A5102756821- Functional Brain Connectivity Studies
- Amyotrophic Lateral Sclerosis Research
- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Prion Diseases and Protein Misfolding
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Action Observation and Synchronization
- Advanced Neuroimaging Techniques and Applications
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Spatial Neglect and Hemispheric Dysfunction
- Bioinformatics and Genomic Networks
- Stroke Rehabilitation and Recovery
Universitätsklinikum Würzburg
2013-2025
Social Neuroscience Lab
2014-2023
Landscape Research Group
2023
Authorised Association Consortium
2023
University of Würzburg
2003-2022
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2022
European Neuroendocrine Tumor Society
2021
Forschungsinstitut Technologie und Behinderung
2019
Ludwig-Maximilians-Universität München
2018
Universität Ulm
2017
Objective To investigate the role of neuroinflammation in asymptomatic and symptomatic amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD) mutation carriers. Methods The neuroinflammatory markers chitotriosidase 1 (CHIT1), YKL-40 glial fibrillary acidic protein (GFAP) were measured cerebrospinal fluid (CSF) blood samples from ALS/FTD carriers, sporadic cases controls by ELISA. Results CSF levels CHIT1, GFAP unaffected carriers (n=16). CHIT1 increased gALS (p<0.001, n=65)...
Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect underlying disease mechanisms might help in diagnosis, staging and prediction outcome. We aimed at determining the origin differential diagnostic prognostic potential putative marker microglial activation chitotriosidase (CHIT1).Altogether 316 patients were included, comprising with sporadic ALS, ALS mimics (disease controls (DCo)), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob (CJD), Alzheimer's (AD),...
The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non-conventional translation results in five dipeptide proteins (DPRs), but their clinical utility, overall significance, temporal course the pathogenesis c9ALS/FTD are unclear, although animal models support gain-of-function mechanism. Here, we established poly-GP immunoassay from cerebrospinal fluid (CSF) to identify characterize patients. Significant levels were...
<h3>Objective</h3> To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up patients behavioral variant frontotemporal dementia (bvFTD). <h3>Methods</h3> Blood NfL levels from 74 bvFTD, 26 Alzheimer disease (AD), 17 mild cognitive impairment (MCI), 15 healthy controls (Con) at baseline were determined analyzed for diagnostic potential in relation to assessment (Clinical Dementia Rating Scale Sum Boxes [CDR-SOB],...
Abstract Accurate diagnosis and monitoring of neurodegenerative diseases require reliable biomarkers. Cerebrospinal fluid (CSF) proteins are promising candidates for reflecting brain pathology; however, their diagnostic utility may be compromised by natural variability between individuals, weakening association with disease. Here, we measured the levels 69 pre-selected in cerebrospinal using antibody-based suspension bead array technology a multi-disease cohort 499 individuals disorders...
To assess the utility of serum neurofilament for diagnosis and monitoring primary progressive aphasia (PPA) variants.We investigated light chain (NF-L) levels in blood 99 patients with PPA (40 nonfluent variant [nfvPPA], 38 semantic [svPPA], 21 logopenic [lvPPA]) compared diagnostic performance that reached by CSF NF-L, phosphorylated heavy (pNF-H), β-amyloid (Aβ1-42), tau, tau. The longitudinal change NF-L was measured analyzed correlation functional decline brain atrophy.Serum is increased...
Information on circulating miRNAs in frontotemporal lobar degeneration is very limited and conflicting results have complicated an interpretation Alzheimer's disease thus far. In the present study we I) collected samples from multiple clinical centers across Germany, II) defined 3 homogenous patient groups with high sample sizes (bvFTD n = 48, AD 48 cognitively healthy controls 44), III) compared expression levels both CSF serum IV) detected a set of by using MIQE compliant protocol based...
