A5012554156- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Bee Products Chemical Analysis
- Phagocytosis and Immune Regulation
- Healthcare and Venom Research
- Adipokines, Inflammation, and Metabolic Diseases
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Immune cells in cancer
- Biomarkers in Disease Mechanisms
- Multiple Myeloma Research and Treatments
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Curcumin's Biomedical Applications
- Retinal Development and Disorders
- Synthesis and biological activity
- Silk-based biomaterials and applications
- Reproductive tract infections research
- Vitamin C and Antioxidants Research
Maastricht University
2018-2025
Maastricht University Medical Centre
2020-2025
RWTH Aachen University
2020-2025
Cardiovascular Institute Hospital
2024-2025
Ludwig-Maximilians-Universität München
2019-2025
Institute for Sports Medicine
2019-2024
Universitätsklinikum Aachen
2021-2023
Prevention Institute
2020
German Centre for Cardiovascular Research
2020
Ruhr University Bochum
2006
Abstract CCL17 is produced by conventional dendritic cells, signals through CCR4 on regulatory T (T reg ) cells and drives atherosclerosis suppressing functions yet undefined mechanisms. Here we show that from CCL17-deficient mice display a pro-tolerogenic phenotype transcriptome not phenocopied in lacking its cognate receptor CCR4. In the plasma of mice, CCL3 was only decreased cytokine/chemokine. We found signaled CCR8 as an alternate high-affinity receptor, which induced expression...
Abstract Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a residual risk; therefore, novel therapeutic candidates targeting inflammation are needed. The endothelium starting point vascular underlying atherosclerosis we could previously demonstrate that chemokine axis CXCL12–CXCR4 plays an important role disease...
Non-healing wounds are usually colonised and contaminated by different types of bacteria. An alternative to antibiotic treatment in patients with infected local signs inflammation may be medical grade honey (MGH). MGH has antioxidant, antimicrobial, anti-inflammatory, immunomodulatory features. This study aims evaluate the effect therapy on non-healing wounds, especially for diabetic foot syndrome. Prospective, observational case series (n = 5) syndrome presented. There were five males an...
Objective- Expression of the chemokine-like receptor ChemR23 (chemerin 23) has been specifically attributed to plasmacytoid dendritic cells (pDCs) and macrophages suggested mediate an inflammatory immune response in these cells. Because chemokine receptors are important perpetuating chronic inflammation, we aimed establish role ChemR23-deficiency on pDCs atherosclerosis. Approach Results- ChemR23-knockout/knockin mice expressing eGFP (enhanced green fluorescent protein) were generated after...
Background Traumatic skin injuries (TSI) are more common to geriatric population due reduced elasticity and increased gait instability. This is also associated with an altered wound-healing mechanism thus requires a cost-efficient effective treatment. Therefore, the aim of present study highlight efficacy medical-grade honey (MGH) supplemented vitamins C E for conservative treatment TSI in home-care setting. Methodology The multicenter retrospective case series included 10 patients (four men...
The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b (miR-26b) might play a role in several MASH-related pathways. Therefore, we aimed to determine miR-26b MASH and its therapeutic potential using mimic-loaded lipid nanoparticles (LNPs). Apoe -/- Mir26b , LysM cre fl/fl mice, respective controls were fed western-type diet induce MASH. Plasma liver samples characterized regarding metabolism,...
The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b ( Mir26b ) might play a role in several MASH-related pathways. Therefore, we aimed to determine MASH and its therapeutic potential using mimic-loaded lipid nanoparticles (LNPs). Apoe -/- , Lyz2 cre fl/fl mice, respective controls were fed Western-type diet induce MASH. Plasma liver samples characterized regarding metabolism, hepatic...
Venous leg ulcers (VLUs) are hard-to-heal wounds and prone to microbial colonization. Innovative improved therapies thus required resolve local infection enhance the wound healing process. The objective of this study was evaluate effectiveness medical-grade honey (MGH) for treatment clinically infected non-healing VLUs. This prospective case series included nine patients with an average age 83.4 years (range: 75-91 years) a total eleven VLUs, previously ineffectively treated various...
