A5002005109- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Air Quality and Health Impacts
- Neurosurgical Procedures and Complications
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Climate Change and Health Impacts
- Cancer-related gene regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Noise Effects and Management
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Pain Management
- Parkinson's Disease Mechanisms and Treatments
- Polyomavirus and related diseases
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Atrial Fibrillation Management and Outcomes
- Alcohol Consumption and Health Effects
- Air Quality Monitoring and Forecasting
Hospital Del Mar
2016-2024
Hospital de Sant Joan Despí Moisès Broggi
2022-2024
Institut d'Investigació Biomédica de Bellvitge
2023
Hospital Universitari de Vic
2023
Universitat de Barcelona
2023
Universitat Autònoma de Barcelona
2019-2022
Municipal Institute for Medical Research
2017-2022
Universitat Pompeu Fabra
2019-2021
Hospital del Mar Research Institute
2019-2021
Parc de Salut
2017
<h3>Importance</h3> It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days. An incomplete microcirculatory might contribute to these suboptimal clinical benefits. <h3>Objective</h3> To investigate whether treatment adjunct intra-arterial alteplase improves outcomes following reperfusion. <h3>Design, Setting, Participants</h3> Phase 2b randomized,...
Evidence for the association between environmental exposures and ischemic stroke (IS) is limited inconsistent. We aimed to assess relationship exposure air pollutants, residential surrounding greenness, incident IS, identify population subgroups particularly sensitive these exposures. used data from administrative health registries of public healthcare system in Catalonia, Spain construct a cohort individuals aged 18 years older without previous diagnosis at 1st January 2016 (n = 3 521 274)....
The association between long-term exposure to ambient air pollutants and severe COVID-19 is uncertain. We followed 4,660,502 adults from the general population in 2020 Catalonia, Spain. Cox proportional models were fit evaluate annual averages of PM2.5, NO2, BC, O3 at each participant's residential address COVID-19. Higher BC was associated with an increased risk hospitalization, ICU admission, death, hospital length stay. An increase 3.2 µg/m3 PM2.5 a 19% (95% CI, 16-21) hospitalizations....
To describe short-term and 5-year rates of mortality poor outcome in patients with spontaneous aneurysmal subarachnoid hemorrhage (aSAH) who received repair treatment.
Background and Purpose- Our aim was to describe variables associated with initial misdiagnosis of subarachnoid hemorrhage (SAH). We also analyzed the relationship poor outcome complications in good Hunt Hess (HH) cases. Methods- In a prospective cohort 401 patients SAH, defined as failure correctly identify, at first physician contact, subsequently documented SAH; this meant no urgent radiological study lumbar puncture performed. Poor modified Rankin Scale score 3 6 3-month follow-up....
DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle environmental factors, as well genetic variation. The leading variants at stroke risk loci identified to date explain roughly 1–2% of heritability. Most these single nucleotide polymorphisms situated within a regulatory sequence marked DNase I hypersensitivity sites, which would indicate involvement an epigenetic mechanism. To detect associated with occurrence subtypes.A two-stage...
Although nonopiate analgesics may be particularly useful in the immediate postoperative period after major surgery, their use has been associated with haemodynamic adverse effects during pain treatment and critically ill patients intensive care. The effect of a single intravenous dose metamizol (dipyrone) 2g, ketorolac 30mg propacetamol 1g on variables control heart surgery is compared. Seventy-two undergoing elective coronary and/or valve were included cohort study 1-years duration (1998)....
Un porcentaje de casos diagnosticados inicialmente como infartos isquémicos son causa no cerebrovascular o stroke mimics (SM). Los datos publicados al respecto heterogéneos y, generalmente, con cohortes pequeñas. Nuestro objetivo es establecer qué enfermedades cursan SM, definir sus características epidemiológicas y clínicas e identificar el tratados fibrinólisis. Registro prospectivo los eventos considerados cerebrovasculares desde junio del 2005 a abril 2015, analizando demográficos,...
Background and purpose Patients with acute intracerebral hemorrhage ( ICH ) pretreated antithrombotic drugs may have increased early hematoma growth, which would increase mortality risk. The effect of antiplatelet AP vitamin K antagonist VKA pretreatment on ultra‐early growth uHG its relationship in patients supratentorial was analyzed. Methods This is an observational retrospective study a prospective register 197 first computed tomography CT scan taken <6 h from symptom onset. volume...