Abstract Autoimmune encephalitis (AE) can rarely manifest as a predominantly psychiatric syndrome without overt neurological symptoms. This study’s aim was to characterize patients with AE; therefore, anonymized data on suspected AE or isolated syndromes were retrospectively collected. Patients readily detectable symptoms suggestive of (e.g., epileptic seizures) excluded. classified “probable (pAE),” if well-characterized neuronal IgG autoantibodies detected “possible pAE” detection...
Abstract Background Recent data support beta‐synuclein as a blood biomarker to study synaptic degeneration in Alzheimer's disease (AD). Methods We provide detailed comparison of serum immunoprecipitation – mass spectrometry (IP‐MS) with the established markers phosphorylated tau 181 (p‐tau181) (Simoa) and neurofilament light (NfL) (Ella) German FTLD consortium cohort ( n = 374) its relation brain atrophy (magnetic resonance imaging) cognitive scores. Results Serum was increased AD but not...
Abstract Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of causes assessed genotype-driven differences in biomarker profiles, disease severity manifestation by recruiting 509 FTD patients from different centers German FTLD consortium where individuals were including analysis. Exome sequencing as well C9orf72 repeat analysis performed all...
Abstract Introduction The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), semantic (sv), and logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry monitor disease progression. Methods Structural brain an extensive assessment were applied at baseline 4‐year(s) follow‐up in 269 participants. With automated atlas‐based 56 regions assessed. Atrophy progression served calculate sample sizes for therapeutic...
Behavioral variant frontotemporal dementia (bvFTD) is characterized by deep alterations in behavior and personality. Although revised diagnostic criteria agree for executive dysfunction as most characteristic, impairments social cognition are also suggested. The study aimed at identifying those neuropsychological behavioral parameters best discriminating between bvFTD healthy controls. Eighty six patients were diagnosed with possible or probable according to Rascovsky et al. (Brain...
Objectives The hexanucleotide repeat expansion in the C9orf72 gene is most common mutation associated with amyotrophic lateral sclerosis (C9-ALS) and frontotemporal dementia (C9-FTD). Until now, it unknown which factors define whether carriers develop ALS or FTD. Our aim was to identify protein biomarker candidates cerebrospinal fluid (CSF) differentiate between C9-ALS C9-FTD might be indicative for outcome of mutation. Methods We compared CSF proteome 16 8 patients 11 asymptomatic (CAR) by...
Dementia syndromes can be difficult to diagnose. We aimed at building a classifier for multiple dementia using magnetic resonance imaging (MRI). Atlas-based volumetry was performed on T1-weighted MRI data of 426 patients and 51 controls from the multi-centric German Research Consortium Frontotemporal Lobar Degeneration including with behavioral variant frontotemporal dementia, Alzheimer's disease, three subtypes primary progressive aphasia, i.e., semantic, logopenic nonfluent-agrammatic...
Frontotemporal lobar degeneration (FTLD) encompasses behavioral variant frontotemporal dementia (bvFTD), progressive supranuclear palsy, corticobasal syndrome/degeneration, and primary aphasias (PPAs). We cross-validated fluid biomarkers neuroimaging.
Abstract C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) provided first insights about a prominent involvement thalamus cerebellum. Our multicenter, 18 F-fluorodeoxyglucose positron-emission tomography study 22 mutation carriers with FTLD, matched non-carriers 23 cognitively healthy controls valuable into functional...
Abstract Importance The entry of artificial intelligence into medicine is pending. Several methods have been used for the predictions structured neuroimaging data, yet nobody compared them in this context. Objective Multi-class prediction key building computational aid systems differential diagnosis. We support vector machine, random forest, gradient boosting, and deep feed-forward neural networks classification different neurodegenerative syndromes based on structural magnetic resonance...
Takotsubo syndrome (TTS) is a cardiomyopathy that clinically presents as transient and reversible left ventricular wall motion abnormality (LVWMA). Recovery can occur spontaneously within hours or weeks. Studies have shown it mainly affects older people. In particular, there higher prevalence in postmenopausal women. Physical emotional stress factors are widely discussed generally recognized triggers. addition, the hypothalamic-pituitary-adrenal (HPA) axis associated glucocorticoid-dependent...