A5060484371- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Lymphoma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Enhanced Recovery After Surgery
- Immune Cell Function and Interaction
- Blood groups and transfusion
- RNA modifications and cancer
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Surgical site infection prevention
- Erythrocyte Function and Pathophysiology
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Anorectal Disease Treatments and Outcomes
- Mesenchymal stem cell research
University of Electronic Science and Technology of China
2018-2025
Second Xiangya Hospital of Central South University
2022-2024
Central South University
2022-2024
Qingdao Agricultural University
2024
Southwestern University of Finance and Economics
2024
Sun Yat-sen University
2015-2023
Sun Yat-sen University Cancer Center
2015-2023
State Key Laboratory of Oncology in South China
2023
Peking University People's Hospital
2023
Peking University
2023
Abstract Our previous work identified NHA1, a testis-specific sodium–hydrogen exchanger, is specifically localized on the principal piece of mouse sperm flagellum. subsequent study suggested that number newborns and fertility rate NHA1-vaccinated female mice are significantly stepped down. In order to define physiological function NHA1 in spermatozoa, we generated Nha1 Fx/Fx , Zp3 -Cre (hereafter called cKO) found cKO males were viable subfertile with reduced motility. Notably, cyclic AMP...
Abstract Stem cell-based organ regeneration is purported to enable the replacement of impaired organs in foreseeable future. Here, we demonstrated that a combination cultured epidermal stem cells (Epi-SCs) derived from epidermis and skin-derived precursors (SKPs) was capable reconstituting functional hair follicles sebaceous glands (SG). When Epi-SCs SKPs were mixed hydrogel implanted into an excisional wound nude mice, formed de novo along with follicles, contributed dermal papilla neogenic...
Abstract Nectin-3, a cell adhesion molecule enriched in hippocampal neurons, has been implicated stress-related cognitive disorders. Nectin-3 is expressed by granule cells the dentate gyrus (DG), but it remains unclear whether nectin-3 DG modulates structural plasticity of and hippocampus-dependent memory. In this study, we found that expression levels were developmentally regulated reduced early postnatal stress exposure adult mice. Most importantly, knockdown all neuron populations...
Surgical site infection (SSI) after colorectal surgery (CRS) remains a significant problem for its negative clinical outcomes. However, it is poorly understood in China. This study aims to investigate the incidence, risk factors and microbiology of SSI CRS.A nationwide prospective multicenter design was applied. Patients 19 Chinese hospitals from 2015 2018 were prospectively monitored CRS. Demographic data, hospital characteristics, potential perioperative collected analyzed, using...
Abstract Background For patients with multilevel degenerative cervical myelopathy, laminectomy and posterior fusions (PCF) instrumentation are widely accepted techniques for symptom relief. However, hardware failure is not rare results in neck pain or even permanent neurological lesions. There no in-depth studies of hardware-related complications following PCF instrumentation. Methods The present study was a retrospective, single centre, observational study. Patients who underwent...
Abstract Background To find out if three-dimensional printing (3DP) off-the-shelf (OTS) prosthesis is superior to titanium mesh cages in anterior cervical corpectomy and fusion (ACCF) when treating single-segment degenerative spondylotic myelopathy (DCSM). Methods DCSM patients underwent ACCF from January 2016 2019 a single center were included. Patients divided into the 3DP group (28) TMC (23). The hospital stays, operation time, intraoperative blood loss, cost of hospitalization compared....
Abstract Despite previous studies, the association between screen-based sedentary behavior (SB) and erectile dysfunction (ED) remains unclear. This study aimed to investigate relationship SB ED using data from 2001–2004 National Health Nutrition Examination Survey (NHANES). A total of 4,047 participants were included, whom 1,192 (29.5%) had ED. Multivariable logistic regression models used analyze this association. After adjusting for potential confounders, exceeding 2 h per day was...
