A5101468487- Fish Ecology and Management Studies
- Fish Biology and Ecology Studies
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Gas Sensing Nanomaterials and Sensors
- Cancer Immunotherapy and Biomarkers
- Analytical Chemistry and Sensors
- Trace Elements in Health
- Bioactive natural compounds
- Cancer Mechanisms and Therapy
- Advanced Chemical Sensor Technologies
- Metalloenzymes and iron-sulfur proteins
- Reproductive biology and impacts on aquatic species
- Adipokines, Inflammation, and Metabolic Diseases
- Receptor Mechanisms and Signaling
- Histone Deacetylase Inhibitors Research
- Nonlocal and gradient elasticity in micro/nano structures
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Nuclear Receptors and Signaling
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
Northeast Agricultural University
2024
Harbin Medical University
2024
Guangzhou University of Chinese Medicine
2024
Shandong University of Traditional Chinese Medicine
2021-2023
Nantong University
2023
Harbin University of Science and Technology
2023
Nanjing University of Chinese Medicine
2021
Hainan Medical University
2021
University of South Florida
2021
Qiqihar Medical University
2020
In vertebrate retina, melatonin regulates various physiological functions. this work we investigated the mechanisms underlying melatonin-induced potentiation of glycine currents in rat retinal ganglion cells (RGCs). Immunofluorescence double labelling showed that RGCs were solely immunoreactive to MT(2) receptors. Melatonin potentiated RGCs, which was reversed by receptor antagonist 4-P-PDOT. The effect blocked intracellular dialysis GDP-beta-S. Either preincubation with pertussis toxin or...
Abstract Background The mechanism by which circRERE (hsa_circ_0006837) modulates the malignant progression of gastric cancer was investigated to identify a novel biomarker and therapeutic target for this disease. Methods Hsa_circ_0006837 expression in GC tissues cells detected RT-qPCR. Several data analysis methods were used evaluate significance dysregulated hsa_circ_0006837 GC. patients followed up five years, survival conducted using Kaplan-Meier curves. Cox regression subsequently...
Abstract Metabolic stress-induced low-grade chronic inflammation plays an important role in the development of insulin-resistance and type 2 diabetes (T2D). Emerging evidence highlights importance directly elucidating T-cell activation under obesity-induced metabolic stress condition, as T cells primed such conditions were found to acquire a unique phenotype function. Herein, we significant upregulation signaling lymphocytic molecule family member 3 (SLAMF3) expression on from T2D patients...
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Atrazine is widely used in agriculture and a known endocrine disrupting chemical. can seep into the water body through surface, posing potential threat to aquatic ecological environment human drinking source. In vertebrate, studies have shown that it affect reproduction development seriously, but its molecular mechanism for animals unknown. Aquaculture very common China, especially carp, whose females grow faster than males. However, effects of atrazine on miRNA, not been investigated.In...
Objective: To clarify the role of LINC00665 in ovarian cancer (OC) progression and possible mechanism.Methods: levels OC tissues cell lines were detected by qRT-PCR.The correlation between clinicopathologic characteristics patients was assessed.Biological functions phenotypes influenced examined CCK-8, colony formation Transwell assay.Dual-luciferase reporter assay RIP conducted to verify interaction its downstream target.Results: upregulated linked poor prognosis.Knockdown blocked malignant...
The present study aimed to explore the expression of microribonucleic acid (microRNA) (miR)-205 in bone tissues and serum elderly female patients with type 2 diabetes mellitus (T2DM) complicated osteoporosis (OP), investigate effect miR-205 on osteogenesis/adipogenesis marrow mesenchymal stem cells (BMSCs) its mechanism mice T2DM + OP. 24 OP at Third Affiliated Hospital Qiqihar Medical University were collected as research group, while those healthy people control group. level was detected...
Telomerase and micro-RNAs (miRNAs) are simultaneously upregulated in a variety of tumor cells have emerged as promising markers. However, sensitive detection telomerase miRNAs situ remains great challenge due to their low expression levels. Here, we designed Boolean logic "AND" signal amplification strategy based on functionalized ordered mesoporous nanoparticles (FOMNs) achieve ultrasensitive miR-21 living cells. Briefly, the uses an input enable release DNA3-ROX-BHQ hairpins by making...
Ischemic stroke caused by atherosclerosis (AS) poses a serious threat to human life expectancy and quality. With the development of genome-wide association studies, histone deacetylase 9 (HDAC9) expression atheromatous plaques with ischemic in large arteries has been revealed, but molecular mechanisms behind this phenomenon have not elucidated. In study, we explored effect HDAC9 on P38 mitogen activated protein kinase (P38 MAPK), classic cellular inflammation-related pathway, knocking down...
Abstract Cadmium is considered one of the most harmful carcinogenic heavy metals in human body. Although many scientists have performed research on cadmium toxicity mechanism, toxicokinetic process remains unclear. In present study, kinetic response proteome in/and A549 cells to exposure exogenous was profiled. were treated with sulfate (CdSO 4 ) for different periods and expressions proteins detected by two‐dimensional gel electrophoresis. The related further investigated reverse...
Purpose: The rapidly rising incidence of esophageal adenocarcinoma (EAC), which is usually diagnosed late with a poor prognosis, has become growing problem. This study investigated the potential transcription factor (TF)-related molecular mechanisms EAC by using bioinformatics analysis and qRT-PCR validation. Methods: Expression profile datasets for mRNAs (GSE92396, GSE13898, GSE26886 GSE1420) miRNAs (GSE16456) were downloaded from GEO database. Overlapping differentially expressed genes...
In the last several years, as evidence of a surged number GPCR-G complex structures, expressions GPCRs and G proteins for structural biology have achieved tremendous successes, mostly in insect mammalian cell systems, resulting more than 370 structures over 70 been resolved. However, challenge remains, particularly conformational transition dynamics study area where much higher quantity receptors is required even comparison to X-ray cryo-EM (5 mg/ml, 3 μl/sample) when NMR spectroscopy 250 μl...
This work presents analytical solutions for thermoelastic behaviors of multilayer arches with temperature-dependent (TD) thermomechanical properties under loadings. The temperature is varied across the thickness arch. Firstly, an arched-slice model developed, which divides every layer arch into numerous hypothetical arched slices uniform properties. Based on model, nonlinear heat conduction equations are solved using iteration approach, and then obtained from two-dimensional thermoelasticity...
Background Potentilla discolor Bunge (PDB) is a plant of the Rosaceae family. A wide range pharmacological activities, such as antibacterial, hypoglycemic, and others, can be achieved through its chemical components, which include terpenes, steroids, polyphenols, flavonoids. However, effects herb on heart are unclear. Purpose To explore effect main components PDB myocardial cell membranes. Materials Methods We investigated role different concentrations in cardiomyocytes by evaluating...
Objective Pain is a prevalent discomfort symptom associated with cancer, yet the correlations and potential mechanisms between pain efficacy of cancer immunotherapy remain uncertain. Methods Non-small cell lung (NSCLC) patients who received immune checkpoint inhibitors (ICIs) in inpatient department Guangdong Provincial Hospital Chinese Medicine from January 1, 2018, to December 31, 2021, were retrospectively enrolled. Through cox regression analysis, prognostic factors independent affecting...