A5027642382- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Emergency and Acute Care Studies
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Antibiotic Use and Resistance
- Healthcare Operations and Scheduling Optimization
- Urticaria and Related Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Restraint-Related Deaths
- Anesthesia and Sedative Agents
- Cardiac and Coronary Surgery Techniques
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Congenital Heart Disease Studies
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Technology and Patient Monitoring
- Pneumothorax, Barotrauma, Emphysema
Yokohama City University Hospital
2015-2024
Yokohama City University
2013-2024
Intensive Care Society
2016
National Heart Institute
2012
Kumamoto University
1991-1993
The University of Tokyo
1993
The murine interleukin 5 receptor (mIL-5R) is composed of two distinct subunits, alpha and beta. subunit (mIL-5R alpha) specifically binds IL-5 with low affinity. beta beta) does not bind by itself, but forms the high-affinity mIL-5R alpha. has been revealed to be mIL-3R-like protein, AIC2B which shared receptors for IL-3 granulocyte/macrophage colony-stimulating factor. We demonstrated here reconstitution functional human on mouse IL-2-dependent cell line, CTLL-2. CTLL-2 was transfected...
We report a young cardiac surgery patient who developed severe aspiration pneumonia due to postoperative nausea and vomiting (PONV) despite prophylactic therapeutic administration of multiple antiemetic agents. A 19-year-old woman underwent corrective for partial anomalous pulmonary venous connection. On day (POD) 1, she was extubated after receiving dexamethasone (6.6 mg), droperidol (1 granisetron mg) PONV prophylaxis. Despite metoclopramide, persisted. POD 2, followed massive vomiting,...
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Abstract Background The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model is widely used to predict mortality in Japanese intensive care units (ICUs). Although the model’s discrimination excellent, its calibration poor. APACHE overestimates risk of death, making evaluation healthcare quality inaccurate. This study aimed improve develop a Japan Risk Death (JROD) for benchmarking purposes. Methods A retrospective analysis was conducted using national clinical registry ICU...
OBJECTIVESAcute kidney injury is common following cardiac surgery. Experimental models of acute suggest that successful therapy should be implemented within 24–48 h renal injury. However, it difficult to detect shortly after surgery, because creatinine concentration diluted by cardiopulmonary bypass. We hypothesized that, bypass, reduction ratios would correlate with haematocrit and associated the incidence
Abstract Purpose Older adults admitted to the intensive care unit (ICU) usually have fair baseline functional capacity, yet their age and frailty may compromise management. We compared characteristics management of older (≥ 75 years) versus younger hospitalized in ICU with hospital-acquired bloodstream infection (HA-BSI). Methods Nested cohort study within EUROBACT-2 database, a multinational prospective including 18 during 2019–2021. terms (clinical signs symptoms, source, microbiological...
Summary The interleukin‐5 receptor α chain (IL‐5Rα) is known to regulate the development and function of B cells eosinophils. Although functions IL‐5Rα cytoplasmic domain subregions have been studied extensively using cultured cell lines, this approach has limitations when studying distinct primary B‐cell subpopulations their responsiveness IL‐5. In present study, we generated mice on an null background, each expressing a mutant form transgene ligated µ enhancer VH promoter, either lacking...
The rapid shallow breathing index (RSBI) is used clinically to help predict a patient's likelihood of successful liberation from mechanical ventilation (MV). However, the traditional threshold (<105 breaths/min/L) may underperform in patients with chronic obstructive pulmonary disease (COPD). We sought determine optimal RSBI for COPD improve diagnostic accuracy predicting ventilator liberation.This was prospective observational multicenter study [according Global initiative Chronic...
Abstract Aim This study observed changes in respiratory rate measurement (RRM) and identified barriers challenges clinical practice that influence healthcare worker behaviour, aiming to improve RRM a hospital setting. Design An observational was conducted. Methods We analysed the behaviour of workers at where multi‐nudges were introduced RRM. Results checked respiration using electronic data discovered original rates low. Measurement rapidly increased after posters added. Barriers such as...
