Two hundred and three patients, 148 males 55 females, who during the last month before admission had experienced at least one reversible cerebral ischemic attack of less than 72 hours duration, were randomly assigned to treatment with either acetylsalicylic acid (ASA) 1000 mg daily (101 patients) or placebo (102 patients). The average follow-up period was 25 months. two groups comparable respect age, sex, associated diseases, risk factors, number duration attacks. No statistically...

Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether dementia among people with comorbid DM is higher than sum of each exposure individually.To examine all-cause persons depression, DM, or both compared neither exposure.We performed a national population-based cohort study 454 532 adults, including 477 133 (19.4%) 223 174 (9.1%) 95 691 (3.9%) both. We included all living Danish citizens 50 years older who...

Two for the price of one: A Pd/dppf-based catalyst provides access to title compounds from 1,2-dihalogenated aromatic and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity iodide ensure formation indole regioisomer, which can be functionalized situ by N-arylation (see scheme). dba=dibenzylideneacetone, dppf=1,1′-bis(diphenylphospanyl)ferrocene. Supporting information this article is available on WWW under...

Parental death from suicide is associated with increased risk of in the bereaved child, but little known about long-term risks after parental other causes. A better understanding this association may improve prevention efforts.To examine and how trajectories differed by cause while accounting for major potential confounding variables.A population-based matched cohort study was performed using information nationwide registers (data 1968 to 2008) 3 Scandinavian countries (for a total 7,302,033...

A general scheme is described for the in vitro evolution of protein catalysts a biologically amplifiable system. Substrate covalently and site specifically attached by flexible tether to pIII coat filamentous phage that also displays catalyst. Intramolecular conversion substrate product provides basis selecting active from library mutants, either release or attachment solid support. This methodology has been developed with enzyme staphylococcal nuclease as model. An analysis factors...

1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine (Lu AA21004) is a novel antidepressant that currently in late-stage clinical development for major depressive disorder. In the present study, metabolism of Lu AA21004 was investigated using human liver microsomes (HLM), S9 fraction, and recombinant enzymes. found vitro to be oxidized 4-hydroxy-phenyl metabolite, sulfoxide, an N-hydroxylated piperazine, benzylic alcohol, which further corresponding benzoic acid...

Binding and signaling kinetics have previously proven important in validation of biased agonism at GPCRs. Here we provide a comprehensive kinetic pharmacological comparison clinically relevant μ-opioid receptor agonists, including the novel agonist oliceridine (TRV130) which is clinical trial for pain management. We demonstrate that bias profile observed selected agonists not time-dependent with dramatic differences their binding properties can display same degree bias. analyses...

Summary Objective We studied the potential impact of antiepileptic drugs ( AED s) on fetal growth and gestational age at birth. Methods In Danish Medical Birth Registry, we identified all pregnancies with birth outcomes from 1997 to 2008 linked data National Prescription Register. used binomial regression study preterm (<37 weeks), low weight (<2,500 g), small for SGA ), adjusted confounding factors including maternal age, smoking, substance abuse, cohabitation, income, education,...

The development of a novel traceless linking strategy for the solid-phase synthesis small non-peptide compounds by use resin-bound selenium is described. Compounds were attached direct loading without requirement an auxiliary spacer. We demonstrate [2 × 3]-sized library single alkyl aryl ethers with two points diversity Mitsunobu reaction. selenium−alkyl bond that attaches to resin was smoothly cleaved under radical conditions homolysis tributylstannane and catalytic amount AIBN generate...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBioisosteres of Arecoline: 1,2,3,6-Tetrahydro-5-pyridyl-Substituted and 3-Piperidyl-Substituted Derivatives Tetrazoles 1,2,3-Triazoles. Synthesis Muscarinic ActivityEjner K. Moltzen, Henrik Pedersen, Klaus P. Boegesoe, Eddi Meier, Kristen Frederiksen, Connie Sanchez, Hanne Loeve LemboelCite this: J. Med. Chem. 1994, 37, 24, 4085–4099Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November...

Multimorbidity (MM) is more prevalent among people of lower socioeconomic status (SES), and both MM SES are associated with higher mortality rates. However, little known about the relationship between SES, MM, mortality. This study investigates association educational level mortality, to what extent modifies this association.We followed 239,547 individuals invited participate in Danish National Health Survey 2010 (mean follow-up time: 3.8 years). was assessed by using information on drug...

Hospitalizations for ambulatory care-sensitive conditions (ACSCs) and early rehospitalizations increase health care costs.To determine if individuals with serious mental illnesses (SMIs) (eg, schizophrenia or bipolar disorder) are at increased risk hospitalizations ACSCs, rehospitalization the same another ACSC, within 30 days.Population-based cohort study.A total of 5.9 million Danish persons aged 18 years older between January 1, 1999 December 31, 2013.The Psychiatric Central Register...

We propose a novel ethylenediamine plasma-polymerized film matrix that is deposited on gold surfaces for use in surface plasmon resonance immunosensing. The films formed the are extremely thin (∼100 nm), homogeneous, demonstrate good adhesion, have flat profile, and incorporate amino groups to introduce chemical functionality. A sensor chip made with has many advantages when compared conventionally used designs such as carboxylated dextran hydrogels. For example, shows better response than...

Covalent binding of proteinases by human alpha 2-macroglobulin (alpha 2M) results primarily from the formation stable epsilon-Lys-gamma-Glu isopeptide bonds. Cross-linking engages 12, 13, and 10 14, 11 Lys residues in chymotrypsin, trypsin, subtilisin, respectively, reaction with alpha-amino group C-chain chymotrypsin B-chain beta-trypsin is also seen. In contrast, cross-linking only 6 thermolysin. each these proteinases, a few react to greatest extent: Lys36, Lys79, Lys87, Lys93...

Abstract Integral to the development of embryonic stem cell therapeutic strategies for hepatic disorders is identification and establishment a controllable differentiation strategy. In order address this issue we have established an alginate microencapsulation approach which provides means modulate process through changes in key encapsulation parameters. We report that wide array hepatocyte specific markers expressed by cells differentiated during 23‐day period within bead microenvironment....

Abstract Addition of an ethylene precursor, ethephon, was studied in plant‐cell‐suspension cultures Coffea arabica and Thalictrum rugosum as enhancer secondary metabolite production. In both cases the compound able to stimulate alkaloid production, even though biochemical pathways are widely different. This suggests that or more directly ethylene, may be valuable increasing levels a variety cell‐suspension culture systems.

Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and vivo for depletion of circulating blood. Sustained reduction was achieved less than 30 minutes. A 50 percent decrease obtained a 2-hour application maintained more 2 days. Similar have therapeutic potential temporary management phenylketonuric patients when their becomes exceedingly high because infection, fever, or pregnancy.

Hospitalisations for ambulatory care-sensitive conditions (ACSCs), a group of chronic and acute illnesses considered not to require inpatient treatment if timely appropriate care is received, early rehospitalisations are common costly. We sought determine whether individuals with depression at increased risk hospitalisations ACSCs, rehospitalisation the same or another ACSC, within 30 days.National, population-based cohort study.Denmark.5,049,353 ≥ 18 years age between 1 January 2005 31...

Objectives Severe psychological stress is generally associated with an increased risk of acute cardiovascular diseases, such as myocardial infarction, but it remains unknown whether also applies to atrial fibrillation. We conducted a population-based case–control study using nationwide Danish health registers examine the fibrillation after death partner. Methods From 1995 through 2014, we identified 88 612 cases hospital diagnosis and 886 120 age-matched sex-matched controls based on...