A5073542347- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Neurofibromatosis and Schwannoma Cases
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- interferon and immune responses
- Kruppel-like factors research
- Case Reports on Hematomas
- Medical Imaging Techniques and Applications
- Heat shock proteins research
- Cellular Mechanics and Interactions
- Galectins and Cancer Biology
- Neuroblastoma Research and Treatments
- Congenital heart defects research
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- 14-3-3 protein interactions
Tianjin Medical University General Hospital
2012-2025
Singapore General Hospital
2016
National University of Singapore
2016
Tianjin Medical University
2011-2013
Abstract Glioblastomas (GBMs) are the most prevalent and devastating primary intracranial malignancies have extensive heterogeneity. Notch1 signaling is a more complex process in development of numerous cell tissue types, including gliomagenesis progression, upregulated glioma-initiating cells. However, contradictory expression among lower grade gliomas GBMs confounds our understanding GBM biology has made identifying effective therapies difficult. In this study, we validated that NF-κB(p65)...
Abstract Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity mortality. TMEM158 been reported to promote progression of solid tumors. However, its potential role glioma still unclear. Here, we found that expression human cells core was significantly higher than noncancerous at edge using bioinformatics analysis. Cancer patients with GBMs harbored those WHO grade II or III gliomas. Interestingly, regardless grading, samples were IDH1-wild-type...
Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability self-renew, differentiate into heterogeneous types tumor cells, sustain tumorigenicity; thus, GICs lead recurrence. Accumulating evidence indicates autophagy can induce stem cell differentiation increase lethality temozolomide against GICs. However, mechanism underlying regulation GIC self-renewal by...
Glioblastoma is the most common and lethal primary intracranial tumor. As key regulator of tumor cell volume, sodium‐potassium‐chloride cotransporter 1 (NKCC1) expression increases along with malignancy glioma, NKCC1 has been implicated in glioblastoma invasion. However, little known about role epithelial‐mesenchymal transition‐like process gliomas. We noticed that aberrantly elevated leads to changes shape, polarity, adhesion cells glioma. Here, we investigated whether promotes an...
Abstract In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune‐like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin‐9, a ligand for T‐cell immunoglobulin mucin 3, has shed new light treatment of malignant glioma. potential mechanism Galectin‐9 is still under discussion. this study, first, we methodically gathered 1,027 patients with RNA‐seq and 986 survival data to...
ABSTRACT Background Glioma stem cells (GSCs) contribute to the initiation, recurrence, metastasis, and drug resistance of glioblastoma multiforme (GBM). Long noncoding RNAs (lncRNAs) are critical modulators in development progression GBM; however, specific lncRNAs related GSCs remain largely unexplored. This study aims identify dysregulated GSCs, unravel their contributions GBM progression, propose new targets for diagnosis treatment. Methods GeneChip analysis was utilized GSCs. The...
Glioma is still an incurable disease with high invasiveness. Heat shock 70 kDa protein 4 (HSPA4) a member of the HSP110 family, and associated development progression various cancers. In current study, we assessed expression HSPA4 in clinical samples, found that was up-regulated glioma tissues correlated tumor recurrence grade. Survival analyses demonstrated patients had lower overall survival disease-free times. vitro knockdown inhibited cell proliferation, mediated cycle arrest at G2 phase...
Background/Aims: Jagged1 is the ligands of Notch signaling and has been shown to promote glioma-initiating cells (GICs) in glioblastoma. The role GICs invasion underlying molecular mechanisms remain unclear. Methods: Survival data from R2 genomics analysis, Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA) visualization platform database were used evaluate effects on overall patient survival. we investigated induced cells’ by matrix degradation assays Transwell cell vitro, then further...
Ca2+ release-activated channels (CRAC) are the main entry pathway regulating intracellular concentration in a variety of cancer types. Orai2 is pore-forming subunit CRAC central neurons. To explore role glioblastoma (GBM), we investigated key pathways and genes Orai2-mediated GBM by bioinformatic analyses. Via The Cancer Genome Atlas (TCGA), French, Sun, Gene Expression Omnibus (GEO) (GDS3885) datasets, collected 1231 cases with RNA-seq data analyzed functional annotation gene ontology (GO)...
To investigate the utility of hMena, a family enabled/vasodilator-stimulated phosphoprotein (Ena/VASP), we sought to characterize expression profile and distribution characteristics hMena in large panel glioma samples determine whether levels might correlate with pathological grade glioma.Sixty-five specimens different grades five control brain tissues were collected. In 6 21 glioblastoma patients, multi-specimens obtained respectively from main tumor mass, junction zone between normal...
The investigation and development of recently introduced agents or radiological measurements caused emergent misunderstandings to the response assessment glioma. To date, classical Macdonald criteria neuro-oncology (RANO) have been used successively for evaluation glioma outcome. However, ongoing efforts on complementary assessments are necessary combat this malignancy. In review, we highlight shortcomings current introduce initiative effort RANO guideline its offspring. We also discuss some...
Objective To explore the role of Rac1 in migration and invasion glioma stem cells (GSCs) by decreasing activity with specific Rac 1 inhibitor.Methods U251 were cultured serum-free DMEM/F12 cell medium,and isolation CD133+ (GSCs)from was performed; immunofluorescence conducted to identify GSCs.Racl assay employed detect CD133-cells; detected Transwell migration/invasion assay.Specific inhibitor NSC23766 added into GSCs; measured activation Western blotting expressions human orthology...