This paper reports the antifungal properties of zinc oxide nanoparticles (ZnO NPs) on Candida albicans ATCC 1023 through study growth inhibitory effects ZnO NPs C. and effect surface albicans. The (5, 10, 20, 40, 80, 160 µg/mL) at 24 h were determined reduction in suspension turbidity colony count. Fourier transform infrared (FTIR) analysis was carried out to establish functional groups associated with interaction yeast cell wall, while scanning electron microscopy (SEM) energy dispersive...

Microneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic diseases like diabetes look for alternative pain-free treatment regimens circumventing subcutaneous injections. Insulin microneedles (INS-MNs) a thoughtfully researched topic (1) overcome phobia in patients, (2) controlled the peptide, (3) decreasing frequency drug administration, (4) ease...

The present study is the pioneer that aimed to prepare zinc oxide nanoparticles (ZnO-NPs) with colchicine as reducing and capping agent. Colchicine-loaded ZnO-NPs (CHZnO-NPs) were prepared by adding sulfate heptahydrate solution. formulation was then characterized determine morphology, size, crystallinity, elemental composition vibrational properties of CHZnO-NPs. Upon characterization, CHZnO-NPs studied for their cytotoxic effect against breast cancer cell line (MDA-MB-231). successful...

Transferosomes are one of the vesicular carriers that have received extensive research and attention recently because their capacity to get beyond barriers posed by stratum corneum penetration. The intent current study is optimize evaluate proanthocyanidin (PAC) containing transferosomal transdermal gels. PAC-containing transferosomes were prepared using film hydration method then loaded into a 4% methylcellulose gel. A 23 Box-Behnken design was used PAC-loaded gel, where effects...

Alzheimer's disease (AD) is a major cause of disability and one the top causes mortality globally. AD remains public health challenge due to its prevalence, impact on patients caregivers, current lack cure. In recent years, polyphenols have garnered attention for their potential therapeutic effects AD. The objective study was establish network pharmacology between selected plant origin Insilico tools such as SwissADME, ProTox3.0, pkCSM, Swiss Target Prediction, DisGeNET, InterActiVenn, DAVID...

Background: Hyperlipidemia, characterized by a persistent elevation of lipid levels in the bloodstream, serves as major indicator cardiovascular risk. Although statin drugs are effective managing this condition, their use is often accompanied with adverse side effects and drug reactions. Aim Objective: In light these limitations, exploration herbal natural remedies for treatment hyperlipidemia has gained momentum. This study investigates antihyperlipidemic potential Rivea hypocrateriformis...

Background: Cocoa Butter (CB) is rich in triglycerides and various types of fatty acids, which provides it with occlusive effect on the skin. However, not commonly used as a main ingredient modern formulated topical moisturizing creams. Consequently, this study was to examine impact CB primary skin cream. Aim: To occlusivity principal component moisturizer Methods: prepare cream, oil phase, containing polyethene glycol (PEG) 200, beeswax, CB, heated molten state before being combined aqueous...

Abstract: Over the past two decades, supercritical fluid technology has emerged as one of most important technologies applied in many fields such cosmetic, food and pharmaceutical. Supercritical extraction process offers numerous advantages easy, effective, inexpensive, high quality solute environmentally friendly. This mini-review describes fundamentals technology, function solvent anti-solvent, mechanism fluid, disadvantages revisit application pharmaceutical sciences. In-depth discussion...

Zinc oxide nanoparticles (ZnO NPs) are widely used in biomedical applications due to their antimicrobial and antioxidant properties. The objective of the present study was determine antifungal activity ZnO NPs against yeast Saccharomyces cerevisiae. turbidity test results showed a significant (p < 0.05) dose-dependent growth inhibitory effect on S. cerevisiae as inhibition increased from 7.04 ± 0.64 70.30 3.19% concentration 5 150 μg/mL. scanning microscopy images evidenced morphological...

The major goal of this investigation was to prepare carvedilol nanocrystals (CRL-NCs) for better solubility, stability, and bioavailability. Using polyvinyl pyrolidine K-30 (PVP) sodium dodecyl sulphate (SDS) as stabilisers, CRL-NCs were effectively synthesised by emulsion-diffusion, followed the high-pressure homogenization (HPH) method. AL classes phase solubility curves with ideal complexes produced stabilisers estimated thermodynamic parameters. docking study performed active site a β-1...

Abstract The intention of this study was to prepare zinc oxide nanoparticles (ZnO‐NPs) via bottom‐up approach and evaluate their physiochemical, antimicrobial anticancer properties. ZnO‐NPs were first prepared by the direct precipitation method with sulphate heptahydrate, followed characterization tests using sophisticated analytical imaging instruments. Upon characterization, studied for activities against Staphylococcus aureus, epidermidis Pseudomonas aeruginosa as well activity breast...

Aim: The objective of this study was to develop and characterize the physical properties fast-melting tablets (FMTs) using cocoa butter as base caffeine model drug. Method: simple refrigerator freezing method employed prepare caffeine-loaded, FMTs from bases. Results: F3 chosen formulation achieved a disintegration time 1.20 min ± 0.035, which falls within specified limit set by European Pharmacopoeia. cumulative drug release data F3, 88.52 94.08% 60 75 min, respectively (NLT 85% per US FDA...

Introduction: To identify the various phyto constituents present in unexplored plant Rostellularia diffusa (Willd.) by using gas chromatography and mass spectrometry. Methods: The whole of was extracted with ethyl acetate at room temperature for 72 h. concentrated extract subjected to GCMS analysis detect constituents. Results: Totally 40 compounds were identified chromatograph showed peaks individual compounds. major 16-Hentriacontanone (22.59%), Hexadecanoic acid (11.23%),...

Plants are the natural source for antioxidants from plants is boon investigators. Present study was aimed to antioxidant activity and phytochemical screening of Cananga odorata (Lam.) Hook. f. & Thomson extract. Study involved preparation hydroalcoholic extract leaves (HECOL) using maceration method, followed by its activity. The HECOL subjected determination total phenolic content (TPC) flavonoid (TFC), DPPH (1,1-Diphenyl-2-picryl hydrazyl) radical scavenging assay Maceration C. solvent...

Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods Material: Bark leaf part were extracted with water methanol. Swiss rats used to evaluate vivo effects streptozotocin induced body weight loss, oxidative stress, hyperglycemia hyperlipidemia. Statistical analysis : Data analysed by One - way ANOVA, followed Turkey –Kramer Multiple Comparison Test. Results: extract treated animals demonstrated...

Abstract Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it plagued by low water solubility, permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose of the present study was to develop self-microemulsifying drug delivery system (SMEDDS) enhance oral bioavailability vorinostat. Capryol 90, labrasol, polyethylene glycol (PEG 400) were selected as oil phase, surfactant, co-surfactant,...

Zinc oxide nanoparticles (ZnO-NPs) were synthesized using ginger (Zingiber officinale) extracts in a green synthesis approach and evaluated their vitro cytotoxicity effect on the MDA-MB 231 breast cancer cell line. The bottom-up was employed to develop green-synthesized ginger-encapsulated ZnO-NPs (GZnO-NPs) without hazardous substances. most substantial Fourier-transform infrared absorption peak of root extract seen at 1634.24 cm-1. also confirmed presence extract-encapsulated 1556.79,...

Formulation and comparison of in vitro release profile hydrophilic hydrophobic polymer based Naproxen matrix tabletsKumar Bishwajit Sutradhar, Tajnin Ahmed, Afia Ferdous, Riaz Uddin