A5047643742- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neurological disorders and treatments
- Prion Diseases and Protein Misfolding
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Advanced Radiotherapy Techniques
- Cerebrospinal fluid and hydrocephalus
- Breast Cancer Treatment Studies
- Neurological diseases and metabolism
- Cerebrovascular and genetic disorders
- Genetics and Neurodevelopmental Disorders
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Genomics and Rare Diseases
- Epilepsy research and treatment
- Frailty in Older Adults
LMU Klinikum
2017-2025
Ludwig-Maximilians-Universität München
2016-2025
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2025
Munich Cluster for Systems Neurology
2022-2024
Universidad de Granada
2024
Friedrich Baur Stiftung
2024
University of Antwerp
2022
KU Leuven
2022
University College London
2019-2022
University of Toronto
2022
<h3>Objective</h3> To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up patients behavioral variant frontotemporal dementia (bvFTD). <h3>Methods</h3> Blood NfL levels from 74 bvFTD, 26 Alzheimer disease (AD), 17 mild cognitive impairment (MCI), 15 healthy controls (Con) at baseline were determined analyzed for diagnostic potential in relation to assessment (Clinical Dementia Rating Scale Sum Boxes [CDR-SOB],...
Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder characterized by deposition of fibrillar aggregates 4R tau-protein in neurons and glial cells the brain. These deposits are key neuropathological finding, allowing diagnosis "definite PSP," which usually established post mortem. To date criteria for clinical PSP vivo do not include biomarkers tau pathology. For intervention trials, it increasingly important to (i) establish an early (ii) develop that correlate with...
Abstract Background Striatal dopamine deficiency and metabolic changes are well‐known phenomena in dementia with Lewy bodies can be quantified vivo by 123 I‐Ioflupane brain single‐photon emission computed tomography of transporter 18 F‐fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill‐understood. Objective We used hitherto largest study cohort combined imaging from European consortium to elucidate role pathophysiological course bodies. Methods compared striatal...
Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types characteristic protein depositions containing either TDP-43 so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. Thalamus cerebellum seem be preferentially affected the pathology unique carriers. Objective: This study aimed determine if carriers showed an enhanced degree thalamic...
Neurodegenerative parkinsonian syndromes comprise a number of disorders that are characterized by similar clinical features but separated on the basis different pathologies, i.e. aggregates α-synuclein or tau protein. Due to overlap signs and symptoms precise differentiation is often difficult, especially early in disease course. Enormous efforts have been taken develop tau-selective PET imaging agents, strong off-target binding MAO-B has observed across first generation ligands....
Abstract Background and purpose Reperfusion treatment in patients presenting with large vessel occlusion (LVO) minor neurological deficits is still a matter of debate. We aimed to compare stroke treated endovascular thrombectomy (EVT) intravenous thrombolysis (IVT) or IVT alone. Methods Patients enrolled the German Stroke Registry–Endovascular Treatment (GSR‐ET) Safe Implementation Treatments Stroke–International Thrombolysis Registry (SITS‐ISTR) between June 2015 December 2019 were...
Abstract C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) provided first insights about a prominent involvement thalamus cerebellum. Our multicenter, 18 F-fluorodeoxyglucose positron-emission tomography study 22 mutation carriers with FTLD, matched non-carriers 23 cognitively healthy controls valuable into functional...
Abstract Background and purpose Acute ischemic stroke due to basilar artery occlusion (BAO) causes the most severe strokes has a poor prognosis. Data regarding efficacy of endovascular thrombectomy in BAO are sparse. Therefore, this study, we performed an analysis therapy patients with routine clinical practice. Methods Patients enrolled between June 2015 December 2019 German Stroke Registry‐Endovascular Treatment (GSR‐ET) were analyzed. Primary outcomes successful reperfusion (modified...
