A5101607177- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Cancer Genomics and Diagnostics
- Calpain Protease Function and Regulation
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Dermatology and Skin Diseases
- Signaling Pathways in Disease
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Technology and Data Analysis
- Innovation in Digital Healthcare Systems
- Venomous Animal Envenomation and Studies
- Dermatologic Treatments and Research
- Transgenic Plants and Applications
- Urticaria and Related Conditions
- Pharmacy and Medical Practices
- Effects of Radiation Exposure
- S100 Proteins and Annexins
- TGF-β signaling in diseases
- Synthesis of heterocyclic compounds
- Heat shock proteins research
- RNA regulation and disease
- Adrenal Hormones and Disorders
- Biomedical Ethics and Regulation
Indiana University – Purdue University Indianapolis
1997-2022
Indiana University School of Medicine
2020
Central South University
2017-2020
Richard L. Roudebush VA Medical Center
2020
University of Indianapolis
2011-2019
The University of Sydney
2014
Soochow University
2006
Heat shock protein 90α (HSP90α) maintains cell stabilization and regulates death, respectively. Recent studies have shown that HSP90α is involved in receptor interacting 3 (RIP3)‐mediated necroptosis HT29 cells. It known oxygen glucose deprivation (OGD) can induce necroptosis, which regulated by RIP3 neurons. However, it still unclear whether participates the process of OGD‐induced cultured neurons via regulation RIP3. Our study found occurs primary cortical PC‐12 cells following exposure to...
The purpose of the current study was to investigate whether peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) can interact with calpastatin (CAST) and regulate CAST/calpain2, under excessive glutamate conditions, subsequently necrosis in rat retinal neurons. Glutamate triggered CAST/calpain2-mediated regulation primary cultured neurons, as demonstrated by propidium iodide-staining lactate dehydrogenase assay. Co-IP results a computer simulation suggested that Pin1 could bind...
Signal transducer and activator of transcription 3 (Stat3) is a member the Stat family proteins involved in signaling many different cell types, including osteocytes. Osteocytes are considered major mechanosensing cells bone due to their intricate dendritic networks able sense changes physical force orchestrate response osteoclasts osteoblasts. We examined role Stat3 osteocytes by generating mice lacking these using Dmp-1(8kb)-Cre promoter (Stat3cKO mice). Compared age-matched littermate...
In our previous study, we reported that peptidyl-prolyl isomerase 1 (Pin1)-modulated regulated necrosis (RN) occurred in cultured retinal neurons after glutamate injury. the current investigated role of calcium/calmodulin-dependent protein kinase II (CaMKII) Pin1-modulated RN rat neurons, and an animal vivo model. We first demonstrated might lead to calcium overloading mainly through ionotropic receptors activation. Furthermore, CaMKII activation induced by overloaded leads Pin1 subsequent...
Advanced osteosarcoma (OS) is usually treated by preoperative and postoperative chemotherapy, but there are a very limited number of active agents. Celecoxib (Cel) COX-2-selective nonsteroidal anti-inflammatory drug its antitumoral effect has been shown widely in variety cancers including OS cells vitro. However, the potential combinational Cel with other biological therapy not reported cells. In this study, effects Cel, miR-34a mimics, their combination on cell proliferation (MTT assay),...
Many studies on retinal injury and repair following elevated intraocular pressure suggest that the survival ratio of neurons has been improved by various measures. However, visual function recovery is far lower than expected. The homeostasis synapses in signal pathway key structural basis for delivery signals. Our previous found complicated changes synaptic structure between occurred much earlier obvious degeneration ganglion cells rat retinae. lack consideration these rescue strategy may be...
In the past 10 years, clinical biobanks have experienced increasing expansion in China. Demand for systematically educated biobanking professionals is a priority Chinese biobanks' agenda. The cryobiology and biobankology course first semester-long China, designed developed at Central South University with international cooperation. Leading professors were from United States, Kingdom, Canada to teach latest version of knowledge skills around globe. This comprehensive elective six specific...
In this paper we consider a change-point model which consists of two change points and transition period in between. A nonparametric estimation procedure for the unknown is proposed, based on weighted Kolmogorov-Smirnov norm. The strong consistency resulting estimates shown along with rate convergence. Detailed technical proofs main results are given as well simulation study. exemplified well-known Coal-Mining data.
We have explored a better method to preserve and store human medically amputated large size samples. The approach involved developing special embalming solution procedures for biopreservation biostorage of large-sized sample as whole specimen rather than dissected small parts. Evaluation the effect our on extremities compared with excised tissues was conducted. Histological morphological techniques elemental analyses were utilized assess effects new using solution.Whole remains (skin,...
Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead multiple side effects including GC induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation causing effects.