A5090279568- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Advanced Radiotherapy Techniques
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Reconstructive Surgery and Microvascular Techniques
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advances in Oncology and Radiotherapy
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Autism Spectrum Disorder Research
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Family and Disability Support Research
- Management of metastatic bone disease
- Systemic Sclerosis and Related Diseases
- Dental Health and Care Utilization
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
The University of Texas MD Anderson Cancer Center
2012-2025
Southwest Autism Research & Resource Center
2021-2025
Michigan State University
2024-2025
Michigan United
2025
Grand Rapids Community College
2024
National Institutes of Health
2024
Creative Commons
2023
University of Surrey
2021
Royal Surrey NHS Foundation Trust
2021
University of Kansas Medical Center
2014-2020
Importance Premastectomy radiotherapy (PreMRT) is a new treatment sequence to avoid the adverse effects of on final breast reconstruction while achieving benefits immediate (IMBR). Objective To evaluate outcomes among patients who received PreMRT and regional nodal irradiation (RNI) followed by mastectomy IMBR. Design, Setting, Participants This was phase 2 single-center randomized clinical trial conducted between August 3, 2018, 2, 2022, evaluating feasibility safety RNI (including internal...
Importance Neoadjuvant systemic therapy (NST) has been associated with pathologic complete response (pCR) in up to 60% of breast cancers (BCs). The findings this trial question the necessity surgery. Objective To report preplanned 5-year efficacy outcomes evaluating radiotherapy alone without surgery patients selected image-guided vacuum assisted biopsy (VAB). Design, Setting, and Participants This single-arm, prospective, phase 2 nonrandomized clinical was conducted at 7 US medical centers...
To evaluate toxicity, local control, and survival in anal cancer patients treated with intensity-modulated radiation therapy (IMRT) concurrent chemotherapy.Sixty-five were at a single institution IMRT chemotherapy for localized squamous cell carcinoma of the canal. Radiotherapy was delivered simultaneous integrated boost technique, dose based on T stage. The median to primary tumor pelvis 54 Gy (range, 50 58.8 Gy) 45 40.5 50.4 Gy), respectively. most common regimens 5-fluorouracil cisplatin...
Opinion regarding the optimal plane for prosthetic device placement in breast reconstruction patients has evolved. The purpose of this study was to assess differences complication rates and patient satisfaction between who underwent prepectoral subpectoral implant-based (IBR).The authors conducted a retrospective cohort two-stage IBR at their institution from 2018 2019. Surgical patient-reported outcomes were compared received versus tissue expander.A total 694 reconstructions 481 identified...
This study examined the feasibility and acceptability of a telehealth diagnostic model deployed at an autism center in southwestern United States to safely provide spectrum disorder (ASD) evaluations children, adolescents, adults during COVID-19 pandemic. Participants included all clients for whom evaluation was scheduled clinic (n = 121) over 6-month period. Of 121 clients, 102 (84%) completed evaluation. A determination made 91% (93 out 102) using only procedures. Nine participants (two...
Abstract Purpose Mild breast cancer-related lymphedema (BCRL) is clinically diagnosed as a 5%–10% increase in arm volume, typically measured no earlier than 3–6 months after locoregional treatment. Early BCRL treatment associated with better outcomes, yet amid increasing evidence that exists latent form, delayed until swelling obvious. In this study, we investigated whether near-infrared fluorescence lymphatic imaging (NIRF-LI) surveillance could characterize early onset of peripheral...
Background: MRI-conditional tissue expanders (MRI-CTEs) were developed to address imaging artifacts and challenges in radiation planning associated with traditional (TTEs). This study aims compare the clinical outcomes protocol impacts of MRI-CTEs versus TTEs postmastectomy breast reconstruction. Methods: A retrospective review was conducted on immediate reconstruction or between 2021 2024. Outcomes such as seroma, infection, malposition, expander loss analyzed. Results: total 867 evaluated...
A growing body of research suggests that mindfulness-based interventions may be a valuable method for reducing internalizing symptoms in autistic individuals. The current study extends this work using an effectiveness-implementation hybrid type 1 study. In parallel randomized controlled trial, we examined novel telehealth intervention adolescents and their caregivers. MINDful TIME includes eight weekly group meetings regular use commercially available mindfulness meditation app. Participants...
TPS1120 Background: Breast radiotherapy (RT) is the standard of care for patients with early-stage breast cancer (BC) who undergo breast-conserving surgery (BCS). However, magnitude benefit RT less clear in BCS low-risk disease receive effective systemic therapy. Among HER2-positive (HER2+) BC, 10-year locoregional recurrence has been reported as low 1.5% following BCS, adjuvant chemotherapy and HER2-targeted therapy, RT. Given these exceedingly favorable outcomes, addition HER2-directed we...
Abstract Background Selective omission of sentinel lymph node biopsy (SLNB) in patients with early breast cancer limits surgical morbidity. Adoption this strategy relies on multidisciplinary consensus. Understanding how SLNB influences guideline‐based adjuvant treatment decisions, and the proportion impacted, can help guide decision‐making. Patients methods Data from National Cancer Database (2018–2020) was used to estimate proportions cT1N0 hormone receptor–positive for whom chemotherapy,...
Postmastectomy radiotherapy (PMRT) is associated with altered cosmetic outcomes and higher complication rates in implant-based breast reconstruction (IBR). Conventional wisdom suggests that muscle coverage somewhat protective against PMRT-related complications. In this study, the authors compared surgical patients who underwent two-stage prepectoral versus subpectoral IBR setting of PMRT.
This report describes the rationale, purpose and design of A011801 (CompassHER2 RD), an ongoing prospective, multicenter, Phase III randomized trial. Eligible patients in United States (US) Canada with high-risk (defined as ER-negative and/or node-positive) HER2-positive (HER2+) residual disease (RD) after a predefined course neoadjuvant chemotherapy HER2-directed treatment are 1:1 to adjuvant T-DM1 placebo, versus tucatinib. Patients have also received radiotherapy endocrine therapy, if...
Automatic review of breast plan quality for clinical trials is time-consuming and has some unique challenges due to the lack target contours planning techniques. We propose using an auto-contouring model statistical process control independently assess consistency in retrospective data from a radiotherapy trial.A deep learning was created tested quantitatively qualitatively on 104 post-lumpectomy patients' computed tomography images (nnUNet; train/test: 80/20). The then applied 127 patients...
Patients should have an active role in decisions about pursuing or forgoing specific therapies treatment de-escalation trials.To evaluate longitudinal patient-reported outcomes (PROs) encompassing decisional comfort and health-related quality of life (HRQOL) among patients who elected to enroll a clinical trial evaluating radiotherapy alone, without breast surgery, for invasive cancers with exceptional response neoadjuvant systemic therapy (NST).Prospective, single-group, phase 2 at 7 US...