Abstract Purpose Clinical staging in individuals with Alzheimer’s disease (AD) typically relies on neuropsychological testing. Recognizing the imperative for an objective measure of clinical AD staging, regional perfusion early-phase β-amyloid-PET may aid as a cost-efficient index assessment neurodegeneration severity patients disease. Methods Regional deficits well testing (max. 90 days delay) were evaluated 82 biologically defined according to ATN classification. In reference Braak system...
Background: F-18-fluordeoxyglucose positron emission tomography (FDG-PET) is widely used for discriminative diagnosis of tau-positive atypical parkinsonian syndromes (T+APS). This approach now stands to be augmented with more specific tau tracers. Therefore, we retrospectively analyzed a large clinical routine dataset FDG-PET images evaluation the strengths and limitations stand-alone FDG-PET. Methods: A total 117 patients (age 68.4 ± 11.1 y) underwent an exam. Patients were followed...
Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such education are associated with lower dementia risk in general. However, whether more years guards against impact brain alterations also frontotemporal (FTD) has not been shown large patient collective. Therefore, we assessed high performance despite presence [18F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET) hypometabolism FTD. Sixty-six FTD...
In recent years in vivo visualization of tau deposits has become possible with various PET radiotracers. The tracer [18F]PI-2620 proved high affinity both to 3-repeat/4-repeat Alzheimer's disease as well 4-repeat progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). However, be clinically relevant, biomarkers should not only correlate pathological changes but also stage progression. Therefore, we aimed investigate the correlation between topology uptake symptomatology...
Behavioral and neuropsychiatric symptoms are frequent in patients with genetic frontotemporal dementia (FTD). We aimed to describe behavioral phenotypes FTD, quantify their temporal association, investigate regional association brain atrophy.
Many predictive or influencing factors have emerged in investigations of the cognitive reserve model patients with Alzheimer's disease (AD). For example, neuronal injury, which correlates decline AD, can be assessed by [18F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET), structural magnetic resonance imaging (MRI) and total tau cerebrospinal fluid (CSFt-tau), all according to A/T/N-classification. The aim this study was calculate residual performance based on injury biomarkers as...
Approximately 20% of strokes are embolic undetermined source (ESUS). Undetected atrial fibrillation (AF) remains an important cause. Yet, oral anticoagulation in unselected ESUS patients failed secondary stroke prevention. Guidance on effective AF detection is lacking. Here, we introduce a novel, non-invasive risk assessment after ESUS.Catch-Up investigator-initiated, observational cohort study conducted between 2018 and 2019 at the Munich University Hospital. Besides clinical...
Frontotemporal dementia (FTD) is a highly heritable disorder. The majority of genetic cases are caused by autosomal dominant pathogenic variants in the chromosome 9 open reading frame 72 (c9orf72), progranulin (GRN), and microtubule-associated protein tau (MAPT) gene. As motor disorders increasingly recognized as part clinical spectrum, current study aimed to describe phenotypes FTD, quantify their temporal association, investigate regional association with brain atrophy.We analyzed baseline...
Although of high individual and socioeconomic relevance, a reliable prediction model for the prognosis juvenile stroke (18-55 years) is missing. Therefore, study presented in this protocol aims to prospectively validate discriminatory power score 3 months functional outcome after or transient ischemic attack (TIA) that has been derived from an independent retrospective using standard clinical workup data.PREDICT-Juvenile-Stroke multi-centre (n = 4) prospective observational cohort collecting...
Juvenile strokes (< 55 years) account for about 15% of all ischemic strokes. Structured data on clinical outcome in those patients are sparse. Here, we aimed to fill this gap by systematically collecting relevant and modeling a juvenile stroke prediction score the 3-month functional outcome.
Abstract BACKGROUND The baseline criterion for response assessment in IDH-wildtype glioblastoma relies on measuring contrast enhancement, known as ‘measurable disease’ MRI. Recently, criteria based amino acid PET have been proposed clinical trials (PET RANO 1.0 criteria). Here, we compare defined by with the standard MRI-based 2.0 patients newly diagnosed glioblastoma. MATERIAL AND METHODS In this retrospective single-center study, identified who underwent [18F]FET and MRI after resection or...