A5039012941- Microfluidic and Bio-sensing Technologies
- Near-Field Optical Microscopy
- Orbital Angular Momentum in Optics
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Optical Coatings and Gratings
- Advanced MEMS and NEMS Technologies
- Nanoplatforms for cancer theranostics
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- 3D Printing in Biomedical Research
- Digital Holography and Microscopy
- Mechanical and Optical Resonators
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Alzheimer's disease research and treatments
- Molecular Communication and Nanonetworks
- Flow Measurement and Analysis
- Optical Wireless Communication Technologies
- Analytical Chemistry and Chromatography
- Silk-based biomaterials and applications
- Sleep and related disorders
Jilin University
2025
First Hospital of Jilin University
2025
National University of Singapore
2019-2022
Nanyang Technological University
2008-2021
Suzhou Institute of Nano-tech and Nano-bionics
2021
Chinese Academy of Sciences
2021
South China University of Technology
2021
Xiangya Hospital Central South University
2020
Central South University
2020
Anhui University
2019
Abstract Despite intense interests in developing blood measurements of Alzheimer’s disease (AD), the progress has been confounded by limited sensitivity and poor correlation to brain pathology. Here, we present a dedicated analytical platform for measuring different populations circulating amyloid β (Aβ) proteins – exosome-bound vs. unbound directly from blood. The technology, termed mplified p lasmonic ex osome (APEX), leverages situ enzymatic conversion localized optical deposits...
Exosomes are nanoscale vesicles distinguished by characteristic biophysical and biomolecular features; current analytical approaches, however, remain univariate. Here, we develop a dedicated platform for multiparametric exosome analysis-through simultaneous evaluation of the same vesicles-directly in clinical biofluids. Termed templated plasmonics exosomes, technology leverages situ growth gold nanoshells on to achieve multiselectivity. For selectivity, nanoshell formation is tuned...
Optical tweezers are versatile tools capable of sorting microparticles, yet formidable challenges present in the separation nanoparticles smaller than 200 nm. The difficulties arise from controversy on requirement a tightly focused light spot order to create strong optical forces while large area is kept for sorting. To overcome this problem, we near-field potential well array with connected tiny hotspots scale. This situation can sort sizes 100 500 nm, based differentiated energy depths...
Current particle sorting methods such as microfluidics, acoustics, and optics focus on exploiting the differences in mass, size, refractive index, or fluorescence staining. However, there exist formidable challenges for them to sort label-free submicron particles with similar volume index yet distinct shapes. In this work, we report an optofluidic nanophotonic sawtooth array (ONSA) that generates sawtooth-like light fields through coupling, paving physical foundation shape-selective sieving....
Cartilage damage is one of the main causes disability, and 3D bioprinting technology can produce complex structures that are particularly suitable for constructing a customized irregular tissue engineering scaffold cartilage repair. Alginate an attractive biomaterial bioinks because its good biological safety profile fast ionic gelation. However, ionically crosslinked alginate hydrogels recognized as lacking enough mechanical property long-term stability due to ion exchange. Here, we...
Abstract The controlled assembly of nanomaterials into desired architectures presents many opportunities; however, current preparations lack spatial precision and versatility in developing complex nano-architectures. Inspired by the amphiphilic nature surfactants, we develop a facile approach to guide nanomaterial integration – organization distribution metal-organic frameworks (MOFs). Named surfactant tunable architecture (STAR), technology leverages varied interactions surfactants with...
Optofluidic lens with hyperbolic secant index profile, leading to low spherical and field curvature aberrations.
Despite the importance of nucleic acid testing in managing COVID-19 pandemic, current detection approaches remain limited due to their high complexity and extensive processing. Here, we describe a molecular nanotechnology that enables direct sensitive viral RNA targets native clinical samples. The technology, termed catalytic amplification by transition-state switch (CATCH), leverages DNA-enzyme hybrid complexes form switch. By ratiometric tuning its constituents, multicomponent is prepared...
Wheat (Triticum aestivum L.) is one of the three major cereals worldwide. The FusaHum graminearum Sehw., special fugus always damages wheat ear, and produces vomitoxin,is difficult to control prevent, seriously threatens health humans, animals China's food security. Currently, rapidly, accurately non-destructively diagnostic devices or systems for this disease have not been disclosed. In study, infected ears with different severities were picked up in key growth stages. diseased area ear was...
This paper presents the optical fractionation of nanoparticles in silicon waveguide arrays. The lattice is generated by evanescent coupling hotspot size tunable changing refractive index surrounding liquids. In experiment, 0.2-μm and 0.5-μm particles are separated with a recovery rate 95.76%. near-field approach promising candidate for manipulating nanoscale biomolecules anticipated to benefit biomedical applications such as exosome purification, DNA mapping, cell-cell interaction, etc.
This study proposes a suspended thin-film blue light emitting diode (LED) device using backside processing to enhance the performance and extraction efficiency (LEE) of silicon-based GaN LEDs. Photolithography, deep reactive ion etching (DRIE), inductively coupled plasma (ICP) techniques were used completely remove silicon substrate, creating three LEDs with different epitaxial layer thicknesses (5, 4.5, 4 µm). Compared without ICP etching, 5-minute etched LED exhibited superior...
Continuous separation of nano-sized molecules has great importance in biomedical applications. This paper represents a near-field optical approach to separate nanoparticles using speckle patterns. Near-field random light patterns (speckle pattern) are generated by the repeated coupling and interference nano-waveguide arrays. The movements 2-μm 0.5-μm particles studied under co-action Brownian motion exerted force. experimental results show that particle an average lateral displacement 10 μm,...
Correction for ‘Optofluidic lens with low spherical and field curvature aberrations’ by H. T. Zhao <italic>et al.</italic>, <italic>Lab Chip</italic>, 2016, <bold>16</bold>, 1617–1624.