A5108060688- Breast Cancer Treatment Studies
- Head and Neck Surgical Oncology
- Breast Lesions and Carcinomas
- Ear and Head Tumors
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Sinusitis and nasal conditions
- Oral and Maxillofacial Pathology
- Cancer Treatment and Pharmacology
- Breast Implant and Reconstruction
- Amyotrophic Lateral Sclerosis Research
- Advanced Breast Cancer Therapies
- Nausea and vomiting management
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Neurogenetic and Muscular Disorders Research
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Genetics and Neurodevelopmental Disorders
- Medical Imaging Techniques and Applications
- Neurological diseases and metabolism
- Advanced Radiotherapy Techniques
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2021
Peking Union Medical College Hospital
2009-2020
Hebei Medical University
2013
Purpose This study aims to investigate the prognostic value of composition and spatial architecture tumor-infiltrating lymphocytes (TILs) as well PDL1 expression on TILs subpopulations in nasopharyngeal carcinoma (NPC). Methods A total 121 patients with NPC were included divided into two groups: favorable (n = 68) unfavorable 53). The archived tumor tissues retrieved, a tissue microarray was constructed. density distribution infiltration analyzed using multiplex fluorescent...
Abstract Background The aim of this study is to evaluate the efficacy different treatment strategies and potential prognostic factors esthesioneuroblastoma (ENB). Materials methods Between April 1984 December 2018, 138 patients with non-metastatic ENB were retrospectively analyzed. modalities mainly included surgery alone ( n = 7), radiotherapy 33), concurrent chemoradiotherapy 17), combined current 32), plus 49). Results median follow-up time for entire cohort was 61 months (range, 4–231...
To develop a nomogram for predicting the possibility of four or more positive nodes in breast cancer patients with 1-3 sentinel lymph (SLN).Retrospective analysis data from two institutions was conducted. The inclusion criteria were: invasive cancer; clinically node negative; received lumpectomy mastectomy plus SLN biopsy followed by axillary dissection (ALND); and pathologically confirmed T1-2 tumor, SLNs. Patients one institution formed training group other validation group. Univariate...
To analyze the incidence and spread of lymph node metastasis (LNM) effectiveness prophylactic neck irradiation in patients with SNSCC.A total 255 SNSCC were retrospectively reviewed. The LNM pattern was revealed. clinical parameters related to LNM, prognostic value elective (ENI) assessed. A 1:1 matching propensity scores performed between ENI group observation (OBS) group.The initial rate 20.8%, regional recurrence (RR) 7.5%. Lymphatic spreading followed common trajectories: a. level Ib ➔...
Objective To investigate whether the polymorphism of rs10260404 in DPP6 gene Chinese Han origin is associated with sporadic amyotrophic lateral sclerosis (SALS). Methods The genomic DNA was extracted from leukocytes whole blood samples 58 patients SALS and 52 healthy controls. asymmetric PCR processed presence an unlabeled probe that contained locus. product genotyped on light scanner some confirmed sequencing. Results Two single nucleotide polymorphism, reportedly consistently strongly...
Abstract Background To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with without post-mastectomy radiotherapy: 4604 (65.1%) had pT1–2 N0 disease (low risk); 2042 (28.9%), N1 (intermediate and 427 (6.0%), pT3–4 and/or pN2–3, or neoadjuvant chemotherapy (high risk). distribution cumulative was analyzed. local regional rates were estimated by Kaplan-Meier method, differences compared log-rank...
To investigate the effect of chemotherapy and radiotherapy timing after breast conserving surgery (BCS) on recurrence survival women with early-stage cancer. We retrospectively analyzed 900 patients who underwent BCS followed by both adjuvant radiotherapy. Of these, 488 received first (CT-first group) while other 412 (RT-first group). Locoregional (LRR), distant metastasis (DM), disease-free (DFS), overall (OS) rates were calculated using Kaplan-Meier method further confirmed...
Abstract Background To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), to investigate role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer. Methods A total 4262 women T1–2N1M0 cancer treated at two institutions were retrospectively reviewed. 3858 underwent MRM, 832 (21.6%) them received postoperative RT (MRM + RT). 404 BCS plus (BCS All axillary lymph node dissection, while 3.8% had upfront sentinel biopsy. The...
To determine oncologic outcomes for patients with T4b sinonasal squamous cell carcinoma (SNSCC) treated either surgery plus radiotherapy or definitive radiotherapy.Between January 1999 and December 2016, 85 SNSCC were analyzed retrospectively, there 54 who received (S + RT group) ± chemotherapy 31 (RT chemotherapy. A 1: 2 propensity score matching (PSM) was performed to balance clinical factors match patients. Kaplan-Meier method Cox proportional hazard model used risk on survival...
Abstract Background Robotic linac is ideally suited to deliver hypo-fractionated radiotherapy due its compact head and flexible positioning. The non-coplanar treatment space improves the delivery versatility but complexity also leads prolonged optimization time. Methods In this study, we attempted use deep learning (pytorch) framework for plan of circular cone based robotic radiotherapy. problem was topologized into a simple feedforward neural network, thus transformed network training. With...
