A5006405333- Fluorine in Organic Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Reactions of Organic Compounds
- Catalytic C–H Functionalization Methods
- Inorganic Fluorides and Related Compounds
- Synthesis and Biological Evaluation
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Lubricants and Their Additives
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Organic Light-Emitting Diodes Research
- Luminescence and Fluorescent Materials
- Tribology and Wear Analysis
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Organic Electronics and Photovoltaics
- Chemical synthesis and alkaloids
- Catalytic Cross-Coupling Reactions
- Liquid Crystal Research Advancements
- Carbohydrate Chemistry and Synthesis
- Microbial Community Ecology and Physiology
- Surfactants and Colloidal Systems
Hainan University
2025
Shanghai University
2015-2024
Shanghai Institute of Organic Chemistry
2007-2023
Chinese Academy of Sciences
2007-2023
Shanghai Innovative Research Center of Traditional Chinese Medicine
2014
A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises addition of an oxidatively generated difluoromethylene to isonitrile functionality subsequent homolytic aromatic substitution. It provides a novel access C-CF2 bond formation.
Cu(ii)-catalyzed aromatic C-H azidation with azido-benziodoxolone under mild conditions has been described. The primary amine exhibits an excellent ortho-directing effect, providing ortho-azidated anilines as the sole products.
An efficient regioselective hydrodifluoromethylation of diverse unactivated vicinal alkenes is described. The primary mechanistic investigations indicate that a CF<sub>2</sub>COOEt radical species involved.
Syntheses, optical, and electrochemical properties of novel C-9 fluorenyl substituted anthracenes linked by a tetrahedral sp(3)-hybridized carbon atom are reported for blue light emitting materials. Remarkably, an unoptimized organic light-emitting diode based on 1-fold fluorene-functionalized anthracene 3 exhibits radiance 4100 cd/m(2) at 12 V maximum EL efficiency 1.36 cd/A with color purity CIE x, y (0.157, 0.082), which is very close to the National Television System Committee standard blue.
A simple and highly efficient Cu-mediated <italic>gem</italic>-difluoromethylenation of a variety aryl boronic acids with bromodifluoromethylated heterocyclic compounds has been disclosed. The transformations were performed in air at room temperature without ligands, bases, or additives.
A copper(0)-promoted direct reductive gem-difluoromethylenation of unactivated aryl or alkenyl halides with benzo-1,3-azolic (oxa-, thia- aza-) difluoromethyl bromides 2-bromodifluoromethyl-1,3-oxazoline has been developed for the construction pharmaceutically important gem-difluoromethylene-linked twin molecules. The unique π-conjugated aryl-fused 1,3-azolic moiety in bromide substrates could stabilise reaction intermediates, which promotes reactivities, providing facile access to...
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been developed. This radical cascade provides a new method for the construction variety gem-difluoromethylenated oxindoles.
A simple Ag I ‐mediated direct difluoromethylation reaction of activated alkenes by using TMSCF 2 COOEt (TMS = trimethylsilyl) under mild conditions has been described. This tolerates a variety functional groups and allows for highly efficient synthesis various difluoro‐containing oxindoles. Mechanistic investigations indicate that difluoromethyl radical initiated the cascade sequence undergoing an addition to alkene.
The first Ag I ‐mediated C–H ethoxycarbonyl difluoromethylation with TMSCF 2 COOEt (TMS = trimethylsilyl) has been developed. radical proceeds smoothly to give the difluoromethylated arenes in moderate high yields Friedel–Crafts‐type regioselectivity. Mechanistic studies indicate that innate through an electrophilic radical‐type pathway.
Manganese-mediated/-catalyzed oxidative carboazidation of acrylamides was developed for the synthesis various azido oxindoles.
An efficient method for the synthesis of thermally stable and pharmaceutically important gem-difluoromethylene azo compounds is developed. This protocol achieved gem-difluoromethylenation nitrogen center arenediazonium salts through in situ generated benzo-1,3-diazolic difluoromethylene radical addition to under mild Ag-initiated conditions.
Chiral bifunctional <italic>N</italic>-prolyl sulfinamide and its TFA salts were synthesized applied in asymmetric aldol reactions under solvent-free conditions. The adducts obtained with high to excellent yields, enantioselectivities diastereoselectivities. A matching effect between chiral proline moieties was observed for the catalysts.
Copper-catalyzed <italic>gem</italic>-difluoromethylenation of the C(sp<sup>2</sup>)–H bonds alkenes has been developed. This protocol is first to efficiently achieve unactivated aliphatic terminal olefins and applied in <italic>gem</italic>-difluoromethylenation/cyclization alkenes.
An Ag I ‐mediated ethoxycarbonyldifluoromethylation of isocyanides has been developed. This radical cascade reaction involves the addition difluoromethylene to isocyanide functionality, and subsequent homolytic aromatic substitution give difluoromethylated phenanthridines with a good functional‐group tolerance.
An efficient <italic>gem</italic>-difluoromethylenation of benzyl bromides through copper-mediated direct radical/radical C–C cross-coupling has been developed for the construction CH<sub>2</sub>–CF<sub>2</sub> linkage.
A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence PPh3, CCl4, and NEt3 furnished formation N-acyl indolines good to excellent yields. This new approach provides an efficient, scalable, low-cost, direct access biologically important which are further oxidizable indoles oxindoles.