A5000818604- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Insect and Pesticide Research
- Advanced Polymer Synthesis and Characterization
- Seaweed-derived Bioactive Compounds
- Extracellular vesicles in disease
- Malaria Research and Control
- Phytochemistry and Biological Activities
- Cancer-related Molecular Pathways
- Polymer Surface Interaction Studies
- Polysaccharides and Plant Cell Walls
- Natural product bioactivities and synthesis
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Tuberculosis Research and Epidemiology
- Pomegranate: compositions and health benefits
- Plant-Derived Bioactive Compounds
- Bioinformatics and Genomic Networks
- Bioactive Compounds and Antitumor Agents
- Cancer-related molecular mechanisms research
- Diverse Scientific Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
Sunway University
2024-2025
Monash University Malaysia
2024
Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in substantia nigra pars compacta. The precise etiology PD remains unclear, but emerging evidence suggests significant role for disrupted autophagy-a crucial cellular process maintaining protein and organelle integrity.
Abstract Seaweeds have been utilized as food, fodder, fertilizer, and medicine since ancient times; nevertheless, they received only a little attention. In the current work, we extracted sulfated polysaccharide from marine source investigated its anti-arthritic potential in vivo . The isolated freeze-dried was tested for acute oral toxicity based on OECD 423. This step followed by investigations clinical signs gross pathological alterations seen. A complete Freund’s adjuvant-induced...
In recent years, the development of biomaterials from green organic sources with nontoxicity and hyposensitivity has been explored for a wide array biotherapeutic applications. Polyphenolic compounds have unique structural features, self-assembly by oxidative coupling allows molecular species to rearrange into complex biomaterial that can be used multiple Self-assembled polyphenolic structures, such as hollow spheres, designed respond various chemical physical stimuli release therapeutic...
Aim: The objective of this study was to develop and characterize the physical properties fast-melting tablets (FMTs) using cocoa butter as base caffeine model drug. Method: simple refrigerator freezing method employed prepare caffeine-loaded, FMTs from bases. Results: F3 chosen formulation achieved a disintegration time 1.20 min ± 0.035, which falls within specified limit set by European Pharmacopoeia. cumulative drug release data F3, 88.52 94.08% 60 75 min, respectively (NLT 85% per US FDA...
Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition (DHC), which encompasses a complex range cardiovascular issues linked to diabetes associated cardiomyopathies. Despite significant progress reducing mortality rates from diseases (CVDs), failure remains major cause increased morbidity among patients. These cellular processes are essential for maintaining balance removing damaged or dysfunctional components, their involvement...
Abstract Background Rheumatoid arthritis (RA) is a debilitating inflammatory disorder characterized by an overactive immune system targeting joints, leading to inflammation and intense pain. While current RA therapies effectively alleviate symptoms, they are often associated with significant side effects. This study aimed assess the anti-inflammatory anti-arthritic properties of Ethanolic Extract Myxopyrum serratulum A.W. Hill (EEMS) using animal models. Results The acute toxicity EEMS (2000...