Objective: To investigate the overall efficacy of early breast cancer after breast-conserving treatment. analyze risk factors affecting local regional recurrence (LRR), distant metastasis (DM) and survival. Methods: 1 791 patients treated with surgery were retrospectively analyzed. The inclusion criteria pathologic diagnosis invasive without supraclavicular internal mammary node metastasis, T1-2N0-3M0, no neoadjuvant therapy. Univariate analysis survival was performed by Kaplan-Meier method...
The necessity of level III irradiation in patients with node-negative advanced sinonasal squamous cell carcinoma (SNSCC) is unclear.Seventy-eight SNSCC were included. Survival rates estimated and compared between treatment groups.Twenty-five received ipsilateral levels Ib II (group 1) 53 plus 2). median follow-up time was 75.56 months. Five-year survival (regional relapse-free survival, overall local distant metastasis-free survival) similar groups 1 2 (all p > 0.05). Irradiation doses to...
The use of radiotherapy to treat early stage breast cancer following breast-conserving surgery has markedly increased. study aimed evaluate the clinical practice in China.A survey concerning characteristics for was distributed all departments mainland China 2009. results were analyzed.Three hundred and ninety-six replied (41.6%), 328 (34.4%) launched radiotherapy. Adjuvant chemotherapy followed by most common combination performed 55.2% responding centers. median time from 9 weeks. Three...
To analyze the failure patterns in patients with different histological subtypes of sinonasal malignancies (SNMs).Retrospectively gathered data.Academic university hospital.Patients SNMs treated at a tertiary referral center between January 1999 and 2019 were included. We assessed within subtypes.The study included 897 patients. The median follow-up time was 100 months. Adenoid cystic carcinoma (ACC) had moderate risk developing local recurrence (LR) distant metastasis (DM). Compared ACC,...
Abstract Background Neuroendocrine neoplasm is a rare cancer of head and neck. This study aimed to evaluate clinical features, treatment outcomes, prognostic factors neuroendocrine neck treated at single institution. Methods Between Nov 2000 2021, ninety-three patients diagnosed with neoplasms our institution were reviewed retrospectively. The initial treatments included chemotherapy (induction, adjuvant, or concurrent) combined radiotherapy in 40 (C + RT group), surgery followed by...
Objectives Primary frontal sinus malignancies (FSMs) are the rarest sinonasal cancers. This study aimed to determine clinicopathologic characteristics of primary FSMs and provide long-term survival outcomes. Design is a retrospective review. Setting The was conducted at tertiary medical center. Participants Patients who participated in this were diagnosed with FSMs. Main Outcome Measures Median time outcome measure study. Results In series, median age 48 years (30-53 years) all patients...
Abstract Background : To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with without post-mastectomy radiotherapy: 4604 (65.1%) had pT1-2N0 disease (low risk); 2042 (28.9%), pT1-2N1 (intermediate and 427 (6.0%), pT3-4 and/or pN2-3, or neoadjuvant chemotherapy (high risk). distribution cumulative was analyzed. local regional rates were estimated by Kaplan-Meier method, differences compared...
This study aimed to evaluate the prognostic value of pretreatment systemic immune-inflammation index (SII) in non-metastatic nasopharyngeal carcinoma (NPC). We retrospectively analyzed data 839 patients with NPC recruited from two independent institutions. The training-set cohort and external validation-set was comprised 459 380 each institution, respectively. optimal cut-off SII determined, a risk stratification model developed based on training further assessed validation cohort....
Objective To evaluate the risk factors of non-sentinel lymph node (NSLN) metastasis in breast cancer patients with 1-2 positive sentinel nodes and to establish a new Nomogram prediction model. Methods Clinicopathological data who were diagnosed 1–2 underwent axillary dissection (ALND) without neoadjuvant chemotherapy from January 2008 December 2014 retrospectively analyzed. Measurement between two groups analyzed by chi-square test. Multivariate analysis was performed logistic...
Abstract Objective Our objective was to compare the long-term outcomes of endoscopic resection versus open surgery in combination with radiotherapy for locally advanced sinonasal malignancies (SNMs). Methods Data continuous patients squamous cell carcinoma and adenocarcinoma who received (endoscopic or surgery) combined our center between January 1999 December 2016 were retrospectively reviewed. A 1:1 matching propensity scores performed. Overall survival (OS), progression-free (PFS), local...
Purpose The aim of this study is to evaluate the role regional nodal irradiation (RNI) in patients with T1-2N1M0 breast cancer and identify subgroup that could benefit from RNI. Methods materials A total 4,243 women pT1-2N1M0 treated at two institutions China were retrospectively reviewed. Survival rates calculated by Kaplan–Meier method compared log-rank test. association risk factors survival outcomes was evaluated using multivariable proportional hazards regression. Results 932 (22.0%)...