A considerable percentage of events initially diagnosed as ischaemic stroke have non-cerebrovascular causes; these are called mimics (SM). Currently available evidence about is heterogeneous and comes from studies with small samples. The purpose our study to identify conditions that may present SM, define their epidemiological clinical characteristics, determine the cases SM treated intravenous fibrinolysis. Prospective including all patients admitted a tertiary university hospital between...
To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification.A prospective cohort of 706 TIA patients was followed up in a single tertiary center. Endpoint SR. Etiologic subgroup determined the evidence-based causative classification system. Location and SR recorded as right, left, or posterior territory. Disability (DSR) defined modified Rankin Scale (mRS) score >1 onepoint increase those with previous mRS...
Alcohol overuse (AOu) is considered an important risk factor for spontaneous intracerebral hemorrhage (ICH). The clinical and outcome characteristics of these patients (AOu-ICH) are not well known.All with ICH admitted to a single university tertiary stroke center were prospectively studied from May 2005 2015. Demographic profiles, radiologic outcomes acute previous AOu (>40 g/day or >300 g/week) analyzed.During the study period, 555 primary met inclusion criteria. A total 81 (14.6%)...
Although nonopiate analgesics may be particularly useful in the immediate postoperative period after major surgery, their use has been associated with haemodynamic adverse effects during pain treatment and critically ill patients intensive care. The effect of a single intravenous dose metamizol (dipyrone) 2 g, ketorolac 30 mg propacetamol 1 g on variables control heart surgery is compared. Seventy-two undergoing elective coronary and/or valve were included cohort study 1-years duration...
Pyramidal signs (hyperreflexia, spasticity, Babinski sign) are essential for the diagnosis of amyotrophic lateral sclerosis (ALS). However, these not always present at onset and may vary over time, besides which their role in disease evolution is controversial. Our goal was to describe pyramidal were how they evolved a cohort patients with ALS, as well prognosis. Retrospective analysis prospectively collected diagnosed ALS our centre from 1990 2015. Of total 130 34 (26.1%) showed no first...
Los signos piramidales (hiperreflexia, espasticidad, signo de Babinski) son fundamentales para el diagnóstico esclerosis lateral amiotrófica (ELA). Sin embargo, no siempre están presentes al comienzo, pueden variar con tiempo y es controvertido su papel en la evolución. El objetivo del estudio describir qué inicialmente cómo evolucionan una cohorte pacientes ELA, así como pronóstico. Análisis retrospectivo recogidos manera prospectiva, diagnosticados ELA nuestro centro, desde 1990 hasta...
Introduction: Arterial stiffness may have a significant impact on the development of cerebral small vessel disease (cSVD). Patients and methods: We obtained pulse wave velocity (24-h PWV) by means ambulatory blood pressure monitoring (ABPM) in patients with recent subcortical infarct (RSSI). known cardiac or arterial embolic sources were excluded. Lacunes, microbleeds, white matter hyperintensities enlarged perivascular spaces at baseline assessed brain MRI included cSVD score. A follow-up...
We analyzed the main factors associated with intravenous thrombolysis (IVT) in patients minor ischemic stroke.Data were obtained from a prospective, government-mandated, population-based registry of stroke code Catalonia (6 Comprehensive Stroke Centers, 8 Primary and 14 TeleStroke Centers). selected diagnosed National Institutes Health Scale (NIHSS) ≤5 at hospital admission January 2016 to December 2020. excluded baseline modified Rankin score ≥3, absolute contraindication for IVT, unknown...
Objective The modified Centers for Disease Control and Prevention (mCDC) criteria have been proposed diagnosing managing stroke-associated pneumonia (SAP). objective was to investigate the impact of SAP on stroke outcome depending whether or not it conforms mCDC criteria. Our secondary identify responsible factors antibiotic initiation in patients. Methods We conducted a prospective, multicenter, observational study ischemic patients with moderate severe (NIHSS≥4) admitted within 24 h. For 7...
Background Cerebral edema (CED) is associated with poorer outcome in patients acute ischemic stroke (AIS). The aim of the study was to investigate factors contributing greater early CED formation AIS who underwent endovascular therapy (EVT) and its association functional outcome. Methods We conducted a multicenter cohort an anterior circulation undergoing EVT. volume cerebrospinal fluid (CSF) extracted from baseline 24-hour follow-up CT using automated algorithm. severity quantified by...