The aim of this study was to reveal the effect anesthesiologist's mental workload during induction general anesthesia. Twenty-two participants were categorized into anesthesiology residents (RA group, n = 13) and board certified anesthesiologists (CA 9). Subjects participated in three simulated scenarios (scenario A: baseline, scenario B: simple addition tasks, C: combination tasks treatment unexpected arrhythmia). We used two-digit integer additions every 5 seconds as a secondary task. Four...
The high affinity IL-5R consists of at least two chains, alpha and beta. binds IL-5 with low affinity. beta is required to construct the IL-5R, although does not bind by itself. To characterize roles on association, dissociation, internalization IL-5, we compared binding kinetics 35S-labeled (dissociation constant approximately 150 pM) bearing T88-M those 30 nM) MOPC104E. We found that association either natural receptor were similar. maximal both was rapid (within 10 min). dissociation from...
<h3>BACKGROUND:</h3> During sedation for upper gastrointestinal endoscopy, oxygen delivery via a nasal cannula is often necessary. However, the influences of route and breathing pattern on F<sub>IO<sub>2</sub></sub> have not been thoroughly investigated. The aim this simulation study was to investigate difference in with pharyngeal versus during high- or low-tidal volume (V<sub>T</sub>) ventilation open- closed-mouth breathing. <h3>METHODS:</h3> Six healthy volunteers were asked breathe...
Capnometry detects hypoventilation earlier than pulse oximetry while supplemental oxygen is being administered. We compared the end-tidal CO2 (PETCO2 ) measured using a newly developed nasal cannula with CO2-sampling port and PaCO2 in extubated subjects after abdominal surgery. also investigated whether difference between PETCO2 affected by resting, spontaneous breathing mouth consciously closed, deep closed.Adult post-abdominal surgery admitted to ICU were enrolled. After extubation, was...
Background: Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is known as a prolonged immunodeficiency that occurs after severe infection. Few studies have demonstrated direct relationship between PIICS physical dysfunction in post-intensive care (PICS). We herein investigated how each component of PICS was affected by the diagnosis during hospitalization examined using assessments performed at Hitachi General Hospital Clinic. Methods: The 273 patients who visited...
Acute kidney injury (AKI) after cardiac surgery is a common complication that can lead to death. We previously reported the creatinine reduction ratio (CRR) serves as useful prognostic factor for AKI. The primary objective of this study was determine predictors AKI surgery. secondary reliability CRR short- and long-term outcomes. retrospectively collected information about patients who underwent cardiopulmonary bypass. Patients were divided into non-AKI groups based on AKIN RIFLE criteria....
A "cannot-ventilate, cannot-intubate" situation is critical. In difficult airway management, transtracheal jet ventilation (TTJV) has been recommended as an invasive procedure, but specialized equipment required. However, the influence of upper resistance (UAR) during TTJV not clarified. The aim this study was to compare using a manual ventilator (MJV) and oxygen flush device anesthetic machine (AM). We made model lung offering variable UAR by adjustment tracheal tube size that can ventilate...
<h3>BACKGROUND:</h3> For early detection of respiratory and hemodynamic changes during anesthesia, continuous end-tidal carbon dioxide concentration (P<sub>ETCO<sub>2</sub></sub>) is monitored by capnometry. However, the accuracy CO<sub>2</sub> monitoring spontaneous breathing in extubated patients remains undetermined. Therefore, we aimed to compare P<sub>ETCO<sub>2</sub></sub> measured capnometry using an oxygen mask with a sampling port (capnometry-type mask) P<sub>CO<sub>2</sub></sub>...
High-flow nasal canulae (HFNC) deliver high-flow humidified gas at up to 60 l/minute. There are two types of respiratory circuit generate mix flow, Blender type (typeB) and Venturi (typeV). The therapy is well established in the pediatric population HFNC use has been described adult population. It reported that provide higher FIO2 compared with low-flow canulae, also create mild positive pharyngeal airway pressure, but effect on alveolar pressure unknown. We aimed investigate by measuring...