A5068519221- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- COVID-19 epidemiological studies
- Tryptophan and brain disorders
- RNA modifications and cancer
- RNA regulation and disease
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Skin and Cellular Biology Research
- Cancer, Lipids, and Metabolism
- Neural Networks and Applications
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Genetic factors in colorectal cancer
- Quantum Computing Algorithms and Architecture
- COVID-19 Pandemic Impacts
- Cancer Mechanisms and Therapy
Air Force General Hospital PLA
2025
Chengdu University of Technology
2024
Jilin University
2021-2024
National Institute of Health Sciences
2019-2024
Hebei Medical University
2015-2024
Second Hospital of Hebei Medical University
2019-2024
Soochow University
2023-2024
National University of Singapore
2023
University of Virginia
2021-2022
Affiliated Hospital of Guizhou Medical University
2016-2021
Emerging evidence have illustrated the vital roles of long noncoding RNAs (lncRNAs) in glioma. Nevertheless, majority their and mechanisms gliomagenesis are still largely unclear. In this study, we investigate lncRNA CASC9 on glioma tumourigenesis authenticate its potential mechanisms. Results manifested that was highly expressed specimens cells, moreover, ectopic overexpression correlated with patients' clinic. Functional studies found siRNA-mediated silencing inhibited proliferative...
ABSTRACT Simeprevir (SMV), asunaprevir (ASV), daclatasvir (DCV), and sofosbuvir (SFV), which are newly developed direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) infection, among the key components of anti-HCV regimens. Preclinical studies have identified inhibitory properties for some these DAAs organic anion transporting polypeptide 1B (OATP1B) functions. However, their details remain mostly uncharacterized. Because OATP1B1 OATP1B3 play determinant roles in...
Abstract Mounting evidence suggests the vital roles of long noncoding RNA (lncRNAs) in glioma. However, role LINC00511 gliomagenesis is still uncovered. Here, this study, we aim to investigate effects on glioma cancer phenotype and its deepgoing mechanism. Results indicated that was up‐regulated tissues cell lines, moreover overexpression positively correlated with poor prognosis advanced pathological stages. For upstream regulation, epigenetically by transcription factor specificity protein...
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions people with disease 2019 (COVID-19). While this viral species was unknown prior to January 2020, its similarity other coronaviruses that infect humans allowed for rapid insight into mechanisms it uses human hosts, as well ways immune system can respond. Here, we contextualize SARS-CoV-2 among identify what is known be inferred about behavior once inside a host....
Oligonucleotide therapeutics (OT) have emerged as promising drug modality for various intractable diseases. Recently, liquid chromatography–mass spectrometry (LC-MS) has been commonly employed characterizing and quantifying OT in biological samples. Traditionally, the ion pairing–reverse phase (IP-RP) LC-MS method utilized bioanalyses; however, this approach is associated with several limitations, including memory effect suppression of IP reagents. Therefore, study aimed to develop a new...
Effective systemic therapeutic options are limited for bladder cancer. In this preclinical study we tested whether cancer gene alterations may be predictive of treatment response.We performed genomic profiling two patient derived tumor xenografts (PDX). We optimized the exome sequence analysis method to overcome mouse genome interference.We identified a number somatic mutations, mostly shared by primary tumors and PDX. particular, BLCAb001, which is less responsive cisplatin than BLCAb002,...
We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of liver-type OATP1B3 (Lt-OATP1B3) mRNA, which hepatocyte plasma membrane transporter with broad substrate specificity. However, tissues, both detailed characteristics expression its biological functions remain unclear. With this point mind, we sought to characterize In addition, attempted obtain functional...
After emerging in China late 2019, the novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2) spread worldwide, and as of mid-2021, it remains a significant threat globally. Only few coronaviruses are known to infect humans, only two cause infections similar severity SARS-CoV-2:
Abstract Drug-induced interstitial lung disease (DILD) occurs when drug exposure causes inflammation of the interstitium. DILD can be caused by different types drugs, and some patterns results in a high mortality rate; hence, poses serious problem clinical practice as well development, strategies to diagnose distinguish from other diseases are necessary. We aimed identify novel biomarkers for performing lipidomics analysis on plasma samples patients with acute recovery phase DILD. Having...
The World Health Organization states that early diagnosis is essential to increasing the cure rate for breast cancer, which poses a danger women's health worldwide. However, efficacy and cost limitations of conventional diagnostic techniques increase possibility misdiagnosis. In this work, we present quantum hybrid classical convolutional neural network (QCCNN) based cancer approach with goal utilizing computing's high-dimensional data processing power parallelism efficiency accuracy. When...
Extracellular vesicles (EVs) are cell-derived membrane-bound that important mediators of intercellular communication, and critical orchestrators both physiological pathologic processes. They found in various biological fluids, including serum/plasma, breast milk, urine (Carvalho Oliveira, 2014Carvalho J. Oliveira C. vesicles—powerful markers cancer evolution.Front Immunol. 2014; 5: 685PubMed Google Scholar, Ciardiello et al., 2016Ciardiello Cavallini L. Spinelli Yang Reis-Sobreiro M. de...
Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA is a variant isoform of the liver-type OATP1B3. Because Ct-OATP1B3 shows an excellent cancer-specific expression profile in colorectal cancer (CRC), and that its levels are associated with CRC prognosis, it holds potential to become useful detection diagnosis biomarker. While currently justified only at tissue level, if existence CRC-derived extracellular vesicles (EVs) validated, findings could enhance translational as...
Esophageal cancer related gene-4 (ECRG4) has been shown to be a candidate tumor suppressor in many tumors, but its role glioma remains poorly understood. This study aimed explore whether extracellular vesicles (EVs) derived from brain endothelial cells which overexpressed ECRG4 have anti-tumor effect on gliomas vivo and vitro, as well the possible mechanism. A constructed lentivirus expressing gene was transfected into hCMEC/D3 cell line. The EVs were isolated characterized by Western blot...
Biomarkers that indicate the presence or severity of organ damage caused by diseases and toxicities are useful diagnostic tools. Metabolomics platforms using chromatography coupled with mass spectrometry (MS) have been widely used for biomarker screening. In this study, we aimed to establish a novel metabolomics platform ion MS (IC-MS) human biofluids. We found ethylenediaminetetraacetic acid (EDTA) plasma is not suitable IC-MS because desensitization MS. enabled detection 131 polar...