University
2024
National Health and Family Planning Commission
2020-2022
Abstract The rapid global distribution of COVID-19 vaccines, with over a billion doses administered, has been unprecedented. However, in comparison to most identified clinical determinants, the implications individual genetic factors on antibody responses post-COVID-19 vaccination for breakthrough outcomes remain elusive. Here, we conducted population-based study including 357,806 vaccinated participants high-resolution HLA genotyping data, and subset 175,000 serology test results. We...
We aimed to investigate the association of regular opioid use, compared with non-opioid analgesics, incident dementia and neuroimaging outcomes among chronic pain patients.
Background The influence of the safety and security environments on early childhood development (ECD) has been under-explored. Although housing might be linked to ECD by affecting a child’s health parent’s ability provide adequate care, only few studies have examined this factor. We hypothesized that environment is associated with in sub-Saharan Africa (SSA). Methods findings From 92,433 children aged 36 59 months who participated Multiple Indicator Cluster Survey (MICS) 20 SSA countries,...
With great economic development and rapid urbanization in China, left-behind children whose parents migrate to big cities for job has become a large special population which requires more attention. The present study aims explore the specific influence of migrant mothers on early child development, especially social-emotional problems.The data this was obtained from cross-sectional 8 counties central western rural China. Development status 1880 aged <60 months were assessed by Ages & Stages...
Abstract Introduction Sleep fragmentation, linked to increased risks of metabolic and cardiovascular diseases, is often measured using traditional metrics like WASO, SE, ArI, which rely on arbitrary thresholds. While entropy-based methods (e.g., CE, WSE) offer deeper insights, they require complex EEG data are unsuitable for long-term wearable monitoring. This study introduces Temporal Entropy (STE), an biomarker, quantify sleep fragmentation explore its associations with cardiometabolic...
Abstract Study Objectives The association between snoring, a very common condition that increases with age, and dementia risk is controversial. We aimed to investigate the observational causal relationship snoring dementia, elucidate role of body mass index (BMI). Methods Using data from 451 250 participants who were dementia-free at baseline, we examined self-reported incident using Cox proportional-hazards models. Causal Alzheimer’s disease (AD) was bidirectional two-sample Mendelian...
Abstract INTRODUCTION Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation mental health and vascular conditions, neuroimaging outcomes, cognitive function. METHODS Cox proportional‐hazards models were used assess the association between score incident over up 15 years in 1,74,164 participants. Cross‐sectional analyses on dementia‐related outcomes function conducted 39,459 dementia‐free RESULTS was an...
Shortage of cadaveric pancreata and requirement immune suppression are two major obstacles in transplantation therapy type 1 diabetes. Here, we investigate whether i.p. alginate-encapsulated insulin-producing cells from the embryo-derived mouse embryo progenitor-derived insulin-producing-1 (MEPI-1) line could lower hyperglycemia immune-competent, allogeneic diabetic mice. Within days after transplantation, was reversed followed by about 2.5 months normo- to moderate hypoglycemia before...
The "big six" countries (Bangladesh, India, Indonesia, Myanmar, Nepal, and Thailand) in the World Health Organization South-East Asia Region (WHO SEAR) are currently facing severe challenges measles elimination consequent childhood mortality reduction, with inadequacies inequalities coverage of measles-containing-vaccine first-dose (MCV1) being major obstacles. However, these issues inequality MCV1 have not yet been systematically examined. We used data from latest Demographic Surveys...
The aim of the present study was to investigate mechanisms CCAAT/enhancer-binding protein β (C/EBPβ) in cardiac myofibroblast (CMF) differentiation and a rat model fibrosis induced by experimental autoimmune myocarditis (EAM).In vitro studies performed primary neonatal CMF revealed that silencing C/EBPβ expression (via lentiviral mediated shRNA strategies) sufficient reduce mRNA levels as well decrease expressions actin cytoskeletal proteins, cofilin, filamin A (FLNA). TGFβ increased IL-1β,...
Introduction:Effective provider-patient communication has been confirmed to improve diagnosis, treatment planning, health outcomes, patient satisfaction, and compliance.Few studies have measured the effectiveness of between patients rural providers in China.To fill this gap literature, present study describes skills at primary healthcare facilities China investigates provider-and facilitylevel factors underlying these skills. Methods:The standardised successfully completed 504 interactions...
Early intervention of gestational diabetes mellitus (GDM) is effective in reducing pregnancy disorders. Fetal growth, measured by routine ultrasound scan a few weeks earlier before GDM diagnosis, might be useful to identify women at high risk GDM. In the study, generalized estimating equations were applied examine associations between ultrasonic indicators abnormal fetal growth 22–24 and subsequent diagnosis. Of 44,179 deliveries, 8324 (18.8%) diagnosed with 24 28 weeks. At weeks, head...
This cohort study examines patient-reported, multisystem, postacute symptoms among individuals hospitalized with COVID-19 or other lower respiratory tract infections vs those without such hospitalizations during the same period.
Poor child feeding and childhood malnutrition are major public health problems in rural central western China, with little evidence about their environmental determinants. This study aimed to investigate whether household water access is associated dietary diversity nutritional outcomes. We analyzed the cross-sectional data of 3727 children aged 6 59 months applying multivariate linear logistic models estimate effect on children’s anthropometric indices, hemoglobin, diversity. found that...
Neuroinflammation and aberrant immune regulation are increasingly implicated in the pathophysiology of white matter hyperintensities (WMH), an imaging marker cerebrovascular pathologies predictor cognitive impairment. The role human leukocyte antigen (HLA) genes, critical immunoregulation associated with susceptibility to neurodegenerative diseases, WMH remains unexplored.
The associations among maternal depressive symptoms (MDS), mother-child interactions and early child development are poorly understood. This study aimed to explore the role of on between MDS development. A cross-sectional with a multistage sampling method was conducted in rural areas Central Western China. MDS, outcomes (communication, gross motor function, fine problem solving personal social skills) were assessed by Edinburgh Postpartum Depression Scale, Chinese version Ages Stages...
To estimate the prevalence of violent discipline at home against young children, and to explore potential association between multifaceted health risks in children. A community-based cross-sectional survey was conducted twenty rural counties weight provinces western China. The information about child neglect socio-demographic factors, exposure different forms four outcomes collected by face-to-face interview. Before analysis, included interviews were weighted double-weighted comprehensive...