A5011353980- Metal complexes synthesis and properties
- Radiopharmaceutical Chemistry and Applications
- Click Chemistry and Applications
- Glioma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- CAR-T cell therapy research
- Virus-based gene therapy research
- Cancer-related cognitive impairment studies
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Brain Metastases and Treatment
- Photoacoustic and Ultrasonic Imaging
- Intensive Care Unit Cognitive Disorders
- Immunotherapy and Immune Responses
- Venous Thromboembolism Diagnosis and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer survivorship and care
- Tryptophan and brain disorders
- Angiogenesis and VEGF in Cancer
- Adrenal and Paraganglionic Tumors
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Palliative Care and End-of-Life Issues
- Advanced biosensing and bioanalysis techniques
Northwestern University
2016-2025
Midwestern University
2024-2025
Neurological Surgery
2019-2024
Northwestern Medicine
2018-2024
Northwestern University
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2022-2023
Johns Hopkins University
2022
Johns Hopkins Medicine
2022
Northwestern Memorial Hospital
2020-2021
Lewis University
2019
Abstract Given the marginal penetration of most drugs across blood-brain barrier, efficacy various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microbubbles (MB) to open barrier increase concentration liposomal doxorubicin PD-1 blocking antibodies (aPD-1). We report results on a cohort 4 GBM patients preclinical models treated with this approach. LIPU/MB increases by 2-fold 3.9-fold in human murine brains...
Object. In this retrospective study the authors examined aspect ratio (AR; maximum dimension of dome/width neck an aneurysm) and compared distribution in a group ruptured unruptured aneurysms. A similar comparison was performed relation to aneurysm alone. The sought evaluate utility these measures for differentiating Methods. Measurements were made 774 aneurysms 532 patients at three medical centers. One hundred twenty-seven harbored only lesions, 290 115 both lesions. Cases included if...
Abstract Background Veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy in recurrent glioblastoma (rGBM) was reported to show tumor infiltration of CD8+ T cells, encouraging survival, but also up-regulation immune checkpoint signaling, providing the rationale for a combination trial with inhibition. Methods An open-label, multi-institutional, dose-escalation phase I rGBM subjects (NCT03636477) accrued 21 3 dose-escalating cohorts: (1) neoadjuvant then ongoing nivolumab (1mg/kg)...
Abstract Background Glioblastoma is a highly aggressive brain cancer that resistant to conventional immunotherapy strategies. Botensilimab, an Fc-enhanced anti-CTLA-4 antibody (FcE-aCTLA-4), has shown durable activity in “cold” and immunotherapy-refractory cancers. Methods We evaluated the efficacy immune microenvironment phenotype of mouse analogue FcE-aCTLA-4 treatment-refractory preclinical models glioblastoma, both as monotherapy combination with doxorubicin delivered via low-intensity...
RNA sequencing of cerebral hematoma myeloid cells reveals a two-stage functional and metabolic program associated with recovery.
Abstract BACKGROUND A simple, reliable grading scale to better characterize nonfunctioning pituitary adenomas (NFPAs) preoperatively has potential for research and clinical applications. OBJECTIVE To develop a from prospective multicenter cohort of patients that accurately reliably predicts the likelihood gross total resection (GTR) after transsphenoidal NFPA surgery. METHODS Extent-of-resection (EOR) data study in surgery were analyzed (TRANSSPHER study; ClinicalTrials.gov NCT02357498)....
Background Critical illness may weaken muscles, with long-term consequences. Objective To assess physiological responses to an early standardized passive exercise protocol prevent muscle weakness in adults receiving mechanical ventilation. Methods A quasi-experimental within-subjects repeated-measures design was used. Within 72 hours of intubation, 30 patients had 20 minutes bilateral leg movement delivered by continuous-passive-motion machines at a rate and flexion-extension. Heart rate,...
Glioblastoma (GBM) is the most common and aggressive form of malignant glioma in adults with a median overall survival (OS) time 16-18 months age diagnosis at 64 years old. Recent work has suggested that depression psychosocial distress are associated worse outcomes patients GBM. We therefore hypothesized targeted neutralization selective serotonin reuptake inhibitor (SSRI) antidepressant treatment would be longer OS among To address this hypothesis, we retrospectively studied association...
Glioblastoma (GBM) is the most lethal primary brain tumor in adults. No treatment provides durable relief for vast majority of GBM patients. In this study, we've tested a bispecific antibody comprised single-chain variable fragments (scFvs) against T cell CD3ε and interleukin 13 receptor alpha 2 (IL13Rα2). We demonstrate that engager (BiTE) (BiTELLON) engages peripheral tumor-infiltrating lymphocytes harvested from patients' tumors and, so doing, exerts anti-GBM activity ex vivo. The...
Survival alone is no longer an adequate outcome for persons with brain tumors; the quality of survivorship experience should be viewed equal importance. Symptom management a significant component care. Regardless their histology, tumors and therapies used to treat them produce symptoms that affect individual's ability function in everyday life. Common include fatigue, cognitive impairment, distress, sleep disturbance. Symptom-based interventions focus on prevention, self-management,...
Abstract Background The blood-brain barrier (BBB) impedes the passage of most circulating drugs into brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens BBB, improving parenchymal drug penetration. Parenchymal permanence upon short-lived BBB opening is unknown. We compared temozolomide, carboplatin, and fluorescein, investigated effect LIPU/MB on concentration carboplatin fluorescein. Methods analyzed four patients who underwent intraoperative intravenous...
Abstract While chimeric antigen receptor (CAR) T-cell therapies present novel therapeutic opportunities, their clinical success has been limited when targeting malignant brain tumors, such as gliomas. Marked antigenic heterogeneity of those tumors underlies treatment resistance. Ultimately, it is crucial to promote endogenous T cell responses against tumor cells not targeted by the CAR (“epitope-spreading”). However, natural anatomical barriers and an immunosuppressive environment allow...
Increased age is a strong and unfavorable prognostic factor for patients with glioblastoma (GBM). However, the relationships between stratified patient age, comorbidities, medications have yet to be explored in GBM survival analyses. To evaluate co-morbid conditions, tumor-related symptoms, medication prescriptions, subject establish potential targets prospective studies. Electronic health records 565 IDHwt were evaluated at single center January 1, 2000 August 9, 2021 retrospectively...
Abstract Background Tumor Treating Fields (TTFields) Therapy is an FDA-approved therapy in the first line and recurrent setting for glioblastoma. Despite Phase 3 evidence showing improved survival with TTFields, it not uniformly utilized. We aimed to examine patient clinician views of TTFields factors shaping utilization through a unique research partnership medical neuro oncology social sciences. Methods Adult glioblastoma patients who were offered at tertiary care academic hospital invited...
Abstract Purpose: Paclitaxel (PTX) is one of the most potent and commonly used chemotherapies for breast pancreatic cancer. Several ongoing clinical trials are investigating means enhancing delivery PTX across blood–brain barrier glioblastomas. Despite widespread use cancer, initiative to repurpose this drug gliomas, there no predictive biomarkers inform which patients will likely benefit from therapy. Experimental Design: To identify susceptibility PTX, we performed a genome-wide CRISPR...