Yuying Zhao

ORCID: 0000-0003-4859-834X
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About
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Research Areas
  • Genetic and Kidney Cyst Diseases
  • Genetic Syndromes and Imprinting
  • Pancreatic function and diabetes
  • Metabolism and Genetic Disorders
  • Kruppel-like factors research
  • Folate and B Vitamins Research
  • Air Quality and Health Impacts
  • Coronary Interventions and Diagnostics
  • Cellular Mechanics and Interactions
  • Adipose Tissue and Metabolism
  • Sulfur Compounds in Biology
  • Diet and metabolism studies
  • Mitochondrial Function and Pathology
  • Ion channel regulation and function
  • Muscle and Compartmental Disorders
  • Phytochemical Studies and Bioactivities
  • Skin Protection and Aging
  • Infant Health and Development
  • Fungal Biology and Applications
  • Cholinesterase and Neurodegenerative Diseases
  • Extracellular vesicles in disease
  • Natural product bioactivities and synthesis
  • Acupuncture Treatment Research Studies
  • Pain Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research

Shenzhen University
2024

Shanghai East Hospital
2024

Qilu Hospital of Shandong University
2017-2024

University of Iowa
2000-2024

Qufu Normal University
2024

Shandong Normal University
2022-2023

Shanghai Children's Medical Center
2023

People's Liberation Army 401 Hospital
2023

Mayo Clinic in Florida
2020

Bethune International Peace Hospital
2014

Ferroptosis, a new regulatory cell death modality, underlies the pathogenesis of broad range disorders. Although much efforts have been made to uncover molecular mechanisms, some mechanistic details ferroptosis still remain poorly understood. Particularly, functional relevance mitochondrial reactive oxygen species (ROS) in is highly controversial, which partially due fact that it remains puzzled how ROS level varies during ferroptosis. The conventional mitochondria-targeted probes may react...

10.1021/acs.analchem.2c01758 article EN Analytical Chemistry 2022-07-06

We designed and synthesized an oxindole-functionalized two-photon fluorescent probe based on a naphthalimide fluorophore, which enabled in situ visualization of the overwhelming peroxynitrite flux during amyloid-β-induced neuronal ferroptosis cerebral stress live mice with Alzheimer's disease.

10.1039/d2cc01744j article EN Chemical Communications 2022-01-01

Abstract Skin aging is characterized by the disruption of skin homeostasis and impaired injury repair. Treatment has long been limited unclear intervention targets delivery techniques. Engineering extracellular vesicles (EVs) as an upgraded version natural EVs holds great potential in regenerative medicine. In this study, we found that expression critical antioxidant detoxification gene Gstm2 was significantly reduced skin. Thus, constructed primary fibroblasts-derived encapsulating mRNA...

10.1186/s12951-024-02541-1 article EN cc-by Journal of Nanobiotechnology 2024-06-02

MicroRNA (miRNA) plays a critical function in the progression of acute coronary syndrome (ACS) and is associated with major adverse cardiovascular events (MACEs) after undergoing percutaneous intervention (PCI). This research was designed to probe diagnostic accuracy miR-483-5p patients ACS its predictive value MACEs.118 (40 unstable angina pectoris [UAP] 78 myocardial infarction [AMI]) 75 healthy controls were enrolled. Serum detected subjects by reverse transcription-quantitative real-time...

10.1186/s12872-023-03387-5 article EN cc-by BMC Cardiovascular Disorders 2023-07-18

To determine the ability of radiation to modulate kidney tubule epithelial cell expression various molecules involved in regulating extracellular matrix accumulation (collagen types I and III, fibronectin, plasminogen activator-inhibitor 1 (PAI-1), TGF-beta tissue inhibitor metalloproteinases-2 (TIMP-2)) degradation (plasminogen activators u-PA or t-PA, MMP-2 MMP-9).NRK52E rat cells were placed serum-free medium 24 h prior irradiation with single doses 1.0-10.0 Gy 137Cs gamma-rays. After...

10.1080/095530000138736 article EN International Journal of Radiation Biology 2000-01-01

Abstract Objective To investigate the clinical features of Han Chinese patients with anti‐neurofascin‐155 (NF155) antibody‐positive neuropathy. Methods We screened 194 peripheral neuropathy for NF155 antibodies using a cell‐based assay (CBA) and teased‐fiber immunofluorescence assay. summarized findings seropositive patients. Results The sera from 17 reacted to human embryonic kidney 293 cells transfected NF155. Eleven these had immunoglobulin G (IgG) 4 isotype, younger onset age, tremor,...

10.1002/acn3.51550 article EN Annals of Clinical and Translational Neurology 2022-03-21

Elevated plasma level of homocysteine, also termed as hyperhomocysteinemia, is acknowledged a significant and independent risk factor Alzheimer's disease. However, the mechanistic insight has not been thoroughly elucidated yet. In this work, 3,5-dihydroxybenzyloxy was explored unique reaction trigger integrated into naphthalimide fluorophore via carbamate linker to afford new probe for •OH imaging. treatment induced aromatic hydroxylation subsequent elimination release caged fluorophore,...

10.1021/acs.analchem.3c00822 article EN Analytical Chemistry 2023-06-22

Abstract Background Combined methylmalonic acidemia (MMA) and hyperhomocysteinemia, cobalamin C (cblC) type, also named cblC deficiency is a rare autosomal recessive genetic metabolic disease. It progressively causes neurological, hematologic, renal other system dysfunction. The clinical manifestations are relatively different due to the onset time of Case presentation This report describes case 26 year old man with who developed life-threatening aortic dissection acute kidney injury (AKI)...