The transmembrane protease A Disintegrin And Metalloproteinase 10 (ADAM10) displays a "pattern regulatory function," by cleaving range of membrane-bound proteins. In endothelium, it regulates barrier function, leukocyte recruitment and angiogenesis. Previously, we showed that ADAM10 is expressed in human atherosclerotic plaques associated with neovascularization. this study, aimed to determine the causal relevance endothelial murine atherosclerosis development vivo.Endothelial Adam10...
The prevalence of bacterial vaginosis (BV) among women reproductive age is 29%. BV arises from a vaginal imbalance marked by reduced levels lactic acid-producing lactobacilli and an overgrowth pathogenic anaerobes. multifactorial nature BV's pathogenesis complicates its treatment. Current antibiotic therapy exhibits recurrence rate about 60% within year. Recurrence can be caused treatment failure (e.g., due to antimicrobial resistance), the persistence residual infections biofilm formation),...
Sunitinib is a multitarget tyrosine kinase inhibitor (TKI) used for cancer treatment. In platelets, sunitinib affects collagen-induced activation under noncoagulating conditions. We investigated (1) the effects of on thrombus formation induced by other TK-dependent receptors, and (2) coagulating Cardiovascular disease comorbidity in patients, resulting possible aspirin are associated with increased bleeding risk, therefore we also (3) synergistic these compounds fibrin formation. Blood or...
Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in wounds. Silver-based dressings commonly used treatment burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated antimicrobial effects possible cytotoxicity L-Mesitran Soft (MGH-gel) its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), silver nitrate...
Abstract Background MicroRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that involved in post-transcriptional regulation of gene expression multicellular organisms by affecting both the stability and translation mRNAs. One miRNAs has been shown to play a role various pathologies like cancer, neurological disorders cardiovascular diseases is miRNA-26b. However, these studies only demonstrated rather ambiguous associations without revealing causal relationship. Therefore, aim this study...
Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation. Atypical chemokine receptor 3 (ACKR3) expression was shown increase in AT during obesity, its ubiquitous elimination caused hyperlipidemia mice. Although these findings point towards a role ACKR3 regulation levels, adipocyte-specific has not yet been studied exclusively this context. In study, we established adipocyte-...
Platelets are key regulators of haemostasis, making platelet dysfunction a major driver thrombosis. Numerous processes that determine function influenced by microRNAs (miRs). MiR-26b is one the highest-expressed miRs in healthy platelets, and its expression platelets changed diseased state. However, exact effect this miR on has not been studied yet. In study, we made use whole-body knockout miR-26b ApoE-deficient mice order to impact function, thrombus formation signalling both ex vivo vivo....
Abstract The calcium sensing receptor (CaSR) is a G-protein coupled that especially plays an important role in the of extracellular to maintain its homeostasis. Several in-vitro studies demonstrated CaSR adipose tissue metabolism and inflammation, resulting systemic inflammation contributing atherosclerosis development. aim this study was investigate whether adipocyte in-vivo By using newly established conditional mature specific deficient mouse on hyperlipidemic prone Apoe −/− background it...
Diabetic retinopathy (DR) is one of the major complications diabetes, which eventually leads to blindness. Up date, no animal model has yet shown all co-morbidities often observed in DR patients. Here, we investigated whether obese 42 weeks old ZSF1 rat, spontaneously develops hypertension and obesity, would be a suitable study DR. Although arteriolar tortuosity increased retinas from as compared lean (hypertensive only) rats, vascular density pericyte coverage, microglia number, morphology...
Proprotein convertase subtilin/kexin type 9 (PCSK9) is a protease secreted mainly by hepatocytes and in lesser quantities intestines, pancreas, vascular cells. Over the years, this has gained importance field of cardiovascular biology due to its regulatory action on low-density lipoprotein receptor (LDLR). However, recently, it also been shown that PCSK9 acts independent LDLR cause inflammation increase severity several disorders. We hypothesized affects expression chemokine receptors, major...