A5100374191- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Peptidase Inhibition and Analysis
- Sulfur Compounds in Biology
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Congenital heart defects research
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- Carcinogens and Genotoxicity Assessment
- Signaling Pathways in Disease
- Bioinformatics and Genomic Networks
University of Chinese Academy of Sciences
2025
Chinese Academy of Sciences
2016-2025
BGI Group (China)
2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
China Medical University
2023
First Hospital of Jilin University
2023
Jilin University
2023
Qilu Hospital of Shandong University
2023
Chengdu University of Traditional Chinese Medicine
2022
Abstract Glioblastomas (GBMs) are the most prevalent and devastating primary intracranial malignancies have extensive heterogeneity. Notch1 signaling is a more complex process in development of numerous cell tissue types, including gliomagenesis progression, upregulated glioma-initiating cells. However, contradictory expression among lower grade gliomas GBMs confounds our understanding GBM biology has made identifying effective therapies difficult. In this study, we validated that NF-κB(p65)...
// Ming-Ming Wei 1, * , Yong-Chun Zhou 2, Zhe-Sheng Wen 3, Bo Yun-Chao Huang 2 Gui-Zhen Wang 1 Xin-Chun Zhao Hong-Li Pan Li-Wei Qu Jian Zhang Chen Xin Cheng Guang-Biao State Key Laboratory of Membrane Biology, Institute Zoology, Chinese Academy Sciences, Beijing 100101, China Department Thoracic Surgery, The Third Affiliated Hospital Kunming Medical University (Yunnan Tumor Hospital), 650106, 3 Cancer Hospital, Sun Yat-Sen University, Guangzhou 510060, These authors have contributed equally...
The repressor element 1 silencing transcription factor (REST) has been proposed to function as a silence gene by binding (RE1), highly conserved DNA motif. functions of REST in various tumors have studied, but its role and correlation with immune cell infiltration remains uncertain gliomas. expression was analyzed datasets Cancer Genome Atlas (TCGA) the Genotype-Tissue Expression (GTEx) validated Gene Omnibus Human Protein databases. clinical prognosis evaluated survival data TCGA cohort...
Due to increased glycolysis and poor local perfusion, solid tumors are usually immersed in an acidic microenvironment. While extracellular acidosis is cytotoxic, cancer cells eventually become acclimated it. previous studies have addressed the acute effect of on cells, little known about how survive chronic acidosis. In this study we exposed colorectal (CRC) (HCT15, HCT116 LoVo) pH (pH 6.5) continuously for over three months obtained CRC that pH, designated as CRC-acidosis-acclimated or...
Accumulating evidence suggested that lncRNA MALAT1 plays critical roles in the commencement and progression of malignant cancers. Nevertheless, function colorectal cancer (CRC) remains largely unknown. In present study, we reported expression is significantly upregulated CRC correlated with advanced TNM stage, lymph node metastasis, worse prognosis patients. Functional assays revealed knockdown reduced cell growth invasion abilities vitro. Mechanistically, discovered may serve as a competing...
Pulmonary arterial hypertension (PAH) is a progressive syndrome. When PAH occurs, the circulatory resistance of pulmonary vasculature will gradually increase, which may lead to right heart failure and death. Pathological features include abnormal proliferation vascular smooth muscle cells remodeling. Hypoxia main cause PAH, directly induces contraction artery (PASMCs), eventually leads Recent studies have shown that long non‑coding RNAs (lncRNAs) play key roles in numerous biological...
Uterine corpus endometrial carcinoma (UCEC) is a common gynecological malignancy with high rates of mortality and morbidity. The expression long non‑coding RNA bladder cancer‑associated transcript 2 (BLACAT2) has been previously found to be aberrantly upregulated in UCEC. However, the regulatory consequences this UCEC progression remain poorly understood. In present study, human cell lines AN3CA HEC‑1‑A were infected lentiviruses overexpress BLACAT2 (Lv‑BLACAT2) or knock down using short...
To investigate the expression characteristics of long non-coding RNA SNHG14 in nasopharyngeal carcinoma (NPC) and its effects on epithelial-mesenchymal transition development nano-coated si-SNHG14 as an anti-tumor agent. The cancerous adjacent non-cancerous tissues was monitored using reverse transcriptionpolymerase chain reaction (RT-PCR). Gain- loss-of-function experiments tested regulation SNHG14, miR- 5590-3p, ZEB1 PD-L1. binding association between above three factors verified...
Papillary thyroid carcinoma (PTC) is the most common malignancy. Long non coding RNAs (lncRNAs) have been involved in regulating tumor progression including PTC. In present study, we demonstrated that long RNA LINC01186 was significantly downregulated PTC tissue samples compared with adjacent normal patients. expression also found to be higher cells. Lower associated lymph node metastasis of Functionally, overexpression suppressed cell proliferation, colony formation and invasion ability...
The tumor microenvironment is critical for growth and metastasis, but the underlying molecular mechanisms are poorly understood. Recent studies have shown that IκB-kinase-ε (IKKε) involved in proliferation migration of certain cancers. However, functional role IKKε progression gastric cancer (GC) remains unknown. In this study, we found high levels expression GC tumors were correlated with more advanced disease poor overall survival patients. Silencing effectively suppressed migratory...
Background: Angiogenesis is one of the most prominent markers cancer progression and contributes to tumor metastasis prognosis. Anti-angiogenic drugs have proven effective in treating metastatic colorectal cancer. However, there some uncertainty regarding potential role angiogenesis-related genes microenvironment. Methods: We analyzed 1,214 samples identify alterations (ARGs), then correlated angiogenesis with clinical features, prognosis, TME. The ARGs expression profiles were using three...
e23000 Background: Altered cellular metabolism is now generally acknowledged as a hallmark of cancer cells, the resultant abnormal oncometabolites cause both metabolic and nonmetabolic dysregulation potential transformation to malignancy. A subset cancers has been found be associated with mutations in succinate dehydrogenase genes which result accumulation succinate. However, function tumorigenesis remains unclear. In present study, we aim investigate role oncometabolite tumor angiogenesis....
Abstract Clinical symptoms of coronavirus disease 2019 (COVID-19) range from asymptomatic to severe pneumonia and death. Detection individuals at high risk for critical condition is crucial control the disease. Herein, first time, we profiled analyzed plasma cell-free DNA (cfDNA) mild COVID-19 patients. We found that in comparison between patients, Interleukin-37 signaling was one most relevant pathways; top significantly altered genes included POTEH, FAM27C, SPATA48, which were mostly...
Figure S5. Knockdown of STL inhibited the adipogenic differentiation DPSCs in vitro. (a, b) Oil red staining (a) and a quantitation analysis (b) revealed significant decrease lipid deposits STL-depleted compared to control groups 3 weeks after induction. One-way ANOVA was performed determine statistical significance. All error bars represent SD (n = 3). NS; no difference, **p