10.1186/s12882-023-03414-9 article EN cc-by BMC Nephrology 2024-01-04

Objective The aim of this study was to examine the role intracoronary anisodamine and diltiazem administration performed before stenting on immediate angiographic clinical outcome in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods STEMI during PCI were randomized two bolus injections (1 mg/5 ml) (2 (COM group, n=54) or saline (5 (diltiazem stenting. endpoint incidence no/slow reflow [thrombolysis (TIMI) flow...

10.1097/mca.0000000000000167 article EN Coronary Artery Disease 2014-09-17

The ongoing epidemic of obesity and associated illnesses highlights the need to understand biological processes that regulate energy balance. Here, we identified an important role for a protein complex called BBSome in control hepatic function. We show liver is necessary maintain body weight blood glucose levels due its requirements generate detect insulin, hormone essential metabolic regulation.

10.1152/ajpendo.00174.2023 article EN AJP Endocrinology and Metabolism 2023-11-01

The cssR gene (ncgl1578) of Corynebacterium glutamicum encodes a repressor the TetR (tetracycline regulator) family. Its role in stress response to antibiotics/heavy metals has been investigated, but how CssR functions phenolic compounds C. rarely studied. In this study, we applied transcriptomic analysis, β-galactosidase qRT-PCR, and EMSAs analyze target genes compounds. Consistent with upregulation involved degradation compounds, ΔcssR mutant was more resistant various than wild-type...

10.1016/j.heliyon.2024.e27929 article EN cc-by-nc Heliyon 2024-03-01

The current study show how genetic manipulation of fat cells impacts various functions the body including sensitivity to hormone insulin.

10.1152/ajpregu.00039.2024 article EN AJP Regulatory Integrative and Comparative Physiology 2024-05-13

Extracellular vesicles (EVs) are lipid-bilayer membrane-enclosed well known to mediate cell-cell communication maintain normal physiological functions. The diverse cargo of EVs encompassing proteins, lipids and miRNAs represent potential biomarkers therapeutic targets. However, the role adipocyte-derived (AdEVs) in obesity is still unknown. To address this, we performed proteomic profiling AdEVs isolated from C57BL/6 male mice that were fed either a chow diet (NCD) or high-fat high-sucrose...

10.1152/physiol.2024.39.s1.881 article EN Physiology 2024-05-01

Hibifolin, the highest-content bioactive flavonoid of flowers Abelmoschus manihot, was incubated with human intestinal bacteria, and four metabolites (1–4) were obtained from solution by chromatographic methods. The structures elucidated as gossypetin 8-O-β-D-4′′-deoxy-Δ 4′′-glucuropyranoside (1), (2), quercetin (3), 8-methoxy-quercetin (4), respectively, on basis UV, NMR, MS data. Metabolite 1 a new compound specific β-D-4′′-deoxy-Δ 4′′-glucuropyranosyl moiety, which formed through unique...

10.1055/s-0029-1185317 article EN Planta Medica 2009-02-20

The interplay of the enteric nervous system (ENS) and SIP syncytium (smooth muscle cells–interstitial cells Cajal–PDGFRα+ cells) plays an important role in regulation gastrointestinal (GI) motility. This study aimed to investigate dynamic regulatory mechanisms ENS-SIP on colon motility during postnatal development. Colonic samples 1-week-old (PW1), 3-week-old (PW3), 5-week-old (PW5) mice were characterized by RNA sequencing, qPCR, Western blotting, isometric force recordings (IFR), colonic...

10.3390/biom13121688 article EN cc-by Biomolecules 2023-11-23

The BBSome, a protein complex of 8 Bardet-Biedl syndrome (BBS) proteins including BBS1, has emerged as an important regulator metabolic function. BBSome deficient human and mice display several features obesity type 2 diabetes. Here, we show that lacking the specifically in liver which were generated by crossing Bbs1 fl/fl with liver-specific (albumin) Alb Cre exhibit significantly higher lipid droplets liver, Oil Red-O staining, primary cultured hepatocytes (5.7%±0.4% vs 2.4%±0.6%,...

10.1152/physiol.2024.39.s1.281 article EN Physiology 2024-05-01

Best known as the powerhouse of cell, mitochondria play a crucial role in obesity and associated cardiovascular diseases. A-kinase anchoring protein 1 (AKAP1) is mitochondrial scaffold that regulates function by promoting kinase A (PKA)-mediated phosphorylation Dynamin-related at Ser637 through recruitment PKA to outer membrane. However, AKAP1 regulation blood pressure development hypertension not known. Here, we used mice harboring Akap1 gene deletion investigate importance obesity-...

10.1152/physiol.2024.39.s1.459 article EN Physiology 2024-05-01

Increasing evidence suggests that tumor cells exhibit extreme plasticity in migration modes order to adapt microenvironments. However, the underlying mechanism for governing mode switching is still unclear. Here, we revealed epithelial could develop a stable directional driven by hyperactivated ERK activity. This highly activated and dynamically changing activity, called pERK transition, crucial inducing switch from pauses state movement also necessary maintaining mode. PERK transition...

10.1073/pnas.2318871121 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2024-12-13

Primary cilia possess an array of receptors and signaling from this organelle is critical for neuronal function. BBS1 important component a receptor trafficking complex (BBSome) that facilitates in both primary plasma membrane. Humans harboring mutations develop obesity type 2 diabetes. Recent studies our lab others have shown deletion hypothalamic neurons lead to glucose dysregulation. However, the role hindbrain metabolic control unknown. We hypothesized brainstem regulates metabolism...

10.1152/physiol.2023.38.s1.5731595 article EN Physiology 2023-05-01
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