Federica Mainoldi
A5055544719- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Pancreatic function and diabetes
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- COVID-19 Impact on Reproduction
- IL-33, ST2, and ILC Pathways
IFOM
2013-2025
University of Milano-Bicocca
2016
Protection against deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated in germinal centers (GCs). Alteration GC developmental program is common many cell malignancies. Identification regulators response crucial to develop targeted therapies for dysfunctions, including lymphomas. The histone H3 lysine 27 methyltransferase enhancer zeste homolog 2 (EZH2) highly expressed cells and often constitutively activated GC-derived non-Hodgkin lymphomas...
Severe/critical COVID-19 is associated with immune dysregulation and plasmatic SARS-CoV-2 detection (i.e. RNAemia). We detailed the association of RNAemia responses in patients at end first week disease. enrolled hospitalized acute phase ascertained pneumonia, evaluated RNAemia, cytokines, activated/pro-cytolytic T-cells phenotypes, SARS-CoV-2-specific cytokine-producing (IL-2, IFN-γ, TNF-α, IL-4, IL-17A), simultaneous Th1-cytokines production (polyfunctionality) amount (iMFI). The humoral...
Abstract The B cell receptor (BCR) is critical for mature lymphomas, serving as a therapeutic target. We show that high-grade lymphomas with MYC and BCL2 rearrangements (HGBCL-DH-BCL2) predominantly exhibit immunoglobulin heavy (IGH) chain silencing, leading to BCR shutdown. IGH-silenced HGBCL-DH-BCL2 (IGHUND) differ from IGH+ counterparts in germinal center-zone programs, expression, immune infiltrate. While favor IGM/IG-Kappa IGHUND complete IGH isotype switching IG-Lambda rearrangements....
Abstract In vertebrates, microorganisms are recognized by pathogen recognition receptors (PRRs). Exposure of immune cells to the ligands these activates intracellular signaling cascades that rapidly induce expression a variety genes. Within genes, cytokines family plays crucial function because its role in adaptive immunity induction and tissue-specific functional regulation, such as tissue repair homeostasis during steady state conditions. myeloid compartment, dendritic (DCs) release...
Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first specific knockout (KO) mouse model of β regulatory subunit CK2. CK2β KO mice present an increase marginal zone (MZ) a reduction follicular B cells, suggesting for regulation cell receptor (BCR) NOTCH2 signaling pathways. Biochemical analyses demonstrate increased pathway animals, which sustains MZ development. Transcriptomic...
Significance Antibodies produced by B cells provide a protective barrier to our organism against the penetration and dissemination of microorganisms. Each antibody recognizes specific antigen through variable (V) region domains pairs immunoglobulin (Ig) heavy (H) light (L) chains. In mammals, VDJ recombination generates highly diversified preimmune pool V H L domains. Acquisition functional rearrangement is thought prevent further at IgH locus. Instead, mice cloned from terminally...
Abstract The B cell receptor (BCR) is essential for mature lymphomas, serving as therapeutic target. Here, we show that high-grade lymphomas with MYC and BCL2 rearrangements (HGBCL-DH- ) predominantly exhibit immunoglobulin heavy (IGH) chain silencing, leading to BCR shutdown. HGBCL-DH- undetectable IGH (IGH UND differ from IGH-expressing counterparts germinal center-zone gene programs, expression T infiltration. While + prefer IGM/IG-Kappa expression, have completed class-switching,...
B cell receptor (BCR) critically contributes to the growth of multiple types mature neoplasms, representing a preferred target therapy. In aggressive B-cell non-Hodgkin lymphomas expressing BCL2 and MYC oncoproteins, BCR status remains elusive. Immunohistochemical screening for immunoglobulin (Ig) heavy (H) chains IgM/D/G/A in 331 real-world Diffuse Large Cell Lymphomas (DLBCL) identified 65% (58/89) Double-hit (DH) Triple-hit (TH) lymphomas, carrying MYC/BCL2 (MB2) chromosomal...