A5101502597- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Cardiac Valve Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Aortic Disease and Treatment Approaches
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Neurogenetic and Muscular Disorders Research
- Thyroid Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Muscle Physiology and Disorders
- Chemokine receptors and signaling
- RNA Research and Splicing
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Diagnosis and Treatment
Zhongshan Hospital of Xiamen University
2021-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Heilongjiang University of Chinese Medicine
2024
China Medical University
2021-2023
First Hospital of China Medical University
2022-2023
Command Hospital
2022
Fujian Medical University
2017-2022
Ministry of Education of the People's Republic of China
2022
Roche (China)
2022
Fujian Provincial Hospital
2017-2020
The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this in normal failing hearts remains unknown. Lactate a crucial energy substrate heart. Here, we identify that α-MHC undergoes lactylation on lysine 1897 to regulate Titin. We observed reduction K1897 mice patients heart failure. Loss K1897R knock-in reduces α-MHC-Titin leads impaired function. Furthermore, identified p300 Sirtuin 1 act as...
Abstract Background Mutations in fibrillin-1 ( FBN1 ) are known to be associated with Marfan syndrome (MFS), an autosomal dominant connective tissue disorder. Most mutations missense or nonsense mutations. Traditional molecular genetic testing for the gene, like Sanger sequencing, may miss disease-causing gene’s regulatory regions non-coding sequences, as well partial complete gene deletions and duplications. Methods Next-generation multiplex ligation-dependent probe amplification gap PCR...
Objective To describe the clinical presentation and novel mutation in ganglioside-beta-galactosidase gene (GLB1) a Chinese family with GM1 gangliosidosis. Methods We collected data from gangliosidosis, performed whole exon sequencing (WES) of proband his parents. The pathogenic sites candidate genes were targeted, detected mutations verified by Sanger sequencing. Enzyme activity β-galactosidase was 293T cells transiently transfected plasmids encoding mutations. Results Two siblings this...
This study aimed to describe the color Doppler flow features of papillary thyroid carcinoma (PTC) and further investigate associations between these lymph node metastasis (LNM). A retrospective analysis clinical data 287 PTC patients confirmed by postoperative pathology at Second Affiliated Hospital Xi'an Jiaotong University from January 2022 April 2023 was conducted. The Adler grading system novel blood patterns were used analyze vascularity lesions on images. Univariate multivariate...
Abstract Objectives The chemokine CXCL1, known as growth-related oncogene α (GRO-α), is a potent chemoattractant and regulator of neutrophils. purpose our study was to evaluate the regulatory response CXCL1 in serum patients with systemic lupus erythematosus (SLE) active stage disease assess whether it implicated pathogenesis/inflammatory process lupus. Methods concentrations were examined 90 SLE patients, 56 other autoimmune diseases (OADs) 100 healthy controls using enzyme-linked...
Abstract Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding effective target therapy is urgent important. WWP2, as one of E3 ubiquitin ligase, involved in many biological processes by specifically binding to substrates. PARP1 plays role cell apoptosis considered therapeutic certain cancers. In this study, we firstly found that WWP2 expressed higher newly diagnosed ALL patients comparing with complete remission (CR) normal control people, relapse than...
Background: Epithelial splicing regulatory proteins (ESRPs) can regulate alternative of RNA and play roles in tumorigenesis development various malignancies. In this study, bioinformatic analyses immunohistochemistry (IHC) were used to investigate the function ESPRs serous ovarian carcinoma (SOC) oncogenesis metastasis. Materials Methods: The mRNA levels ESRPs analyzed by Oncomine gene expression profiling interactive analysis (GEPIA). Prognostic values GEPIA UALCAN website. Genetic...
Diabetes, a multifaceted metabolic disorder, poses significant global health burden with its increasing prevalence and associated complications, such as diabetic nephropathy, retinopathy, cardiomyopathy, angiopathy. Recent studies have highlighted the intricate interplay between N 6 -methyladenosine (m A) non-coding RNAs (ncRNAs) in key pathways implicated these diabetes like cell apoptosis, oxidative stress, inflammation. Thus, understanding mechanistic insights into how m A dysregulation...
To detect potential mutation of immunoglobulin μ -binding protein 2 (IGHMBP2) gene in a two-year-old patient with spinal muscular atrophy respiratory distress type 1 (SMARD1).Genomic DNA was extracted from peripheral blood sample the and her parents, as well cord fetus. Potential mutations coding region IGHMBP2 detected PCR Sanger sequencing.A heterozygous missense c.1060G>A frameshift c.2356delG patient. The were respectively inherited father mother. Neither found derived sample.The...
Long non-coding RNAs (lncRNAs) are widely involved in the pathogenesis of cancers. However, biological roles lncRNAs occurrence and progression colorectal cancer (CRC) remain unclear. The current study aimed to evaluate expression pattern messenger (mRNAs).RNA sequencing (RNA-Seq) CRC tissues adjacent normal from 6 patients was performed functional lncRNA-mRNA co-expression network constructed afterwards. Gene enrichment analysis demonstrated using DAVID 6.8 tool. Reverse transcription...
Abstract Background Mutations in fibrillin 1 ( FBN1 ) are known to be associated with Marfan syndrome (MFS), an autosomal dominant connective tissue disorder. Most mutations missense or nonsense mutations. Conventional molecular genetic testing of using techniques such as Sanger sequencing may miss disease-causing promoter regions other noncoding sequences well partial complete gene deletions and duplications. Methods Two MFS patients referred for were recruited underwent next-generation...
Abstract Acute lymphoblastic leukemia (ALL) has been huge threaten for people health and finding effective target therapy is urgent important. WWP2, as one of E3 ubiquitin ligase, involved in many biological processes by specifically binding to substrates. PARP1 plays a role cell apoptosis considered therapeutic certain cancers. In this study, we firstly tested WWP2 expression patients normal analyzed the relationship with clinicopathologic factors. We demonstrated was ALL knockout...