A5010792428- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Cancer Genomics and Diagnostics
- Ovarian function and disorders
- 3D Printing in Biomedical Research
- Sperm and Testicular Function
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Health, Environment, Cognitive Aging
- Tissue Engineering and Regenerative Medicine
- Bioinformatics and Genomic Networks
- Reproductive Health and Technologies
- Cell Image Analysis Techniques
- Culinary Culture and Tourism
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Molecular Biology Techniques and Applications
- Nutrition, Genetics, and Disease
- Gene expression and cancer classification
- Biomedical Text Mining and Ontologies
- Melanoma and MAPK Pathways
- Genetics, Bioinformatics, and Biomedical Research
Northwestern University
2018-2025
Lurie Children's Hospital
2022-2024
Comer Children's Hospital
2023
York University
2022-2023
Northwestern Medicine
2022
Duke University
2017
Abstract Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of patients with triple-negative breast representative patient-derived xenograft models. Using intravital multiphoton microscopic imaging, we found that clustered in migration circulation resulted from aggregation individual rather collective cohesive shedding. Aggregated...
Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma, suggesting that durable control of will be a challenge. By combining statistical modeling genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation >20 vitro vivo models, we discovered major converge activate the transcription factor, c-MYC (MYC). MYC expression pathway gene signatures were suppressed following drug treatment, then rebounded during progression....
While ovarian tissue cryopreservation (OTC) is an important fertility preservation option, it has its limitations. Improving OTC and transplantation (OTT) must include extending the function of reimplanted by reducing extensive activation primordial follicles (PMFs) eliminating risk reimplanting malignant cells. To develop a more effective OTT, we understand effects microenvironment on folliculogenesis. Here, describe method for producing decellularized extracellular matrix (dECM) hydrogels...
Dear editor, The ovary is a dynamic organ, broadly divided into anatomical structures that include the outer cortex, inner medulla, and hilum (Figure 1A B). In addition to general proximity, these regions contain unique constituents, with differences in prevalence of certain follicle stages, relative densities, blood vessels, cell types corresponding functional between [1]. addition, range development, thickness, cellular composition based on an individual's pubertal status, menstrual cycle...
Abstract Children diagnosed with cancer today can expect a greater than 80% chance of 5-year survival. Childhood survivors are significantly more likely to be infertile or have difficulty getting pregnant their siblings. Studies shown that infertility is one the primary concerns survivors. Fertility preservation (FP) completed before treatment starts gives patient best fertility potential for biological child in future. Infertility significant risk factor those treated gonadotoxic therapy...
<p>Supplementary Figures S1-S9</p>
<div>Abstract<p>Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of patients with triple-negative breast representative patient-derived xenograft models. Using intravital multiphoton microscopic imaging, we found that clustered in migration circulation resulted from aggregation individual rather collective cohesive...
<p>Supplementary Figures S1-S9</p>
<p>List of Videos S1-8 Tables S1-7 and Methods</p>
<div>Abstract<p>Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of patients with triple-negative breast representative patient-derived xenograft models. Using intravital multiphoton microscopic imaging, we found that clustered in migration circulation resulted from aggregation individual rather collective cohesive...
<p>Supplementary videos (autoplay) in ppt</p>
<p>Supplementary videos (autoplay) in ppt</p>
<p>List of Videos S1-8 Tables S1-7 and Methods</p>
Purpose: This protocol describes the procedure for cryopreservation of organ donor derived human ovarian tissue via slow freeze with a semi-automated controlled rate freezer in research setting.
Abstract Disclosure: E. Tsui: None. M.M. Laronda: Follicles, the functional unit of ovary with potential to develop into mature eggs, are composed a single germ cell and somatic support cells (i.e., granulosa theca cells). While animal studies have demonstrated positive effect ovarian stromal follicle development, compartment remains largely undescribed. Moreover, egg quality is maximized after pubertal transition, but impact puberty on their influence not well understood. To elucidate...
Offering a glimpse into the Chinese-diasporic experience, I create mundane artworks that elicit sensation of reliving small joys from my life. In 饺子, or dumpling, in English, still life drawing home-made Chinese pork dumpling is captioned with word “dumpies!”. The image references time when siblings and were trying to remember what food called Mandarin (none us are remotely good at language) and, failed, we settled on calling them dumpies instead. vast negative space resonates simple design...