To elucidate whether miRNA-27a-3p can promote osteogenic differentiation of hMSCs by targeting ATF3, thus alleviating osteoporosis symptoms.The serum levels in patients (n=20) and normal controls were detected quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Human bone marrow mesenchymal stem cells (hMSCs) subjected to for 1, 3 7 days. Subsequently, mRNA miRNA-27a-3p, ALP, Bglap determined qRT-PCR. The regulatory effects the Bglap, Runx2 detected. After overexpression or knockdown...
Aspect Based Sentiment Analysis (ABSA) provides fine-grained sentiment information compared with traditional analysis. There are two approaches to the task, aspect term analysis (ATSA) and category (ACSA). In this paper, we propose a model, namely Recurrent Neural Network Target Embedding (RTE) using target enhance technic improve accuracy of both kinds approaches. Specifically, RTE involves stacked LSTMs for extraction analysis, unit spreading or information. Experiments conducted on...
Long non-coding RNA (lncRNA), is essential for the development and progression of cancers. LncRNA regulates target gene expression by sponging corresponding microRNA (miRNA) during tumorigenesis. This work aimed to explore role one lncRNA, ELFN1-AS1, in colorectal cancer (CRC) elucidate pertinent signaling pathway.First, we found that ELFN1-AS1 was highly abundant human CRC tissues cell lines. Silence reduced proliferation, colony formation, migration invasion, while inducing apoptosis...
Background The monocyte-macrophage-dendritic cell (DC) (MMD) system exerts crucial functions that may modulate fibrogenesis in nonalcoholic steatohepatitis (NASH). In this study, we explored the characteristics, distribution and developmental trajectory of liver MMD NASH mice with fibrosis clarified characteristic genes involved progression patients. Methods Single cells tissue samples from normal were quantified using single-cell RNA sequencing (scRNA-seq) analysis. Differentially expressed...
Non-alcoholic fatty liver disease (NAFLD) is a global commonly occurring disease. However, its exact pathogenesis not fully understood. The purpose of this study was to quantitatively evaluate the progression steatosis and fibrosis by examining their distribution, morphology, co-localization in NAFLD animal models. Six mouse groups were established: (1) western diet (WD) group; (2) WD with fructose drinking water (WDF) (3) WDF + carbon tetrachloride (CCl4) group, plus intraperitoneal...
This study characterized CXC chemokine receptor 4 (CXCR4) expression in patients with mitral valve disease and chronic atrial fibrillation (AF). Forty-eight AF formed two groups based on whether they were treated or without renin–angiotensin system (RAS) blockers (AF + RAS group; n = 25, – 23). The controls comprised 17 sinus rhythm (SR group). CXCR4 mRNA protein levels the left atria significantly higher than SR group. was lower group More CD34 cells expressed Angiotensin II, collagen I...
In the current study, effect of glucosamine methyl ester on cartilage degeneration in osteoarthritis rat model was investigated.Forty Sprague-Dawley rats were assigned into 5 groups 8 animals each. Osteoarthritis induced 4 using medial parapatellar incision followed by anterior cruciate ligament transection and meniscectomy. Normal given normal saline. The three treatment received 2, 10 mg/kg doses daily for one month.Microscopic examination knee showed a significant reduction score groups....
Aberrant activation of (Wingless and mouse homolog Int-1) Wnt/β-catenin signaling pathways closely involved in the occurrence progression several types human malignancies. This research was undertaken to elucidate important role lung cancer.Wnt3 expression cancers their respective normal tissues were examined by immunoblotting immunohistochemistry. Then, Wnt3 regulated with RNA interference (RNAi) technology cancer A549 cells, cell proliferation, cycle, invasion/metastasis, apoptosis...
To investigate how different quality of day 3 (D3) embryos affect blastocyst formation and clinical outcomes. This retrospective study analysed 699 patients undergoing assisted reproductive technology (ART) between January 2017 February 2021. A total 2517 D3 were transferred to medium for extended culture. divided into five groups. Grade A, 6-10 cells, symmetrical blastomeres <20% fragmentation; grade B, uneven ≥20% C, >10 D, E, <6 cells. Status 5 (D5) 6 (D6) blastocysts the outcomes...